Features | Partner Sites | Information | LinkXpress
Sign In
Demo Company

Bruker and 3M Collaborate for MALDI Imaging for Cancer Research

By BiotechDaily International staff writers
Posted on 14 Jun 2013
Bruker Corp. (Billerica, MA, USA) reported that it has signed an exclusive patent license agreement with 3M Company (Maplewood, MN, USA), which allows Bruker to include 3M patented technology related to matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging.

The licensed 3M patents are directed to a technique for performing mass spectrometry analysis on proteins in tissue that has been preserved in paraffin. The technology enables researchers to study formalin-fixed, paraffin-embedded (FFPE) tissue for drug development and life-science research.

MALDI imaging has been increasingly utilized to analyze clinically pertinent tissues such as tumor biopsies. The molecular phenotypes visualized by MALDI imaging have been demonstrated to correlate with parameters such as disease status or patient outcome, and have been effectively applied to the categorization of tissue samples.

MALDI imaging was first developed for the analysis of fresh, frozen tissue sections, however, the analysis of preserved FFPE tissue sections is becoming increasingly important due to methodological enhancements. In the MALDI imaging community, it is widely accepted that a meaningful analysis of FFPE tissue requires a pretreatment called antigen-retrieval.
Dr. Sören-Oliver Deininger, market manager for MALDI imaging at Bruker, stated, “The interest in the analysis of FFPE tissue by MALDI imaging is increasing strongly. Bruker has developed innovative technology to make MALDI imaging viable in histopathology by the integration of virtual microscopy and the possibility to classify tissue based on the molecular phenotypes [class-imaging]. Our license agreement with 3M shows our ongoing commitment to the MALDI imaging field, and gives our customers the necessary freedom to conduct their research and advance the field.”

MALDI imaging is suited to analyze biomarkers in tissue samples. By enabling histologic correlation of molecular phenotypes and correlation of molecular signals to clinical endpoints, the technology is an effective application for cancer research. It directly images metabolites, peptides, proteins, lipids, and drugs in FFPE samples with no antibodies, probes, fluorescent dyes, or radiolabels needed.

However, analysis can be complex, tiresome, and difficult to interpret. Bruker has developed special software that supports the entire workflow, including statistical analysis, providing simple and automated interpretation and reporting of results. This new agreement with 3M supports the continued development and use of this important enabling application.

Related Links:

3M Company



view channel
Image: Micrograph showing immunofluorescence of skin differentiation markers for basal keratinocytes (Photo courtesy of Dr. Russ Carstens, University of Pennsylvania).

Alternate Splicing Proteins Critically Linked to Skin and Organ Development

Two proteins that regulate alternative splicing in epithelial cells have been linked to the proper development of the skin and protective layers that surround other organs in the body. Two steps are... Read more

Drug Discovery

view channel
Image: Endoscopic image of a bowel section known as the sigmoid colon afflicted with ulcerative colitis. The internal surface of the colon is blotchy and broken in places (Photo courtesy of Wikimedia Commons).

Orally Delivered Curcumin-Loaded Microparticles Effectively Treat Mouse Model of Ulcerative Colitis

Microparticles (MPs) loaded with the efficient anti-inflammatory agent curcumin were found to effectively treat a mouse model of ulcerative colitis. Ulcerative colitis is a chronic relapsing disease... Read more

Lab Technologies

view channel

New Genomic Research Kit Simplifies Exome Studies

An exciting new tool is now available for biotech researchers working in the field of genomic analysis. The human exome is critical to our genetic make-up and is generally accepted as having the greatest influence on how the genetic blueprint is utilized. The exome is defined as all coding exons in the genome and is... Read more


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.