Features | Partner Sites | Information | LinkXpress
Sign In
Demo Company

Ingenuity Systems Acquired by Qiagen, Adding Analysis, Interpretation of Complex Biologic Data Technology

By BiotechDaily International staff writers
Posted on 07 May 2013
Qiagen NV (Hilden, Germany) has acquired Ingenuity Systems, Inc. (Redwood City, CA, USA), a leading provider of biomedical software that effectively analyzes and interprets the biologic meaning of genomic data. Ingenuity has created a curated knowledge system of biomedical data and analysis solutions for the investigation, interpretation, and analysis of complex biologic systems.

New developments such as next-generation sequencing (NGS) are now generating more data in only one year than was generated in all prior history, making the analysis and interpretation of this wide-ranging and very complex biologic data a critical success factor.

At the core of Ingenuity’s product range is the Ingenuity Knowledge Base, a 14-year endeavor to effectively and manually curate, model, and computationally structure the immense amount of biomedical literature, including genomic variations associated with human disease and thousands of disease models. The Ingenuity Knowledge Base and software applications enable users to accurately interpret the significance of increasingly large amounts of biologic data to better direct research and medical treatment decisions.

Ingenuity’s Knowledge Base is constructed on algorithms that pair all human gene variants with biologic interpretations based on known outcomes and discoveries. These pairings are gathered and reviewed by specialists (curated) in a standardized way from a wide range of sources including clinical and scientific publications with the support of advanced technology and refined processes. This process and the associated learning algorithms translate sourced data into interoperable and linkable collections of relevant information.

The Ingenuity product range includes the Ingenuity pathways analysis (IPA) standard web-based software application, which enables researchers to model, analyze, and determine the complex biologic systems at the core of life sciences research. IPA is deployed in most major pharmaceutical companies and hundreds of biotechnology companies and academic institutions globally. It supports data analysis and interpretation from all high-throughput analysis platforms and it is used in virtually all areas of drug discovery and development from target identification and validation to predictive toxicology, biomarkers, and pharmacogenomics.

Ingenuity variant analysis is a web-based NGS data analysis application that solves a vital requirement for researchers trying to rapidly identify relevant causal variants in human diseases in a matter of hours. It enables customers to rapidly identify and prioritize variants by drilling down to a small, targeted subset of compelling variants based upon published biologic evidence and their own knowledge of disease biology. Users can also probe variants from multiple biologic standpoints, examine different biologic theories, and identify the most promising variants for follow-up analysis.

Up to now, thousands of users from leading institutions around the world have already uploaded genomic data using Ingenuity variant analysis, which has been used to analyze more than 45,000 biologic samples. In February 2013, Ingenuity had passed an audit under the US Health Insurance Portability and Accountability Act (HIPAA) and complies with the US-EU Safe Harbor framework.

Ingenuity will substantially expand and strengthen Qiagen’s own curated database, which is embedded in wet lab assays and marketed through Qiagen’s GeneGlobe content portal. GeneGlobe offers hundreds of assay panels for polymerase chain reaction (PCR) and NGS as well as more than 60,000 fully annotated molecular assays for the most sought-after diseases and pathways, curated from the biomedical literature.

Related Links:



view channel
Image: Micrograph showing immunofluorescence of skin differentiation markers for basal keratinocytes (Photo courtesy of Dr. Russ Carstens, University of Pennsylvania).

Alternate Splicing Proteins Critically Linked to Skin and Organ Development

Two proteins that regulate alternative splicing in epithelial cells have been linked to the proper development of the skin and protective layers that surround other organs in the body. Two steps are... Read more

Drug Discovery

view channel
Image: Use of catchphrase terms like “breakthrough” and “promising” in public news media presenting new drugs tends to result in incorrect assumptions and conclusions about the meaning and significance of criteria for FDA breakthrough-designated and accelerated-approval drugs (Photo courtesy of Dartmouth Institute).

Words That Inappropriately Enhance Perception of New Drug’s Effectiveness

Researchers have found that using the words “breakthrough” and “promising” in presenting a new drug to the general public often has a dramatic effect on judgment about its effectiveness.... Read more

Lab Technologies

view channel

New Genomic Research Kit Simplifies Exome Studies

An exciting new tool is now available for biotech researchers working in the field of genomic analysis. The human exome is critical to our genetic make-up and is generally accepted as having the greatest influence on how the genetic blueprint is utilized. The exome is defined as all coding exons in the genome and is... Read more


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.