Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Company Formed to Develop Spore-Based Next-Generation Vaccines

By BiotechDaily International staff writers
Posted on 06 Nov 2012
Scientists at Royal Holloway, University of London (London, UK), have developed a pioneering method of vaccination that served as the basis for receiving private seed investment used to form the new company, Holloway Immunology, to further develop the vaccine technology. The company is currently seeking additional investors to help fast track implementation of this new form of vaccine delivery.

Prof. Simon Cutting led the development using probiotic spores. He and his laboratory had been carrying out fundamental biology studies of Bacillus subtilis, which forms spores that can last millions of years before germinating under appropriate conditions. They later found that Bacillus spores can also act as effective vehicles to carry antigens and promote an immune response. "Rather than requiring needle delivery, vaccines based on Bacillus spores can be delivered via a nasal spray, or as an oral liquid or capsule. Alternatively, they can be administered via a small soluble film placed under the tongue [...]. As spores are exceptionally stable, vaccines based on Bacillus do not require cold-chain storage, alleviating a further issue with current vaccine approaches," explained Prof. Cutting. Besides eliminating pain associated with needles, oral vaccines are also safer to administer (especially in developing countries), inexpensive to produce, easier to store, and reduce concerns of adverse reactions.

Prof. Cutting and his team have carried out preclinical evaluation of Bacillus-based vaccines for a number of diseases including tuberculosis (TB), influenza, and tetanus. A Bacillus-based vaccine could boost the immunity provided by, or possibly even replace, existing vaccines against these diseases. They have also begun investigating the potential use of this technology against Clostridium difficile. “There is no vaccine against the disease, and although several approaches are currently undergoing clinical trials, none are expected to provide full protection," said Prof. Cutting. Also, unlike other current approaches, oral delivery can cause a more specific immune response in the gastrointestinal tract to more effectively eliminate C.difficile.

Holloway Immunology will initially concentrate development of the Bacillus spore based technology for three lead vaccines: against TB, influenza, and C. difficile.

Related Links:

Royal Holloway, University of London






Channels

Drug Discovery

view channel
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C (SapC) and the phospholipid dioleoylphosphatidylserine (DOPS) were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Lab Technologies

view channel
Image: The FLUOVIEW FVMPE-RS Gantry microscope (Photo courtesy of Olympus).

New Multiphoton Laser Scanning Microscope Configurations Expand Research Potential

Two new configurations of a state-of-the-art multiphoton laser scanning microscope extend the usefulness of the instrument for examining rapidly occurring biological events and for obtaining images from... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.