Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Fructose Effects on Brain Influence Overeating

By BiotechDaily International staff writers
Posted on 14 Jan 2013
A new study suggests that consuming fructose appears to cause changes in regional cerebral blood flow (CBF) that can lead to overeating.

Researchers at Yale University (New Haven, CT, USA) used arterial spin labeling magnetic resonance imaging (MRI) to quantify regional CBF in 20 healthy normal-weight adult volunteers, both before and after drinking a 75-gram beverage of pure glucose or fructose. The main outcome measures were relative changes in hypothalamic regional CBF after ingestion. Secondary outcomes included whole-brain analyses to explore regional CBF changes, functional connectivity analysis to investigate correlations between the hypothalamus and other brain region responses, and hormone responses to fructose and glucose ingestion.

The results showed that glucose ingestion increased functional connectivity between the hypothalamus and the thalamus and striatum, while fructose increased connectivity between the hypothalamus and thalamus, but not the striatum. Regional CBF within the hypothalamus, thalamus, insula, anterior cingulate, and striatum--the appetite and reward regions-- was reduced after glucose ingestion; in contrast, fructose reduced regional CBF in the thalamus, hippocampus, posterior cingulate cortex, fusiform, and visual cortex. Fructose ingestion was also associated with reduced systemic levels of the satiety-signaling hormone insulin. The study was published in the January 2, 2012, issue of the Journal of the American Medical Association (JAMA).

“Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety,” concluded lead author Kathleen Page, MD, and colleagues. “Thus, fructose possibly increases food-seeking behavior and increases food intake.”

Fructose (fruit sugar) is a simple monosaccharide found in many plants and together with glucose forms sucrose, the sugar we eat. It is one of the three dietary monosaccharides, along with glucose and galactose, which are absorbed directly into the bloodstream during digestion. Because fructose is metabolized in the liver to glucose, it has the lowest glycemic index (19) of all the natural sugars. Excess fructose consumption has been hypothesized to be a cause of insulin resistance, obesity, elevated LDL cholesterol, and triglycerides, leading to metabolic syndrome.

Related Links:
Yale University



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: A leukemia cell coated with antibody is marked for destruction by activated natural killer cells (Photo courtesy of the University of Southern California).

Leukemia Cells Are Killed in Culture by Immune Cells Grown from the Same Patient

Immune system natural killer (NK) cells were isolated from leukemia patients, expanded in culture, and then shown in an in vitro system to attack and destroy cancer cells from the original cell donors.... Read more

Drug Discovery

view channel
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions. To promote development... Read more

Therapeutics

view channel
Image: Liver cells regenerated in mice treated with a new drug (right) compared with a control group (center) after partial liver removal. Healthy liver cells are shown at left (Photo courtesy of Marshall et al, 2014, the Journal of Experimental Medicine).

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice. Liver cancer often results... Read more

Lab Technologies

view channel

White-Matter Deficits Found in Codeine-Containing Cough Syrup Users

A magnetic resonance imaging (MRI) study of chronic users of codeine-containing cough syrups (CCS) has found deficits in specific regions of brain white matter and linked these changes with increased impulsivity in codeine-containing cough syrup users. These findings were consistent with findings from earlier research of... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.