Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Fructose Effects on Brain Influence Overeating

By BiotechDaily International staff writers
Posted on 14 Jan 2013
A new study suggests that consuming fructose appears to cause changes in regional cerebral blood flow (CBF) that can lead to overeating.

Researchers at Yale University (New Haven, CT, USA) used arterial spin labeling magnetic resonance imaging (MRI) to quantify regional CBF in 20 healthy normal-weight adult volunteers, both before and after drinking a 75-gram beverage of pure glucose or fructose. The main outcome measures were relative changes in hypothalamic regional CBF after ingestion. Secondary outcomes included whole-brain analyses to explore regional CBF changes, functional connectivity analysis to investigate correlations between the hypothalamus and other brain region responses, and hormone responses to fructose and glucose ingestion.

The results showed that glucose ingestion increased functional connectivity between the hypothalamus and the thalamus and striatum, while fructose increased connectivity between the hypothalamus and thalamus, but not the striatum. Regional CBF within the hypothalamus, thalamus, insula, anterior cingulate, and striatum--the appetite and reward regions-- was reduced after glucose ingestion; in contrast, fructose reduced regional CBF in the thalamus, hippocampus, posterior cingulate cortex, fusiform, and visual cortex. Fructose ingestion was also associated with reduced systemic levels of the satiety-signaling hormone insulin. The study was published in the January 2, 2012, issue of the Journal of the American Medical Association (JAMA).

“Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety,” concluded lead author Kathleen Page, MD, and colleagues. “Thus, fructose possibly increases food-seeking behavior and increases food intake.”

Fructose (fruit sugar) is a simple monosaccharide found in many plants and together with glucose forms sucrose, the sugar we eat. It is one of the three dietary monosaccharides, along with glucose and galactose, which are absorbed directly into the bloodstream during digestion. Because fructose is metabolized in the liver to glucose, it has the lowest glycemic index (19) of all the natural sugars. Excess fructose consumption has been hypothesized to be a cause of insulin resistance, obesity, elevated LDL cholesterol, and triglycerides, leading to metabolic syndrome.

Related Links:
Yale University



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: This micrograph depicts the presence of aerobic Gram-negative Neisseria meningitidis diplococcal bacteria; magnification 1150x (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Infection by Meningitis Bacteria Depends on Dimerization State of Certain Host Cell Proteins

A team of molecular microbiologists has untangled the complex three-way interaction between the non-integrin laminin receptor (LAMR1), galectin-3 (Gal-2), and the pathogenic bacterium Neisseria meningitidis.... Read more

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Lab Technologies

view channel
Image: Yale West Campus is organized into research institutes and core facilities — all designed to promote collaboration and interdisciplinary dialogue (Photo courtesy of Yale University).

American and European Partners Establish a Microscopy Center of Excellence

A prominent American university has announced a partnership agreement with a major European producer of microscopes and imaging tools that will establish a center for the use of cutting-edge imaging technologies... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.