Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Fructose Effects on Brain Influence Overeating

By BiotechDaily International staff writers
Posted on 14 Jan 2013
A new study suggests that consuming fructose appears to cause changes in regional cerebral blood flow (CBF) that can lead to overeating.

Researchers at Yale University (New Haven, CT, USA) used arterial spin labeling magnetic resonance imaging (MRI) to quantify regional CBF in 20 healthy normal-weight adult volunteers, both before and after drinking a 75-gram beverage of pure glucose or fructose. The main outcome measures were relative changes in hypothalamic regional CBF after ingestion. Secondary outcomes included whole-brain analyses to explore regional CBF changes, functional connectivity analysis to investigate correlations between the hypothalamus and other brain region responses, and hormone responses to fructose and glucose ingestion.

The results showed that glucose ingestion increased functional connectivity between the hypothalamus and the thalamus and striatum, while fructose increased connectivity between the hypothalamus and thalamus, but not the striatum. Regional CBF within the hypothalamus, thalamus, insula, anterior cingulate, and striatum--the appetite and reward regions-- was reduced after glucose ingestion; in contrast, fructose reduced regional CBF in the thalamus, hippocampus, posterior cingulate cortex, fusiform, and visual cortex. Fructose ingestion was also associated with reduced systemic levels of the satiety-signaling hormone insulin. The study was published in the January 2, 2012, issue of the Journal of the American Medical Association (JAMA).

“Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety,” concluded lead author Kathleen Page, MD, and colleagues. “Thus, fructose possibly increases food-seeking behavior and increases food intake.”

Fructose (fruit sugar) is a simple monosaccharide found in many plants and together with glucose forms sucrose, the sugar we eat. It is one of the three dietary monosaccharides, along with glucose and galactose, which are absorbed directly into the bloodstream during digestion. Because fructose is metabolized in the liver to glucose, it has the lowest glycemic index (19) of all the natural sugars. Excess fructose consumption has been hypothesized to be a cause of insulin resistance, obesity, elevated LDL cholesterol, and triglycerides, leading to metabolic syndrome.

Related Links:
Yale University



Channels

Genomics/Proteomics

view channel
Image: In mice, mitochondria (green) in healthy (left) and Mfn1-deficient heart muscle cells (center) are organized in a linear arrangement, but the organelles are enlarged and disorganized in Mfn2-deficient cells (right) (Photo courtesy of the Rockefeller Press).

Cell Biologists Find That Certain Mitochondrial Diseases Stem from Coenzyme Q10 Depletion

A team of German cell biologists has linked the development of certain mitochondrial-linked diseases to depletion of the organelles' pool of coenzyme Q10 brought about by mutation in the MFN2 gene, which... Read more

Drug Discovery

view channel
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C (SapC) and the phospholipid dioleoylphosphatidylserine (DOPS) were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.... Read more

Lab Technologies

view channel
Image: The FLUOVIEW FVMPE-RS Gantry microscope (Photo courtesy of Olympus).

New Multiphoton Laser Scanning Microscope Configurations Expand Research Potential

Two new configurations of a state-of-the-art multiphoton laser scanning microscope extend the usefulness of the instrument for examining rapidly occurring biological events and for obtaining images from... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.