Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Aged Cells Retain Capacity for Rejuvenation via Enhanced Extracellular Support

By BiotechDaily International staff writers
Posted on 19 Dec 2012
Researchers have found that aged human skin fibroblasts retain their capacity for a high degree of reactivation and that this capacity can be significantly restored simply by enhancing the aged extracellular structural support.

In an independent study at the University of Michigan Medical School’s Department of Dermatology (Ann Arbor, MI, USA), scientists have succeeded in making the skin cells of senior citizens behave much like younger cells again by adding more fiber filler to the aging scaffold supporting the cells. The study gives a new perspective on the importance of the extracellular matrix (ECM) in the aging process of skin and possibly also in other types of tissue.

The dermal ECM provides strength and resiliency to skin and consists mostly of type I collagen fibrils produced by the fibroblasts. With aging, ECM collagen fragmentation results in reduced fibroblast cell function and in cell shrinkage. In the study, injection of cross-linked hyaluronic acid (a dermal filler that enhances ECM mechanical support and is commonly used to treat aging facial skin) into the buttock skin of 21 individual volunteers about 80 years of age, or into dermal-equivalent cultures, stimulated TGF-β signaling-dependent production of type I collagen and fibroblast elongation. Also observed in vivo were fibroblast proliferation, expanded vasculature, and increased epidermal thickness. Over three months, the fibroblasts showed increased expression of collagen-related genes, produced more collagen, and bound more effectively to the ECM.

“This shows that skin cells in elderly people have the capacity to respond robustly in a very positive way to alterations in the mechanical property of their environment,” said senior author Gary Fisher, PhD and Harry Helfman professor of Molecular Dermatology. “By altering the matrix using an external filler and increasing the internal pressure, we’ve shown that we can essentially trigger a signal for cells to wake up,” said Prof. Fisher. However, he cautions that the new work does not suggest that cosmetic filler should be used throughout the body. Rather, the importance of the discovery lies mainly in the potential to harness the broader understanding of the ECM for prevention and for more effective therapeutic strategies; such as in relating to skin thinning due to aging, for example, which leaves skin more prone to tearing and interferes with healing after incisions or injury.

The study was reported October 25, 2012, in the Journal of Investigative Dermatolology advance online publication.

Related Links:

University of Michigan Medical School, Dept. of Dermatology



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: A leukemia cell coated with antibody is marked for destruction by activated natural killer cells (Photo courtesy of the University of Southern California).

Leukemia Cells Are Killed in Culture by Immune Cells Grown from the Same Patient

Immune system natural killer (NK) cells were isolated from leukemia patients, expanded in culture, and then shown in an in vitro system to attack and destroy cancer cells from the original cell donors.... Read more

Drug Discovery

view channel
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions. To promote development... Read more

Lab Technologies

view channel

White-Matter Deficits Found in Codeine-Containing Cough Syrup Users

A magnetic resonance imaging (MRI) study of chronic users of codeine-containing cough syrups (CCS) has found deficits in specific regions of brain white matter and linked these changes with increased impulsivity in codeine-containing cough syrup users. These findings were consistent with findings from earlier research of... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.