Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Diabetes Drug Decreases Psychostimulant Addiction Behavior

By BiotechDaily International staff writers
Posted on 06 Nov 2012
Print article
Researchers report a drug currently used for the medical management of type 2 diabetes could also be effective for treating addiction to often-abused psychostimulants.

Researchers from Vanderbilt University (Nashville, TN, USA) have found that a brain mechanism known to be a therapeutic target in treating type 2 diabetes mellitus also appears to be involved in some forms of drug addiction. In a study of cocaine addiction, animals were injected with the diabetes drug Exendin-4, a longer-lasting analog of the natural hormone glucagon-like peptide-1 (GLP-1), which is released in response to nutrient ingestion and is a regulator of energy metabolism and feeding behavior. The resulting behavior showed significant reduction of the rewarding effects of cocaine and the findings were consistent over a broad range of Exendin-4 dosage. The study reported no evidence of negative side effects or addiction to Exendin-4 treatment.

“We suspect that this is a general mechanism that will translate to additional drugs of abuse, especially other stimulants, like amphetamine and methamphetamine,” said Gregg Stanwood, PhD, assistant professor of Pharmacology and an investigator in the Vanderbilt Kennedy Center and Vanderbilt Brain Institute. "I think the power of this research is that it is so easily translatable to humans because [Extendin-4] is already FDA approved [for diabetes]," said Aurelio Galli, PhD, professor of Molecular Physiology and Biophysics, Vanderbilt Brain Institute investigator, and codirector of the Neuroscience Program in Substance Abuse. "Any disease that is based on dysregulated dopamine can be potentially targeted. There is a lot of comorbidity between metabolic disorders like diabetes and obesity and psychiatric disease like addiction and schizophrenia."

Prof. Stanwood noted that although it is important to be very cautious in extrapolating the results to humans, these are encouraging data. “There are no medically based therapies for stimulant addiction that have been successful in the clinic, although there are a variety of psychosocial and behavioral therapies that are somewhat effective in some people,” said Prof. Stanwood. “The beauty of this is that it targets a completely new mechanism so we are cautiously hopeful [...]. We don’t expect this to be a magic bullet where one can simply take this drug and their addiction goes away, but hopefully a medicine like this, in combination with social and behavioral support, will help an addict on the road to recovery.”

The findings were published early online October 23, 2012, in the journal Molecular Psychiatry.

Related Links:

Vanderbilt University



Print article

Channels

Genomics/Proteomics

view channel
Image: The green-labeled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red (Photo courtesy of Adriana Sánchez-Danés, Université Libre de Bruxelles).

Stem Cells Not Progenitors Can Trigger Skin Cancer Growth

Cancer researchers have discovered that stem cells can initiate development of malignant skin tumors, while progenitor cells are limited to triggering only benign growths. A progenitor cell is similar... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel
Image: A 3D nanofiber net formed by the supergelators to trap oil molecules (Photo courtesy of IBN at A*STAR / Institute of Bioengineering and Nanotechnology).

Effective Cleanup with Smart Material That Forms Oil-Trapping Net

Researchers have developed supergelators – an organic oil-scavenging material that rapidly forms a 3D net to trap oil molecules, gelatinizing into solidified masses that can be more easily removed from... Read more

Business

view channel

Sartorius Acquires US Start-up ViroCyt

Sartorius AG (Göttingen, Germany), a pharmaceutical and laboratory equipment provider, has acquired ViroCyt Incorporated (Broomfield, CO, USA), a start-up in the field of rapid virus quantification, in a deal valued at approximately USD 16 million. ViroCyt’s automated platform integrates instruments, software and reagents... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.