Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016

Common Anti-Inflammatory Drugs Associated With Decreased Risk of Skin Cancer

By BiotechDaily International staff writers
Posted on 12 Jun 2012
Print article
A new study has found an association linking the use of various nonsteroidal anti-inflammatory drugs (NSAIDs) with a decreased risk of two major types of skin cancer.

Researchers at Aarhus University Hospital (Aarhus, Denmark) undertook a retrospective, population-based case-control study of patients in Northern Denmark to examine the association between use of NSAIDs--including aspirin, ibuprofin, and naproxen--and the risk of squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and malignant melanoma (MM). Analysis of medical records from northern Denmark from 1991 through 2009 identified 1,974 diagnoses of SSC, 13,316 diagnoses of BCC, and 3,242 diagnoses of MM. Drug use information (including prescription data) from these patients was compared with information from 178,655 individuals without skin cancer.

Statistical analyses indicated that individuals who filled more than two prescriptions for NSAIDs had a 15% decreased risk for developing SCC and a 13% decreased risk for developing MM than those who filled two or fewer prescriptions for the medications, especially when the drugs were taken for seven or more years or taken at high intensity. Taking NSAIDs did not seem to reduce the risk of developing BCC in general, although there was a 15% and 21% reduced risk of developing BCC on less-exposed sites (body areas other than the head and neck) when the drugs were taken long term or at high intensity, respectively.

The main SCC and MM risk-reducers in the study were nonselective NSAIDs and older COX-2 inhibitors (diclofenac, etodolac, and meloxicam). NSAIDs are thought to help prevent the development of cancer by inhibiting cyclooxygenase (COX) enzymes, which are known to be involved in carcinogenesis.

“We hope that the potential cancer-protective effect of NSAIDs will inspire more research on skin cancer prevention,” said first author Sigrún Alba Jóhannesdóttir, BSc, of the Department of Clinical Epidemiology at Aarhus University Hospital; “Also, [this] effect should be taken into account when discussing benefits and harms of NSAID use.”

Related Links:
Aarhus University Hospital



Print article

Channels

Genomics/Proteomics

view channel
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.