Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Circadian Rhythms Strongly Influence Key Metabolic Pathways

By BiotechDaily International staff writers
Posted on 17 May 2012
By analyzing hundreds of metabolic products, researchers have discovered that circadian rhythms greatly control the production of such key building blocks as amino acids, carbohydrates, and lipids. The findings also led to the world’s first comprehensive liver metabolite map.

Of the more than 600 liver-originated metabolites identified in the study, approximately 60% were found to be dependent on the endogenous circadian clock--many more than expected, as only about 15 % of the body’s known genes have been shown to be regulated by it.

This 24-hour biologic clock governs fundamental cellular processes and adapts certain bodily functions to the appropriate time of day. Disruption of these cycles can seriously affect human health. Dr. Paolo Sassone-Corsi, lead author of the study and director of the Center for Epigenetics & Metabolism at the University of California, Irvine (UCI; USA), reported that this investigation liver metabolites revealed how the clock--through the main circadian gene, CLOCK--orchestrates the interplay between metabolites and signaling proteins.

Since external cues, such as day-night lighting patterns and nutrition, influence the circadian machinery, metabolites and their relationship to signaling proteins seem to be acutely tied to circadian disruption and may be associated with primary factors underlying metabolic-based diseases like diabetes. “This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism,” said Dr. Sassone-Corsi.

Working with scientists from Metabolon, Inc. (Durham, NC, USA; www.metabolon.com), Sassone-Corsi and Kristin Eckel-Mahan, a UCI postdoctoral researcher and study coauthor, created the first liver metabolome--a dataset of liver metabolites. With this information, they also partnered with Dr. Pierre Baldi, director of UCI’s Institute for Genomics & Bioinformatics, and his graduate student Vishal Patel to analyze the data and build CircadiOmics, a Web-based data system that provides detailed profiles of metabolites and related genes, and the underlying networks through which they interact. “Within CircadiOmics, we were able to integrate this circadian metabolite data with multiple other data sources to generate the first comprehensive map of the liver metabolome and its circadian oscillations, and to develop regulatory hypotheses that have been confirmed in the laboratory,” said Dr. Baldi.

The integrated map illustrates how the circadian metabolome, transcriptome, and proteome are connected through specific nodes that operate in concert to achieve metabolic homeostasis. “CircadiOmics is being expanded with metabolic data about other tissues and conditions, and will be invaluable to further our understanding of the interplay between metabolism and circadian rhythms in healthy and diseased states,” Dr. Baldi added.

The study appeared in the March, 2012, early online edition of the Proceedings of the [U.S.] National Academy of Sciences USA.

Related Links:

University of California at Irvine

Metabolon





WATERS CORPORATION

Channels

Genomics/Proteomics

view channel
Image: Mosquitoes are known to infect people and animals with West Nile virus. Studying West Nile virus infection in mice, researchers have shown that the antiviral compound interferon-lambda tightens the blood-brain barrier, making it harder for the virus to invade the brain (Photo courtesy of the CDC – [US] Centers for Disease Control and Prevention).

Interferon-Lambda Prevents West Nile Virus from Crossing the Blood-brain Barrier

The cytokine interferon-lambda prevents West Nile virus from infecting brain cells by reducing transport of large molecules across the blood-brain barrier. Although interferon-lambda [also known as... Read more

Drug Discovery

view channel
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease (AD) in a mouse model.... Read more

Lab Technologies

view channel
Image: The gene assembly robot, the GeneTheatre (Photo courtesy of Analytik Jena AG).

Genomic Research Laboratories Await New Compact Liquid Handling System

A small footprint benchtop liquid handler that automates multiple gene assembly tasks and associated procedures such as PCR setup is now available for use by biotech and genomic research laboratories.... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 

Events

27 May 2015 - 28 May 2015
02 Jun 2015 - 03 Jun 2015
15 Jun 2015 - 18 Jun 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.