Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Circadian Rhythms Strongly Influence Key Metabolic Pathways

By BiotechDaily International staff writers
Posted on 17 May 2012
By analyzing hundreds of metabolic products, researchers have discovered that circadian rhythms greatly control the production of such key building blocks as amino acids, carbohydrates, and lipids. The findings also led to the world’s first comprehensive liver metabolite map.

Of the more than 600 liver-originated metabolites identified in the study, approximately 60% were found to be dependent on the endogenous circadian clock--many more than expected, as only about 15 % of the body’s known genes have been shown to be regulated by it.

This 24-hour biologic clock governs fundamental cellular processes and adapts certain bodily functions to the appropriate time of day. Disruption of these cycles can seriously affect human health. Dr. Paolo Sassone-Corsi, lead author of the study and director of the Center for Epigenetics & Metabolism at the University of California, Irvine (UCI; USA), reported that this investigation liver metabolites revealed how the clock--through the main circadian gene, CLOCK--orchestrates the interplay between metabolites and signaling proteins.

Since external cues, such as day-night lighting patterns and nutrition, influence the circadian machinery, metabolites and their relationship to signaling proteins seem to be acutely tied to circadian disruption and may be associated with primary factors underlying metabolic-based diseases like diabetes. “This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism,” said Dr. Sassone-Corsi.

Working with scientists from Metabolon, Inc. (Durham, NC, USA; www.metabolon.com), Sassone-Corsi and Kristin Eckel-Mahan, a UCI postdoctoral researcher and study coauthor, created the first liver metabolome--a dataset of liver metabolites. With this information, they also partnered with Dr. Pierre Baldi, director of UCI’s Institute for Genomics & Bioinformatics, and his graduate student Vishal Patel to analyze the data and build CircadiOmics, a Web-based data system that provides detailed profiles of metabolites and related genes, and the underlying networks through which they interact. “Within CircadiOmics, we were able to integrate this circadian metabolite data with multiple other data sources to generate the first comprehensive map of the liver metabolome and its circadian oscillations, and to develop regulatory hypotheses that have been confirmed in the laboratory,” said Dr. Baldi.

The integrated map illustrates how the circadian metabolome, transcriptome, and proteome are connected through specific nodes that operate in concert to achieve metabolic homeostasis. “CircadiOmics is being expanded with metabolic data about other tissues and conditions, and will be invaluable to further our understanding of the interplay between metabolism and circadian rhythms in healthy and diseased states,” Dr. Baldi added.

The study appeared in the March, 2012, early online edition of the Proceedings of the [U.S.] National Academy of Sciences USA.

Related Links:

University of California at Irvine

Metabolon





Channels

Genomics/Proteomics

view channel
Image: In mice, mitochondria (green) in healthy (left) and Mfn1-deficient heart muscle cells (center) are organized in a linear arrangement, but the organelles are enlarged and disorganized in Mfn2-deficient cells (right) (Photo courtesy of the Rockefeller Press).

Cell Biologists Find That Certain Mitochondrial Diseases Stem from Coenzyme Q10 Depletion

A team of German cell biologists has linked the development of certain mitochondrial-linked diseases to depletion of the organelles' pool of coenzyme Q10 brought about by mutation in the MFN2 gene, which... Read more

Drug Discovery

view channel
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C (SapC) and the phospholipid dioleoylphosphatidylserine (DOPS) were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.... Read more

Lab Technologies

view channel
Image: The FLUOVIEW FVMPE-RS Gantry microscope (Photo courtesy of Olympus).

New Multiphoton Laser Scanning Microscope Configurations Expand Research Potential

Two new configurations of a state-of-the-art multiphoton laser scanning microscope extend the usefulness of the instrument for examining rapidly occurring biological events and for obtaining images from... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.