Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Circadian Rhythms Strongly Influence Key Metabolic Pathways

By BiotechDaily International staff writers
Posted on 17 May 2012
Print article
By analyzing hundreds of metabolic products, researchers have discovered that circadian rhythms greatly control the production of such key building blocks as amino acids, carbohydrates, and lipids. The findings also led to the world’s first comprehensive liver metabolite map.

Of the more than 600 liver-originated metabolites identified in the study, approximately 60% were found to be dependent on the endogenous circadian clock--many more than expected, as only about 15 % of the body’s known genes have been shown to be regulated by it.

This 24-hour biologic clock governs fundamental cellular processes and adapts certain bodily functions to the appropriate time of day. Disruption of these cycles can seriously affect human health. Dr. Paolo Sassone-Corsi, lead author of the study and director of the Center for Epigenetics & Metabolism at the University of California, Irvine (UCI; USA), reported that this investigation liver metabolites revealed how the clock--through the main circadian gene, CLOCK--orchestrates the interplay between metabolites and signaling proteins.

Since external cues, such as day-night lighting patterns and nutrition, influence the circadian machinery, metabolites and their relationship to signaling proteins seem to be acutely tied to circadian disruption and may be associated with primary factors underlying metabolic-based diseases like diabetes. “This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism,” said Dr. Sassone-Corsi.

Working with scientists from Metabolon, Inc. (Durham, NC, USA; www.metabolon.com), Sassone-Corsi and Kristin Eckel-Mahan, a UCI postdoctoral researcher and study coauthor, created the first liver metabolome--a dataset of liver metabolites. With this information, they also partnered with Dr. Pierre Baldi, director of UCI’s Institute for Genomics & Bioinformatics, and his graduate student Vishal Patel to analyze the data and build CircadiOmics, a Web-based data system that provides detailed profiles of metabolites and related genes, and the underlying networks through which they interact. “Within CircadiOmics, we were able to integrate this circadian metabolite data with multiple other data sources to generate the first comprehensive map of the liver metabolome and its circadian oscillations, and to develop regulatory hypotheses that have been confirmed in the laboratory,” said Dr. Baldi.

The integrated map illustrates how the circadian metabolome, transcriptome, and proteome are connected through specific nodes that operate in concert to achieve metabolic homeostasis. “CircadiOmics is being expanded with metabolic data about other tissues and conditions, and will be invaluable to further our understanding of the interplay between metabolism and circadian rhythms in healthy and diseased states,” Dr. Baldi added.

The study appeared in the March, 2012, early online edition of the Proceedings of the [U.S.] National Academy of Sciences USA.

Related Links:

University of California at Irvine

Metabolon





Print article

Channels

Genomics/Proteomics

view channel
Image: An artistic rendering of the Zika virus structure (Photo courtesy of Dr. Guntur Fibriansah, Duke-NUS Medical School).

High Resolution Structure of Zika virus Expected to Aid Vaccine Development

A team of molecular virologists used advanced cryo-electron microscopy techniques to establish a high-resolution structure for the Zika virus, a formerly neglected pathogen that has recently been associated... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.