Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
JIB
GLOBETECH PUBLISHING

Leukemia Breast Cancers Suppressed by Single Protein

By BiotechDaily International staff writers
Posted on 02 Feb 2012
Targeting a single protein can help combat both breast cancers and leukemia, according to two new reports. The single protein, HSP90, acts as a chaperone to protect other cellular proteins.

The study’s findings were published online January 23, 2012, in the Journal of Experimental Medicine. A team of investigators led by Ute Moll from the University of Gottingen (Germany) discovered that suppressing HSP90 activity rendered normally protected proteins susceptible to attack and destruction. One of these proteins--called migration inhibitory factor--fuels the growth of breast tumors. HSP90 inhibitors slowed the growth of migration inhibitory factor (MIF)-expressing breast tumors in mice but had little effect on tumors lacking MIF.

HSP90 inhibitors also look promising for certain forms of leukemia, according to a study by David Weinstock and coworkers at the Dana-Farber Cancer Institute (Boston, MA, USA). They demonstrated that HSP90 inhibitors slowed the growth of leukemia driven by hyperactive versions of the enzyme JAK2 (Janus kinase 2), many of which become resistant to JAK2-blocking drugs. The HSP90 inhibitors delayed the growth of resistant leukemia cells in mice.

According to the scientists, this research suggests that HSP90 may represent a therapeutic target for a range of cancers.

Related Links:

University of Göttingen
Dana-Farber Cancer Institute





comments powered by Disqus

Channels

Drug Discovery

view channel
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions. To promote development... Read more

Therapeutics

view channel
Image: Liver cells regenerated in mice treated with a new drug (right) compared with a control group (center) after partial liver removal. Healthy liver cells are shown at left (Photo courtesy of Marshall et al, 2014, the Journal of Experimental Medicine).

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice. Liver cancer often results... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.