Features | Partner Sites | Information | LinkXpress
Sign In
Demo Company

Leukemia Breast Cancers Suppressed by Single Protein

By BiotechDaily International staff writers
Posted on 02 Feb 2012
Targeting a single protein can help combat both breast cancers and leukemia, according to two new reports. The single protein, HSP90, acts as a chaperone to protect other cellular proteins.

The study’s findings were published online January 23, 2012, in the Journal of Experimental Medicine. A team of investigators led by Ute Moll from the University of Gottingen (Germany) discovered that suppressing HSP90 activity rendered normally protected proteins susceptible to attack and destruction. One of these proteins--called migration inhibitory factor--fuels the growth of breast tumors. HSP90 inhibitors slowed the growth of migration inhibitory factor (MIF)-expressing breast tumors in mice but had little effect on tumors lacking MIF.

HSP90 inhibitors also look promising for certain forms of leukemia, according to a study by David Weinstock and coworkers at the Dana-Farber Cancer Institute (Boston, MA, USA). They demonstrated that HSP90 inhibitors slowed the growth of leukemia driven by hyperactive versions of the enzyme JAK2 (Janus kinase 2), many of which become resistant to JAK2-blocking drugs. The HSP90 inhibitors delayed the growth of resistant leukemia cells in mice.

According to the scientists, this research suggests that HSP90 may represent a therapeutic target for a range of cancers.

Related Links:

University of Göttingen
Dana-Farber Cancer Institute



view channel
Image: Micrograph showing immunofluorescence of skin differentiation markers for basal keratinocytes (Photo courtesy of Dr. Russ Carstens, University of Pennsylvania).

Alternate Splicing Proteins Critically Linked to Skin and Organ Development

Two proteins that regulate alternative splicing in epithelial cells have been linked to the proper development of the skin and protective layers that surround other organs in the body. Two steps are... Read more

Drug Discovery

view channel
Image: Endoscopic image of a bowel section known as the sigmoid colon afflicted with ulcerative colitis. The internal surface of the colon is blotchy and broken in places (Photo courtesy of Wikimedia Commons).

Orally Delivered Curcumin-Loaded Microparticles Effectively Treat Mouse Model of Ulcerative Colitis

Microparticles (MPs) loaded with the efficient anti-inflammatory agent curcumin were found to effectively treat a mouse model of ulcerative colitis. Ulcerative colitis is a chronic relapsing disease... Read more

Lab Technologies

view channel

New Genomic Research Kit Simplifies Exome Studies

An exciting new tool is now available for biotech researchers working in the field of genomic analysis. The human exome is critical to our genetic make-up and is generally accepted as having the greatest influence on how the genetic blueprint is utilized. The exome is defined as all coding exons in the genome and is... Read more


view channel

Collaboration Agreement to Boost Discovery of Fully Human Antibodies for Therapeutic Use

The discovery of fully human antibodies for therapeutic use will be boosted by a recently announced collaboration between a major university research center and a dynamic biopharmaceutical development company. Regeneron Pharmaceuticals, Inc. (Tarrytown, New York, USA) and The Experimental Therapeutics Institute (ETI)... Read more


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.