Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
BioConferenceLive

Erythropoietin Found Involved in Origin and Metastasis of Cancer

By BiotechDaily International staff writers
Posted on 19 Dec 2011
Researchers have demonstrated that a platelet-derived growth factor-BB (PDGF-BB) and the blood protein erythropoietin (EPO) are involved in the development of cancerous tumors and that they combine to help the tumors flourish in the body. These new preclinical findings offer new potential for suppressing tumor growth and bypassing difficulties of resistance that exist with many drugs in current use.

The study’s findings were published online December 4, 2011, in the journal Nature Medicine. Angiogenesis is the formation of new blood vessels from preexisting ones, and is one of the most important research fields in the treatment of such diverse disorders such as cancer, metastases, obesity, heart disease, stroke, diabetes, and chronic inflammation. The process is also important in healthy individuals for wound healing, the menstrual cycle, and other normal processes. Prof. Yihai Cao and his coworkers from the Karolinska Institute (Stockholm, Sweden) are examining the angiogenesis process and its ties to cancer and other disorders, and in the present study, they revealed the critical role played by growth factor PDGF-BB.

“It’s a member of the PDGF family and significantly contributes to blood vessel development, which is one of the characteristic signs of cancer,” said Prof. Yihai Cao. Our preclinical findings suggest that PDGF-BB causes systemic effects in the body, which is to say that rather than being active locally it goes into the blood and interferes with the function of several organs so that the entire body is affected.”

The studies were conducted on lab mice, and in this study, the investigators were able to demonstrate that when the growth factor PDGF-BB binds to its receptors, it stimulates the blood protein EPO, which then regulates the production of red blood cells that provide more oxygen for tumor growth and metastasis. “EPO has several functions,” remarked Prof. Cao. “It produces more blood and stimulates angiogenesis, and we have revealed the underlying mechanism. It also stimulates tumor angiogenesis by directly stimulating the proliferation, migration, and growth of endothelial cells and their ability to form the so-called epithelial tube. PDGF-BB promotes the stimulation of extramedullary hematopoiesis, enlargement of the liver and spleen, which increases oxygen perfusion and protection against anemia.”

The introduction of PDGF-BB in mice therefore increases erythropoietin production and the hematopoietic parameters. Moreover, EPO may directly act on tumor cells to stimulate their growth and metastasis. “We believe that the increase in EPO might be responsible for tumoral resistance to antiangiogenetic drugs, which only target PDGF ligands. The combination of drugs targeted at both PDGF and EPO has potential superior therapeutic benefits,” stated Prof. Yihai Cao, adding that they will continue to research mouse models and assess opportunities for clinical studies on patients.

Prof. Yihai Cao is also affiliated to Linköping University (Linköping, Sweden). Researchers from Karolinska Institute, Linköping University, and the University of Toyama (Toyama, Japan) contributed to the study.

Related Links:

Karolinska Institute
Linköping University
University of Toyama




comments powered by Disqus

Channels

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Lab Technologies

view channel
Image: A one-year-old baby sits in a brain scanner, called magnetoencephalography (MEG)—a noninvasive approach to measuring brain activity. The baby listens to speech sounds such as “da” and “ta” played over headphones while researchers record her brain responses (Photo courtesy of the Institute for Learning & Brain Sciences at the University of Washington).

Brain Scanner Shows Infants’ Brains Rehearse Speech Sounds Months Before Their First Words

New research in 7- and 11-month-old infants revealed that speech sounds stimulate brain regions that coordinate and plan motor movements for speech. The new study suggests that babies’ brains begin establishing... Read more

Business

view channel

Cancer Immunotherapy Sector Predicted to Surge to USD 9 Billion Across Major Pharma Through 2022

The immunotherapy market will experience substantial growth through 2022, increasing from USD 1.1 billion in 2012 to nearly USD 9 billion in 2022 (corresponding to 23.8% annual growth) in the United Kingdom, United States, France, Germany, Italy, Spain, and Japan, according to recent market research. This notable growth... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.