Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Antimicrobial Hydrogels Dissolve and Sterilize Drug-Resistant Biofilms

By BiotechDaily International staff writers
Posted on 04 Feb 2013
Image: The polymer solution is free flowing (b, d) at room temperature (25 °C). When heated to body temperature (37 °C), the polymers self-assemble into a cross-linked network, causing the solution to form a gel (c, e) (Photo courtesy of IBM).
Image: The polymer solution is free flowing (b, d) at room temperature (25 °C). When heated to body temperature (37 °C), the polymers self-assemble into a cross-linked network, causing the solution to form a gel (c, e) (Photo courtesy of IBM).
Image: On the left is a mature and healthy MRSA biofilm. After the hydrogel is applied, the biofilm is destroyed as seen on the right. The small portion of cells left has drastically disrupted membrane, preventing resistance. This type of biofilm disruption has not been reported in other antimicrobial hydrogels/synthetic polymers (Photo courtesy of IBN).
Image: On the left is a mature and healthy MRSA biofilm. After the hydrogel is applied, the biofilm is destroyed as seen on the right. The small portion of cells left has drastically disrupted membrane, preventing resistance. This type of biofilm disruption has not been reported in other antimicrobial hydrogels/synthetic polymers (Photo courtesy of IBN).
Synthetic antimicrobial hydrogels have been developed that demonstrate 100% efficiency in destruction of biofilms, with application potential for catheter and medical device coatings, implants, skin, and everyday surfaces.

Bacterial biofilms, which are adhesive groupings of pathogenic cells present in 80% of all infections, develop on the skin and on medical devices and household surfaces where they are difficult to treat and demonstrate high resistance to antibiotics.

In the current study, which was published in the January 7, 2013, issue of the journal, Angewandte Chemie, investigators at IBM (San Jose, CA, USA) and the Institute of Bioengineering and Nanotechnology (Singapore) described the development of biodegradable and injectable/moldable hydrogels with hierarchical nanostructures. These 90% aqueous hydrogels were made from specifically designed macromolecules containing a large number of atoms, which combined water solubility, positive charge, and biodegradability characteristics. When mixed with water and warmed to body temperature the polymers self-assembled, swelling into a synthetic gel that was easy to manipulate.

The hydrogels were shown to possess broad-spectrum antimicrobial activities and biofilm-disruption capability. Furthermore, they demonstrated no cytotoxicity in vitro, and displayed excellent skin biocompatibility in animals.

"This is a fundamentally different approach to fighting drug-resistant biofilms. When compared to capabilities of modern-day antibiotics and hydrogels, this new technology carries immense potential,” said Dr. James Hedrick, advanced organic materials scientist at IBM. “This new technology is appearing at a crucial time as traditional chemical and biological techniques for dealing with drug-resistant bacteria and infectious diseases are increasingly problematic.”

“We were driven to develop a more effective therapy against super bugs due to the lethal threat of infection by these rapidly mutating microbes and the lack of novel antimicrobial drugs to fight them. Using the inexpensive and versatile polymer materials that we have developed jointly with IBM, we can now launch a nimble, multipronged attack on drug-resistant biofilms which would help to improve medical and health outcomes,” said Dr. Yi-Yan Yang, group leader at the Institute of Bioengineering and Nanotechnology.

Related Links:
IBM
Institute of Bioengineering and Nanotechnology


Channels

Genomics/Proteomics

view channel
Image: In mice, mitochondria (green) in healthy (left) and Mfn1-deficient heart muscle cells (center) are organized in a linear arrangement, but the organelles are enlarged and disorganized in Mfn2-deficient cells (right) (Photo courtesy of the Rockefeller Press).

Cell Biologists Find That Certain Mitochondrial Diseases Stem from Coenzyme Q10 Depletion

A team of German cell biologists has linked the development of certain mitochondrial-linked diseases to depletion of the organelles' pool of coenzyme Q10 brought about by mutation in the MFN2 gene, which... Read more

Drug Discovery

view channel
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C (SapC) and the phospholipid dioleoylphosphatidylserine (DOPS) were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.