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12 Apr 2017 - 14 Apr 2017
22 Apr 2017 - 26 Apr 2017
New products on world’s medical product marketplace:


Image: A confocal microscopy image of human fibroblasts derived from embryonic stem cells. The nuclei appear in blue, while smaller and more numerous mitochondria appear in red (Photo courtesy of Dr. Shoukhrat Mitalipov, Oregon Health & Science University).

Stem Cells Derived from Older Individuals May Carry Unsafe Mitochondrial DNA Mutations

Induced pluripotent stem cells (iPSCs) derived from the skin fibroblasts of older individuals have a likelihood of harboring mitochondrial DNA mutations, which may render them unfit for clinical applications. More...
29 Apr 2016
Image: A small library of abietane-type diterpenoids amides was prepared from the plant-based dehydroabietylamine (left (1)) as a starting material, and the compounds evaluated for activity against Leishmania donovani and Trypanosoma cruzi. One compound (right (10)), an amide built from dehydroabietylamine and acrylic acid, was found to be highly effective against both parasites (Photo courtesy of Pirttimaa M et al., 2016, Journal of Natural Products).

Newly Developed Drug Demonstrates Potent, Selective Activity Against Trypanosomatid Parasites

Using a plant-based compound, scientists have developed a semi-synthetic drug that, upon testing on infected mammalian cells in culture, showed highly effective activity against two parasites from the trypanosomatid family: Leishmania donovani, a cause of visceral leishmaniasis, and Trypanosoma cruzi, cause of Chagas disease.  More...
06 Apr 2016

Link Found Between Brain Metabolism and Fluid Intelligence

By measuring a metabolic activity marker using magnetic resonance spectroscopy, a new study in young adults has indicated that healthy brain metabolism corresponds with fluid intelligence, a measure of one’s ability to solve unusual or complex problems.  More...
03 Apr 2016
Image: Schematic representation of implant for passive immunization by long-term therapeutic antibody delivery. Cells genetically engineered to produce a therapeutic antibody are confined in a macroencapsulation “flat sheet” device and implanted in the subcutaneous tissue for in vivo antibody secretion into the bloodstream. Antibodies reaching the brain target, clear, and prevent the harmful amyloid-beta protein plaques of Alzheimer’s disease (Photo courtesy of Lathuilière A et al, 2016, and Swiss Federal Institute of Technology in Lausanne).

Medical Implant Device Reduces Alzheimer’s Pathology and Provides Passive Immunization

In landmark proof-of-concept study with mice, a cutting-edge subcutaneous-implant capsule developed for treatment for Alzheimer’s disease, successfully directed the immune system against the disease.  More...
03 Apr 2016
Image: A scanning electron microscopic (SEM) image of the microneedle-array beta-cell patch (Photo courtesy of Dr. Zhen Gu, University of North Carolina).

Microneedle Delivery of Beta-Cells Avoids Host Immune Rejection

A novel skin patch filled with living insulin-secreting beta cells was shown to regulate glucose levels in a mouse diabetes model for up to 10 hours while avoiding adverse immune responses.  More...
28 Mar 2016
Image: The three types of heart cells—cardiomyocytes, endothelial cells, and smooth muscle cells—created from ieCPCs (Photo courtesy of Dr. Yu Zhang, Gladstone Institutes).

Stem Cell Therapy Repairs Damaged Heart Muscle in Mouse Myocardial Infarction Model

Advanced stem cell techniques were used to generate expandable cardiovascular progenitor cells from skin fibroblasts, which could repair damage to the heart muscle caused by myocardial infarction.  More...
13 Mar 2016
Image: Reprogrammed stem cells (green) chase down and kill glioblastoma cells (pink), potentially offering a new and more effective treatment option for a disease that has not had any in more than 30 years (Photo courtesy of the University of North Carolina).

Stem Cell Therapies Improve Survival of Mouse Brain Cancer Model

Two papers have described the use of fibrin-embedded, biologically engineered induced neural and mesenchymal stem cells in tumor-homing cytotoxic stem cell therapy that shows promise as a new approach for treating the incurable brain cancer glioblastoma multiforme.  More...
09 Mar 2016

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