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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017


Gene Therapy Prevents Cancer Cells from Surviving in Hypoxic Environment

Gene therapy techniques were used to insert a peptide into cultures of human cancer cells that blocked their ability to use the enzyme Hypoxia-inducible factor-1, a heterodimeric transcription factor that enables cell survival under low oxygen conditions by altering the transcription of over 300 genes. More...
08 Dec 2016

Successful Treatment of Enteritis Due to Newly Discovered Gene Mutation

Researchers report successful treatment of an adult patient with severe chronic autoimmune enteritis by using the drug Vedolizumab to target the effect on T-cell function of a mutation identified in the patient’s CTLA-4 gene. Vedolizumab may also help skin cancer patients with enteritis due to therapy with Ipilimumab. More...
07 Dec 2016

Modified T-Cells Attack Tumors without Triggering Autoimmune Disease

A team of molecular immunologists has devised a method to direct T-cells to recognize and fight cancer cells without risk of the modified cells attacking normal tissues and thereby triggering autoimmune disease. More...
22 Nov 2016
Image: In this image, the top row shows few T-cells in untreated mice, while the bottom rows show many T-cells produced after immunotherapy treatment (Photo courtesy of Massachusetts Institute of Technology).

Novel Immunotherapy Approach Shrinks or Eliminates Advanced Tumors

A novel four-component approach to anti-cancer immunotherapy overcame the complex network of immunosuppressive pathways present in advanced tumors and caused shrinkage of several types of tumors in different mouse models. More...
03 Nov 2016

Desalinated Water Linked to Cases of Iodine Deficiency

A study suggests and warns that relying on desalinated seawater as a population’s main source of drinking water can dramatically increase the prevalence of inadequate iodine intake, recommending individuals use iodized salt or other supplement and monitoring until an effective population-level solution has been found. More...
26 Sep 2016

Human Liver Organoids Thrive When Transplanted into Mouse Liver Failure Model

Liver disease researchers have demonstrated in a mouse model that it may be feasible to treat some types of liver failure with transplanted multicellular liver organoid units composed of a heterogeneous cellular population that includes adult stem and progenitor cells. More...
13 Sep 2016

Novel Human Monoclonal Antibody Shows Promise for Treating Alzheimer's Disease

A human monoclonal antibody that targets aggregated forms of amyloid-beta (Abeta) protein was shown in a phase Ib clinical study to reduce amyloid plaques in patients with early Alzheimer's disease and to slow or prevent cognitive decline in these individuals. More...
12 Sep 2016

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