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Drug Discovery

Image: 3BrPA (red) encased in a sugar-based microshell (Photo courtesy of Dr. Jean-Francois Geschwind, Johns Hopkins University).

New Packaging Revives Potential for Highly Toxic Cancer Drug

Cancer researchers have shown that sequestering the highly toxic drug 3-bromopyruvate in a sugar-based molecular microcapsule protects the drug from being inactivated in the bloodstream and eliminates the toxicity that prevents its general use as a chemotherapeutic agent.  More...
28 Dec 2014
Image: Engineered cationic antimicrobial peptide (eCAP) membrane (Photo courtesy of the University of Pittsburgh School of Medicine).

Synthetic Peptide Drug Overcomes Bacterial Resistance to Antibiotics

A team of molecular microbiologists has demonstrated the potential value of engineered cationic antibiotic peptides for treating infections caused by bacteria that have developed resistance to traditional antibiotics.  More...
23 Dec 2014
Image: The new peptide offers a triple hormone effect in a single-cell molecule (Photo courtesy of Indiana University).

Tripeptide Drug Effectively Controls Metabolic Syndrome in Rodent Model

Promising results in reducing obesity and normalizing glucose metabolism obtained with a synthetic dipeptide drug have been enhanced by the addition of a molecule of a third hormone, glucagon.  More...
21 Dec 2014
Image: Disruption and removal of malaria parasites by the experimental drug (+)-SJ733 (Photo courtesy of the University of California, San Francisco).

Experimental Antimalaria Drug Induces the Immune System to Destroy Infected Red Blood Cells

An experimental drug for the treatment of malaria was found to induce morphological changes in infected erythrocytes that enabled the immune system to recognize and eliminate them.  More...
14 Dec 2014

New Findings May Lead to Enhanced Treatments for Multiple Sclerosis and Autoimmune Inflammation

A multidisciplinary research team of scientists from Singapore has made a breakthrough discovery of a new type of immune cells that may help in the development of a future treatment for multiple sclerosis.  More...
10 Dec 2014

Scientists Unwind More Mysteries of the Cellular Clock

A new study surveying circadian gene expression provides a new understanding of how one clock leads to at least 8 different subclocks, and may suggest a new venue for drug treatment of clock-based metabolic disorders.  More...
08 Dec 2014

Antiangiogenic Treatment Improves Survival of Mice Models of Ovarian Cancer

A new antiangiogenic treatment with 3TSR has been shown to shrink tumors and improves effectiveness of chemotherapy.  More...
08 Dec 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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