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Drug Discovery

Synthetic Virus Designed to Enhance Delivery of New Generation of Pharmaceutical Agents

Dutch scientists have effectively developed an artificial virus that may be used for the delivery of a new generation of pharmaceutical agents, consisting of large biomolecules, by packaging them in a natural manner and delivering them to diseased cells.   More...
10 Sep 2014

Mutation Reducing Fatty Acid-Binding Protein Activity Lowers Heart Attack Risk

A team of Finnish cardiovascular disease researchers found that a mutation generating a low-expression variant of fatty acid-binding protein 4, reduced the risk of heart attack and stroke.    More...
08 Sep 2014

New ELISA Kit Measures Drug-Induced DNA Breaks

A gamma H2AX pharmacodynamic assay kit for the study of double strand DNA breaks through the detection of the phosphorylated histone, gamma-H2AX, is now available for drug developers as well as biotech and other life science researchers.  More...
07 Sep 2014

Naphthalene-Dipeptide Hydrogels Destroy Antibiotic-Resistant Bacterial Biofilms

Novel hydrogels derived from self-assembling dipeptides conjugated to naphthalene were shown to dissolve bacterial biofilms, which indicated considerable promise for use in constructing bacteria-resistant nanomaterial structures, biomaterials, and drug delivery devices.  More...
03 Sep 2014
Image: (Left) Neurons in brains from people with autism do not undergo normal pruning during childhood and adolescence. The images show representative neurons from unaffected brains (left) and brains from autistic patients (right); the spines on the neurons indicate the location of synapses (Photo courtesy of Guomei Tang, PhD and Mark S. Sonders, PhD, Columbia University Medical Center).

Autistic Youngsters Found to Have Too Many Brain Synapses

Autistic children and adolescents have been shown to have an excess of brain synapses, and this is due to a slowdown in the normal brain “trimming” process during development, according to new findings.   More...
02 Sep 2014
WATERS CORPORATION
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions.  More...
26 Aug 2014

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice.  More...
25 Aug 2014


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 

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