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12 Nov 2016 - 16 Nov 2016
16 Nov 2016 - 19 Nov 2016

Drug Discovery

Adenoid Cystic Carcinoma Stem Cells Depend on NOTCH1 and SOX10 Signaling

Cancer researchers have isolated a stem cell population from the cells making up an adenoid cystic carcinoma (ACC) tumor and showed that the signaling factors NOTCH1 and SOX10 were essential for the cancer stem cells to proliferate and resist radiation treatment. More...
05 May 2016

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. More...
04 May 2016
Image: A confocal microscopy image of stem cells loaded with drug containing polymeric microparticles (Photo courtesy of Jeff Karp and Oren Levy, Brigham and Women\'s Hospital).

Cells Loaded with Prodrug-Containing Microparticles Selectively Destroy Prostate Cancer Tumors

A novel approach to treating metastatic prostate cancer with minimal adverse side effects is based on cellular transport of a harmless prodrug that is activated and becomes toxic only in the vicinity of the tumor microenvironment. More...
02 May 2016

X-ray Crystallography Study May Lead to New Drugs to Block Cancer Metastasis

Cancer researchers expect that the structure of the enzyme P-Rex1 (PIP3-dependent Rac exchanger 1), which was recently established by X-ray crystallography, will lead to development of a new generation of cancer chemotherapeutic agents to block the processes leading to metastasis. More...
28 Apr 2016
Image: Altered caudal fin morphology following paclitaxel injection into larval zebrafish at 2 dpf. (A) Morphological changes (arrows) in the fin fold 1 hour after injection with 10 µM paclitaxel (insets show higher magnification). (B) Fin damage (arrows) 3 hour after paclitaxel injection. (C) Vehicle controls with undamaged fins 4 hour postinjection. (Scale bar, 200 µm.) hpinj = hours postinjection. (Image courtesy of Lisse TS et al, 2016, PNAS.)

Study Identifies Mechanism Underlying a Form of Sensory Nerve Damage

Researchers have discovered a mechanism that underlies induction of peripheral neuropathy (PN) by the chemotherapeutic agent paclitaxel, raising the prospects for developing treatments for this and possibly also for certain other forms of PN. The work may also lead to companion diagnostics to identify patients who would benefit from these new therapies. More...
27 Apr 2016

Genomics Makeup of Colorectal Tumors Predicts Immune Response

A study based on whole-exome sequencing and immune response finds that colorectal cancers (CRCs) heavily bedecked with tumor-related neoantigens are likely to be permeated with disease-fighting white blood cells (WBCs). The discovery helps sharpen research into therapies that make tumors more vulnerable to such an attack and into companion diagnostics. More...
27 Apr 2016
Image: A micrograph of eosinophilic esophagitis (EoE), H&E stain. Characteristic features are present: Abundant eosinophils—criteria vary; one common definition is: > 20 eosinophils/0.24 mm2; Papillae are elongated; papillae reach into the top 1/3 of the epithelial layer; Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness; Spongiosis (Photo courtesy of Wikimedia).

Pathway Implicated in Development of Eosinophilic Esophagitis

Scientists have identified a protein whose dysfunction appears to be involved in causing the tissue damage in patients with eosinophilic esophagitis (EoE). The finding may lead to improved pathology analysis, diagnostics, and specific drug therapies for patients. More...
26 Apr 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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