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Drug Discovery

Unraveling the Molecular Interactions That Enable Nutlin-Class Drugs to Kill Cancer Cells

Loss of the PUMA gene has been shown to protect tumor cells from being killed by the Nutlin class of experimental anticancer drugs.  More...
01 Mar 2016

Novel Nanoparticle Drugs Suppress Wide Range of Autoimmune Conditions

A novel class of drugs comprising nanoparticles coated with disease relevant peptide-major histocompatibility complexes coverts pathogenic T-lymphocytes into disease-specific regulatory T-cells, which suppress all other lymphocytes participating in the autoimmune disease process without compromising systemic immunity.  More...
28 Feb 2016

Antioxidant in Green Tea Reverses Arthritis Symptoms in Rat Model

The green tea compound epigallocatechin-3-gallate was shown to effectively reverse the symptoms of adjuvant-induced arthritis in a rat model, which mimics human rheumatoid arthritis.  More...
28 Feb 2016

LDL-DHA Nanoparticles Selectively Eradicate Liver Tumors in Rat Model System

Uptake of low-density lipoprotein particles loaded with the omega-3 fatty acid docosahexaenoic acid by liver cancer cells resulted in destruction of established tumors in a rat liver cancer model.  More...
22 Feb 2016

Molecular Signals from Neighboring Dendritic Cells Drive Leukemia Growth

Noncancerous cells in the immediate tumor microenvironment supply signals that drive T-cell acute lymphoblastic leukemia growth, and may become attractive therapeutic targets to control the disease.   More...
22 Feb 2016
Image: A neem tree – Azadirachta indica (Photo courtesy of Wikimedia Commons).

Neem Tree Extract Halts Pancreatic Cancer Growth in Mouse Models

Nimbolide, a compound extracted from the leaves of the neem tree  - Azadirachta indica, was shown in culture and mouse models to have potential as a chemotherapeutic agent for the treatment of pancreatic cancer.  More...
21 Feb 2016

Reducing NF-KappaB Signaling Ameliorates Neurological Symptoms in Rett Syndrome Mouse Model

By tracing the molecular pathway linked to the neurological disorder Rett syndrome, researchers have identified molecular pathway that seems to be a potential drug target for alleviating symptoms of the condition.  More...
21 Feb 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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