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Events

11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017
New products on world’s medical product marketplace:

Drug Discovery

Image: Positive alpha-synuclein staining of a Lewy body from a patient with Parkinson\'s disease (Photo courtesy of Wikimedia Commons).

Bifunctional Dimer Drugs Prove Effective in Parkinson's Disease Yeast Model

A team of Canadian neurodegenerative disease researchers used a yeast model system to identify novel drug compounds that were able to block the misfolding of alpha- synuclein (AS) protein, which characterizes the neurons of patients with Parkinson's disease. More...
11 Oct 2016
Image: As IBD worsens, levels of the gene regulator EZH2 increase, lowering numbers of protective Paneth cells (Photo courtesy of Sanford Burnham Prebys Medical Discovery Institute).

Maintaining Normal Paneth Cell Levels Prevents Intestinal Bowel Disease

The enzyme PKC-lamda/iota (protein kinase C-lamda/iota) plays a critical role in the intestinal epithelium where it influences development of inflammatory diseases and cancer through its regulation of Paneth cell metabolism. More...
06 Oct 2016
Image: A histopathological image of cerebral glioblastoma with Hematoxylin and esoin stain (Photo courtesy of Wikimedia Commons).

Blocking Pair of Metalloproteases Halts Brain Tumor Growth

A team of British cancer researchers has identified the metalloprotease enzymes ADAM10 and ADAM17 as potential therapeutic targets for the treatment of glioblastoma multiforme (GBM) brain tumors. More...
05 Oct 2016
Image: Chronic urinary tract infections caused by E. coli in mice were cured by vaccination that prevented a key binding protein from attaching to the bladder (Photo courtesy of Scott Hultgren and John Heuser, Washington University School of Medicine).

Potential Vaccine Prevents Chronic Urinary Tract Infections

A team of molecular microbiologists has developed a potential vaccine to prevent acute Escherichia coli urinary tract infections (UTIs) from becoming chronic. More...
04 Oct 2016
Image: A model of the crystal structure of adenosine deaminase, one of the protein targets of DMF. The amino acid labeled by DMF is shown in pink, and neighboring residues associated with a human immunodeficiency are shown in yellow (Photo courtesy of The Scripps Research Institute).

Binding of Cysteine Residues Reduces Severity of Multiple Sclerosis

A recent paper explained the mode of action of dimethyl fumarate (DMF), the most effective drug currently in use for the treatment of multiple sclerosis (MS). More...
04 Oct 2016
Image: The structure of the VCP protein (Photo courtesy of Wikimedia Commons).

Protein Linked to Destruction of Mitochondria in Huntington's Disease

Researchers studying the molecular mechanisms involved in Huntington's disease (HD) have identified a protein that binds to mutant huntingtin protein in the mitochondria of neurons, which results in destruction of the mitochondria and death of the nerve cells. More...
28 Sep 2016
Image: The structure of the SET protein (Photo courtesy of Wikimedia Commons).

Reactivation of p53 Shrinks Tumors in Mouse Model

Blocking a protein that inhibits lysine acetylation reversed the inactivation of the p53 protein and resulted in shrinkage of tumors in a mouse xenograft model. More...
27 Sep 2016

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The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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