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Micromedic Technologies

Drug Discovery

Ready Source of Functional Liver Cells Should Boost Drug Development Efforts

Liver function in newborns kicks in only after exposure to certain nutrient factors derived from gut bacteria, and this phenomenon has been used to differentiate pluripotent stem cells into fully functional liver cells.   More...
09 Aug 2015

Modifying the Macrophage Microenvironment Reduces Tuberculosis Virulence

The virulence of the bacteria causing latent tuberculosis infections can be reduced by modifying the microenvironment inside the macrophages that host the pathogen.  More...
05 Aug 2015

Chimeric Drug Reduces Local Inflammation Without Causing General Immune Suppression

A novel anti-inflammatory drug is based on a chimeric molecule that avoids general immune suppression by being non-active when injected but is converted into an activate agent by leukocytes concentrated at the site of local inflammation.  More...
02 Aug 2015
Image: A new micelle delivery system for the protective polyphenols resveratrol and quercetin (mRQ) may have value in cancer chemotherapy (Photo courtesy of Oregon State University).

Micelles Containing Resveratrol and Quercetin Reverse Doxorubicin Cardiotoxicity

Cancer researchers blocked the toxic effects of the cancer drug doxorubicin by administering it together with the plant antioxidants resveratrol and quercetin.  More...
28 Jul 2015

Advanced Genetic Tools Revamp Search for Drugs to Treat Cryptosporidium

Genetically engineered modifications to genome of the diarrhea-causing parasite Cryptosporidium are expected to expedite research towards vaccine and drug development to prevent or cure infection by this pathogen.  More...
28 Jul 2015
Image: The microneedle patch can dissolve in the skin, delivering the flu vaccine painlessly (Photo courtesy of Dr. Shinsaku Nakagawa, Osaka University).

Japanese Researchers Demonstrate Novel Transcutaneous Influenza Vaccination Using a Dissolving Microneedle Patch

Vaccination via a biodegradable microneedle patch was shown to generate immune response to various strains of the influenza virus that were equal to or stronger than those induced by traditional hypodermic needle injection.  More...
27 Jul 2015

Nanoparticle-Delivered siRNA Shrinks Tumors in Mouse Model

Cancer researchers employed a nanoparticle delivery system to deliver short interfering RNA that blocked the activity of Twist-related protein 1, which prevented growth and spread of tumors in a mouse model.  More...
20 Jul 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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