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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Drug Discovery

Image: Researchers have discovered that the drug pioglitazone, used to treat diabetes, shows some ability to halt the overexpression of the protein NAF-1, which has been associated with the proliferation of breast cancer (Photo courtesy of Fang Bai, Rice University).

Stabilizing Iron-Sulfur Transport Clusters Reduces Size and Aggressiveness of Tumors

An international team of cancer researchers has identified a protein that, when overexpressed, enabled breast tumors to better withstand oxidative stress thereby becoming much larger and more aggressive. More...
21 Sep 2016
Image: Ginger is the source of a novel class of nanolipid transport vector (Photo courtesy of Georgia State University).

Ginger-Derived Doxorubicin-Loaded Nanovectors as Drug Delivery for Cancer Therapy

A novel type of nanoparticle drug transport system based on lipids isolated from ginger was used to deliver the toxic chemotherapeutic agent doxorubicin (Dox) to colon cancer cells with minimal damage to normal tissues. More...
20 Sep 2016
Image: The structural model of the of the DRD2 protein (Photo courtesy of Wikimedia Commons).

Blocking Activity of Dopamine Receptor Impedes Growth and Spread of Pancreatic Cancer

Cancer researchers have found that a receptor protein that binds natural compounds such as dopamine and extraneous factors such as antipsychotic drugs to brain cells could inhibit the growth of pancreatic cancer and prevent it from metastasizing. More...
20 Sep 2016
Image: Researchers in Greece found the hormone irisin may help improve decrease diagnosis of PCOS in teenagers, and may prove to be an effective target for treatment (Photo courtesy of Alexander Raths / Shutterstock).

Hormone Test May Reduce Rate of Teens Misdiagnosed with PCOS

Measuring blood levels of the recently discovered hormone irisin may improve accurate diagnosis rates of teenagers with polycystic ovary syndrome (PCOS) and so reduce the number of unnecessary treatments prescribed to healthy girls at an especially critical stage in their lives. More...
19 Sep 2016
Image: Micrograph showing immunostained amyloid beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) (Photo courtesy of Wikimedia Commons).

Novel Human Monoclonal Antibody Shows Promise for Treating Alzheimer's Disease

A human monoclonal antibody that targets aggregated forms of amyloid-beta (Abeta) protein was shown in a phase Ib clinical study to reduce amyloid plaques in patients with early Alzheimer's disease and to slow or prevent cognitive decline in these individuals. More...
12 Sep 2016
Image: Surface model of Leishmania’s ribosomal large subunit (rLSU) based on the first high-resolution structure, obtained by 2.8-A° cryo-EM. Circled are the locations of three focal points of rLSU rRNA segmentation in regards to the ribosome exit tunnel. 26S rRNA segment-terminals in the leishmanial ribosome were found to converge to these three separate focal points, all located on the solvent-exposed side of the rLSU. The 5.8S rRNA chain is represented as yellow surface and all other chains are represented as cartoon tubes. The study revealed the fragmented nature of leishmanial rRNA and irregular distribution of rRNA modifications, with implications for drug development against Leishmania and related parasites (Photo courtesy of Cell Reports).

High-Resolution Analysis of Leishmanial Ribosome Provides Clues for Drug Design

Derived from a 2.8-Å cryo-EM map, researchers have achieved an atomic resolution structure of the Leishmania donovani large ribosomal subunit (rLSU). Comparison with other eukaryotes and with bacteria provides an important framework for better understanding ribosome biogenesis and a solid structural basis for developing highly selective therapeutics against Leishmania and closely related parasites. More...
08 Sep 2016
Image: A scanning electron micrograph (SEM) showing Salmonella enterica serotype Typhimurium (red) infecting human cells (yellow) (Photo courtesy of the [U.S.] NIAID Biodefense Image Library).

Salmonella-Based Nanoparticles Suppress Growth of Multidrug Resistant Tumors

Gold nanoparticles were used to transport the Salmonella enterica serotype Typhimurium protein SipA into cancer cells where it decreased the amount of the P-glycoprotein multidrug resistance transporter and suppressed tumor growth. More...
06 Sep 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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