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10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Drug Discovery

Image: MRI renderings of mouse brain tumors. Tumors treated with SKOG102 (lower panels) shrank by about half compared to tumors treated with a control (upper panels) (Photo courtesy of the University of California, San Diego).

Transcription Factor Inhibitors Block Growth of Lethal Brain Tumor

A new approach for treating the deadly brain tumor glioblastoma multiforme is based on small molecule inhibitors of the major class of protein signaling molecules known as transcription factors, which are essential for tumor survival and growth.  More...
10 Nov 2015

Nanoparticle Targeting May Revolutionize Cardiac Photoablation Therapy

A light-based therapeutic approach to correct cardiac arrhythmia has been improved by the development of a nanotechnique that allows precise delivery of photosensitive molecules to malfunctioning cardiomyocytes while avoiding normal cells.   More...
09 Nov 2015
Image: Structure of the ferritin complex. The toxic anticancer drug daunorubicin was sequestered at the core of the molecule, protected by the protein coat (Photo courtesy of Wikimedia Commons).

Apoferritin-Based Nanocapsules Used to Transport Toxic Anticancer Drug

A toxic anticancer therapeutic agent was encapsulated in capsules derived from apoferritin, which sequestered the drug until its selective delivery to cancer cells.  More...
08 Nov 2015
Image: Neutrophils produce bacteria-ensnaring NETs (shown in blue/green) in response to tamoxifen treatment (Photo courtesy of the University of California, San Diego).

Neutrophil Activation Underlies Cancer Drug's Antibacterial Effect

The bactericidal properties of the cancer drug tamoxifen have been linked to its modulation of sphingolipid biosynthesis and the effect this has on neutrophil activation and the generation of antimicrobial neutrophil extracellular traps.  More...
28 Oct 2015

Agreement Enlarges China's Role in Cancer Immunotherapeutics Development

A recent agreement marks the expansion of drug development collaboration between a Chinese biopharmaceutical company and a major international drug corporation.   More...
26 Oct 2015
Image: A liposome, stabilized by anchoring its membrane to a solid cord with polymeric tethers, could provide a more stable carrier for nanoparticles (Photo courtesy of ACS Nano: http://pubs.acs.org/doi/10.1021/acsnano.5b03439)

Computer Simulations for Improved Liposome Design

The extensive use of computer simulations has enabled researchers to design an improved class of liposomes for use in targeted delivery of toxic chemotherapeutic agents.  More...
25 Oct 2015
Image: Phase and T immunofluorescence images of mesoendoderm patterns in different drug test groups on day 3. The morphology of the mesoendoderm pattern was significantly disrupted under teratogen (Thalidomide, RA, D-penicillamine, or VPA) treatment in a dose-dependent manner; whereas under non-teratogen (Penicillin G) treatment, the structure of the mesoendoderm pattern remained unchanged. Scale bar = 200 μm (Photo courtesy of Xing J et al. 2015 and Institute of Bioengineering and Nanotechnology, Singapore).

Embryonic Development “In a Dish” – Recreating Two Key Processes

In a biotechnological advancement involving human pluripotent stem cells and geometric restriction, researchers have for the first time developed animal-free platforms to help screen for and study drugs that cause birth defects.  More...
21 Oct 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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