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Drug Discovery

Image: The glowing yellow specks in the image show uptake of the nanosponge vaccine by a mouse immune system dendritic cell. The detained alpha-hemolysin toxins were labeled with a fluorescent dye, which glows yellow. The cell membrane was stained red and the nuclei stained blue (Photo courtesy of the University of California, San Diego,  Department of NanoEngineering).

Novel Nanosponge Vaccine Protects Mice from MRSA Toxin

A novel vaccine based on "nanosponges" that sequester toxic, pore-forming toxoids permits presentation of these toxins to immune system defensive cells without danger of damaging them.  More...
10 Dec 2013
Image: Malaria parasites (labeled with fluorescent protein) in the late stages of development, superimposed on a field of red blood cells. The many nuclei of the parasites\' daughter cells are labeled in blue, and the plasma membranes surrounding the daughter cells are labeled in green. Imidazopyrazine treatment disrupts formation of the membranes around the daughter cells (Photo courtesy of Dr. Marcus C.S. Lee, Columbia University Medical Center).

Imidazopyrazines Kill the Malaria Parasite at Every Stage of Its Life Cycle

An enzyme that is vital to all life stages of several species of malaria parasites has been cited as a tempting target for drug developers.  More...
09 Dec 2013

Two Common Herbs Found to Improve Memory and Learning Capabilities

Enhanced extracts made from special antioxidants in spearmint and rosemary have been found to improve learning and memory, according to new lab research.  More...
04 Dec 2013

German Biopharmaceutical Partners to Seek Osteoarthritis Drug

Two German biopharmaceutical companies are joining forces to develop a new class of drugs for treatment of osteoarthritis.   More...
02 Dec 2013

Consortium to Develop MicroRNA-Based Drugs for Treatment of Head and Neck Cancer

A consortium of biotechnology companies and medical centers from The Netherlands, Germany, and Israel has been granted funding from the European Union’s FP7 program to develop a new class of highly selective targeted therapeutics for the treatment of head and neck cancer based on novel tumor-selective lethal micro RNAs.   More...
28 Nov 2013
Image: Electron micrograph of bacteriophages attached to a bacterial cell (Photo courtesy of Wikimedia Commons).

Bacteriophage Protein Shows Antibiotic Potential

The T7 bacteriophage produces a protein that blocks Escherichia coli cell division and has the potential of being developed into an antibiotic-replacing drug.  More...
27 Nov 2013

Blocking the MK2 Pathway Sensitizes Lung Cancer Cells to DNA-Damaging Chemotherapy

Cancers with mutations in the p53 gene can be rendered more sensitive to chemotherapy with DNA-damaging agents such as cisplatin by co-treatment with a drug that blocks the function of the MK2 gene.  More...
27 Nov 2013


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 
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