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Drug Discovery

Image: Schematic diagram of dendrimer structure (Photo courtesy of the University of California, Irvine).

Dendrimer-Transported MicroRNA Shown Effective in Treating Mice with Late-Stage Liver Cancer

Cancer researchers have used nanocarriers called dendrimers to transport a specific tumor growth-inhibiting microRNA to the livers of mice with late-stage liver cancer.  More...
10 Feb 2016
Image: Open fruit of the achiote tree (Bixa orellana), showing the seeds from which annatto is extracted (Photo courtesy of Wikimedia Commons).

Annatto Component Prevents UV Damage and Prevents Skin Cancer in Mouse Model

The apocarotenoid compound bixin is a widely consumed food additive that was shown in a recent paper to have potent antioxidant properties, which prevented the formation of cancer cells and skin damage from UV radiation in a mouse model.  More...
09 Feb 2016

Atomic Structures of Alternative Splicing Regulator Proteins May Lead to New Anticancer Drugs

A detailed structural analysis of two RNA-binding proteins that regulate alternate splicing of gene expression, which can lead to various types of cancer, is expected to aid in the development of drugs to suppress this activity.  More...
08 Feb 2016

Nanocarriers Deploy Enzymes for Targeted Delivery of Anticancer Drugs

A newly devised nanocarrier delivery system transports a combination of anticancer and anti-angiogenesis drugs to the site of a tumor where the acidic environment releases them to damage the cancer cells and deprive them of nutrients by blocking creation of new blood vessels.   More...
08 Feb 2016

First-Ever Gene Identified with Biological Origin of Schizophrenia

In a landmark study, researchers have identified mutants of the complement component 4 gene that are strongly associated with the risk of developing schizophrenia.   More...
07 Feb 2016
Image: Naturally occurring clay from Kisameet Bay, Canada, exhibits potent antibacterial activity against multidrug-resistant pathogens (Photo courtesy of Kisameet Glacial Clay Inc.).

Antibiotic Resistant Bacteria Succumb to Treatment with Unique Natural Clay

A team of Canadian medical microbiologists has demonstrated the potential use of a unique type of natural clay for treating pathogenic bacteria that have become resistant to the commonly used antibiotics.  More...
07 Feb 2016

Tag Team Combination Simplifies Vaccine Development

Vaccine development is simplified when a highly immunogenic virus-like particle carrier is tagged with a genetically-encoded protein designed to spontaneously form a covalent bond to its antigen-labeled peptide-partner.  More...
03 Feb 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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