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Drug Discovery

Verteporfin Blocks Growth of Deadly Eye Melanoma

Simultaneous mutations in two G-protein encoding genes that cause the overexpression of a carcinogenic protein have been linked to the development of uveal melanoma, a deadly cancer of the colored areas of the eye.  More...
08 Jun 2014

Smart Drug-Delivery Cage Designed to Fight Cancer

Chemists have developed a nano-scale cage of chemical bonds that entraps small molecule drugs and then infiltrates cancer cells, showing potential to act as a “smart” drug-delivery processes to fight cancer and other disorders.  More...
04 Jun 2014

Leelamine Blocks Melanoma Growth by Disrupting Cellular Cholesterol Transport

An experimental chemotherapeutic drug interferes with intracellular cholesterol transport, which kills melanoma cells by disrupting several molecular pathways simultaneously.  More...
03 Jun 2014

Novel Antisense Compound Reverses Alzheimer's Disease Symptoms in Mouse Models

An antisense oligonucleotide, which suppresses the mRNA required for synthesis of amyloid-beta protein precursor, decreased AbetaPP expression and amyloid-beta protein production, and reversed Alzheimer's disease symptoms in mouse models.  More...
02 Jun 2014

Metabolon Collaborates with GSK for Metabolomics Research Platform

Metabolon, a diagnostics and research services company offering metabolomics research platforms, has entered into a collaboration with GlaxoSmithKline to provide metabolomic profiling services and to collaborate on other research projects utilizing Metabolon’s DiscoveryHD4 platform.  More...
02 Jun 2014

RNAi Therapy Reduces Huntington's Disease Symptoms in Mouse Model

A research team used advanced gene therapy techniques to block the production of huntingtin, the toxic protein found in the brains of patients suffering from the fatal, inherited neurodegenerative disorder, Huntington's disease.   More...
01 Jun 2014

Stem Cells Loaded with Oncolytic Herpes Virus Destroy Brain Tumors in Mouse Model

Cancer researchers treated mouse models of the human brain tumor glioblastoma multiforme by injecting the animals with stem cells loaded with oncolytic herpes virus and treated virus-resistant tumors with oncolytic herpes viruses genetically engineered to express the proapoptotic cytokine TRAIL.  More...
26 May 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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