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Drug Discovery

Exosome Delivery Dramatically Boosts Anticancer Drug Potency

The use of exosome nanoparticles to transport the anticancer drug paclitaxel was shown to dramatically reduce the amount of drug required to kill lung cancer cells in culture and in a mouse model.  More...
25 Jan 2016

Key Finding May Lead to Improved Treatment of Aggressive Brain Cancers

Researchers have shown an essential role for the cell microenvironment in the growth of glioblastoma brain cancer cells, a discovery that could lead to a breakthrough in fighting such deadly cancers.  More...
20 Jan 2016

Blocking ERK Signaling Inhibits Growth of Some Pancreatic Cancer Cell Lines

A recent paper discussed the potential of a drug that suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines by blocking the ERK component of the RAF-MEK-ERK molecular pathway.  More...
19 Jan 2016

Deleting the Dicer DNA-Repair Enzyme Increases Sensitivity of Cancer Cells to Chemotherapy

Blocking the activity of the enzyme Dicer in rapidly growing cancer cells prevents them from correcting DNA damage, which renders them more sensitive to the action of chemotherapeutic drugs.  More...
12 Jan 2016

Cell-Free Bioreactor Produces Therapeutic Proteins for Point-of-Care Use

A microfluidic bioreactor for cell-free protein synthesis was developed to facilitate the production of a single-dose of a therapeutic protein for point-of-care delivery.  More...
11 Jan 2016

Interactive Cancer Drug Discovery Database Has Been Enlarged and Enhanced

An important interactive data base for cancer drug discovery has been updated and augmented by the addition of three-dimensional structures of mutated proteins and maps of cancer communication networks.  More...
10 Jan 2016

Proteasome-Activating Drug Reverses Neurodegenerative Disease Symptoms in Mouse Model

Accumulation of insoluble tau protein complexes, which characterizes several types of neurodegenerative diseases, was associated with a decrease in brain proteasome peptidase activity that could be restored by treatment with a phosphodiesterase-4 inhibitor drug.  More...
06 Jan 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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