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Drug Discovery

DNA-Constructed Nanoparticles Safely Target Tumors

A team of Canadian researchers has discovered a way to assemble “building blocks” of gold nanoparticles as the vehicle to deliver cancer medications or cancer-identifying markers directly into cancerous tumors.  More...
17 Feb 2014
Image: The Zucker diabetic fatty (ZDF) rat compared to a normal laboratory rat (Photo courtesy of medic, Japan).

Experimental Drug Reduces Brain Inflammation in Diabetic Rat Model

A recent paper reported that peptides that mimic the activity of thioredoxin were able to inhibit the development of inflammation in the brains of Zucker diabetic fatty rats.  More...
11 Feb 2014

Collaboration to Standardize Chemistry-Based Metabolism Prediction, Profiling Technology to Improve Drug Discovery Process

Empiriko, a clinical intelligence company, and CreaGen Biosciences, a drug discovery service company and science research incubator, have reached an agreement under which CreaGen will provide chemistry expertise and modern laboratory facilities for scaling and standardizing Empiriko’s chemosynthetic liver technology.  More...
10 Feb 2014
Image: A novel HDL nanoparticle (red) loaded with a statin drug, specifically targets and locally treats inflammatory macrophage cells (green) hiding inside high-risk plaque within blood vessels (Photo courtesy of Mount Sinai Medical Center).

Nanoparticle Therapy Reduces Plaque Inflammation and Lowers Risk of Heart Attack or Stroke

Reconstituted HDL nanoparticles were used to transport inflammation-retarding statins to atherosclerotic plaques where the drug acted to reduce arterial blockage that could cause heart attack or stroke.  More...
06 Feb 2014

Natural Fruit, Vegetable Compound Blocks Alzheimer’s Disease in Mice

A compound that is found in fruits and vegetables, from strawberries to cucumbers, has been shown to halt memory loss that accompanies Alzheimer’s disease in mice.  More...
04 Feb 2014

Asparagine Metabolism Empowers Group A Streptococcus Infection

The bacteria that cause the frightening syndrome called "flesh-eating disease" have been found to be stimulated by the amino acid asparagine and inhibited by the chemotherapeutic enzyme asparaginase, which destroys asparagine.  More...
30 Jan 2014

Gold Nanoparticles Designed to Track Viruses

Finish scientists have developed a unique strategy for the study of Enterovirus structures and their biologic processes.   More...
30 Jan 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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