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Drug Discovery

Image: Transmission electron micrograph of a cell mitochondrion (Photo courtesy of the University of California, San Diego).

Candidate Drug Kills Solid Tumors by Blocking Mitochondrial Respiration

Swedish researchers have developed a candidate low molecular weight drug that kills metabolically stressed cancer cells by interfering with the action of their mitochondria.  More...
03 Mar 2014

Researchers Describe Novel Methods for Disabling Bacterial Proteases

A paper described previously unrecognized mechanisms that can be used to permanently deactivate critical bacteriological proteases.  More...
27 Feb 2014
Image: The crystal structure of the small virus used to deliver antibodies as vectored immunoprophylaxis (VIP) against HIV (Photo courtesy of Alejandro Balazs, California Institute of Technology).

HIV-Fighting Vectored Immunoprophylaxis Antibody Delivery Technique shows Potential

In 2011, US biologists demonstrated a treatment that protected the mice from infection by a laboratory strain of HIV delivered intravenously. The same researchers have now shown that the procedure is just as effective against a strain of HIV found in the real world. More...
27 Feb 2014
Image: Microscopic image of gram-negative Pseudomonas aeruginosa bacteria (pink-red rods) (Photo courtesy of Wikimedia Commons).

European Drug Development Project Targets Gram-negative Bacteria

A consortium of European universities, research institutes, and biopharmaceutical companies has been established to discover and develop novel new antibiotics, especially for treatment of gram-negative bacterial infections.  More...
25 Feb 2014
Image: The mouse in the upper right is the mutant mdx/mdx and is shown with a normal control (Photo courtesy of the Jackson Laboratory).

Rapamycin Nanoparticles Correct Autophagy Defects in Mouse Muscular Dystrophy Model

Nanoparticles coated with rapamycin were found to improve strength and heart function in a mouse model for Duchenne muscular dystrophy.   More...
25 Feb 2014
Image: Grape seed extract may represent a new therapeutic option to alleviate damage caused by chemotherapy to intestinal tissues while reducing the viability of colon cancer cells (Photo courtesy of Nutritional Outlook).

Grape Seed Extract Increases Effectiveness of Chemotherapy While Alleviating Damaging Side Effects

Australian cancer researchers have shown that grape seed extract can alleviate some of the damage caused by chemotherapy for colon cancer while increasing the effectiveness of the treatment.  More...
25 Feb 2014

Top 10 US Biomedical Research Institutions Involved in Drug Development

As Big Pharma companies are increasingly slashing their R&D spending, academic research institutions must play a key role in the drug development process, particularly on the preclinical research and drug discovery side.   More...
23 Feb 2014


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 
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