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Drug Discovery

Nanoscale Velcro Proteins Discovered to Be Used for Molecule Transport

Scientists have discovered that proteins found within the nuclear pore function similar to a “Velcro” snap that can be used for controlled and selective transport of particles.   More...
01 Jul 2014

High GABA Level Astrocytes Are a New Alzheimer's Disease Biomarker and Drug Target

Cells comprising an abnormal class of brain cells called reactive astrocytes contain high levels of the inhibitory neurotransmitter gamma-aminobutyric acid and are being eyed by researchers as a potential biomarker and drug target for Alzheimer's disease.   More...
25 Jun 2014
Image: Transmission electron micrograph of a cell mitochondrion (Photo courtesy of Thomas Deerinck, NCMIR, UC San Diego).

Dose of 100-Year-Old Drug for Sleeping Sickness Reverses Autism-Like Symptoms in Lab Mice

By exploring a unique hypothesis that suggests autism is a result of faulty cell communication, researchers revealed that a nearly 100-year-old drug approved for treating sleeping sickness has been found to restore normal cellular signaling in a mouse model of autism.  More...
23 Jun 2014

Antisynuclein Monoclonal Antibody Reverses Parkinson's Disease Symptoms in Culture and Mouse Models

The development of Parkinson's disease in a mouse model was blocked by treatment with monoclonal antibodies directed at alpha-synuclein, the main protein component of the Lewy bodies and Lewy neurites that characterize the disease.  More...
23 Jun 2014
Image: Histopathologic image of small-cell lung cancer (Photo courtesy of Wikimedia Commons).

Mouse Explants Generated from Patients' Circulating Tumor Cells Pave Way for Directed Personalized Chemotherapy

Cancer researchers have isolated circulating tumor cells from patients with small-cell lung cancer and implanted them into immunocompromised mice to use as a model system for developing better treatments for the disease.  More...
19 Jun 2014

Genetic Techniques May Lead to New Therapeutic Approaches for Cardiovascular Diseases

A review summarized the state-of-the-art in the field of genome-based therapies for cardiovascular diseases.  More...
19 Jun 2014

Synthetic Peptide Non-Covalently Transports Cancer Drugs Across the Blood-Brain Barrier

Cancer researchers have used a novel synthetic peptide to transport chemotherapeutic compounds and other small molecules across the blood-brain barrier and into the brains of mice.  More...
18 Jun 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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