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Drug Discovery

Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease in a mouse model.  More...
13 Apr 2015

Drug Development Acquisition Focuses on Treatment for Movement Disorders

The purchase of a biomedical company that develops drugs for treatment of hyperkinetic movement disorders by one of the world's largest producers of generic drugs is expected to strengthen the generics manufacturer's position in the market for central nervous system condition treatments.  More...
12 Apr 2015
Image: Imaging of burn wounds in mice by confocal microscopy indicates that those treated with FL2 siRNA nanoparticles (far right) experienced collagen deposition and hair follicle formation (Photo courtesy of the Albert Einstein College of Medicine).

Small Interfering RNA Nanoparticles Accelerate Wound Healing in Mouse Model

The time required for wound healing in a mouse model was significantly shortened by treatment with nanoparticles that had been loaded with small interfering RNA that blocked the synthesis of the enzyme fidgetin-like 2.  More...
07 Apr 2015
Image: TEM (transmission electron micrograph) of a mesoporous silica nanoparticle (Photo courtesy of Wikimedia Commons).

Nanoparticle Delivery of Drug Combination Blocks Pancreatic Cancer Growth in Mouse Model

Cancer researchers using two potent chemotherapeutic agents combined in one nanoparticle demonstrated significant improvement in the treatment of pancreatic tumors in a mouse model.  More...
06 Apr 2015
Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening.  More...
22 Mar 2015

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead to cancer and other diseases.   More...
17 Mar 2015
Image: TEM (transmission electron micrograph) of a mesoporous silica nanoparticle (Photo courtesy of Wikimedia Commons).

Silica-Based Nanoparticles Selectively Kill Lung Cancer Cells

A novel approach to the selective delivery of toxic chemotherapeutic agents is based on nanoparticles that sequester the drug until it is liberated by the action of specific proteases that are present in a high concentration inside lung cancer cells.  More...
16 Mar 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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