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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Drug Discovery

Image: Antibacterial drugs cause changes in the intestinal flora. These changes have an influence on the capacity of the liver and kidneys to detoxify and eliminate therapeutic drugs due to large changes in the metabolizing and transport proteins (Photo courtesy of Dr. Sumio Ohtsuki, Kumamoto University).

Antibiotics-Induced Changes to Gut Bacteria Influence Expression of Drug Side Effects

Antibiotic treatment disrupts the normal bacterial population of the gut resulting in changes in how the body deals with the breakdown and transport of drugs and other metabolites, which may increase the impact of deleterious side effects. More...
23 Aug 2016
Image: A kidney stone (yellow) composed of calcium oxalate showing sharp edges (Photo courtesy of Wikimedia Commons).

Hydroxycitrate Potentially More Effective Than Citrate for Kidney Stones

The chemical hydroxycitrate (HCA) was shown in a recent study to be more effective for treating calcium oxalate kidney stones than the commonly used compound potassium citrate. More...
18 Aug 2016
Image: A molecular model showing the experimental antibody drug ZMapp binding to the Ebola virus, here targeting the virus\'s GP protein (Photo courtesy of Dr. Andrew Ward and Dr. Jesper Pallesen, Scripps Research Institute).

High-Resolution Cryo-EM Images Increase Understanding of Anti-Ebola Drug

High-resolution cryo-electron microscopy images have revealed more precise information as to how the experimental drug ZMapp binds to the Ebola virus and provide insights into how the drug prevents growth of the pathogen. More...
18 Aug 2016
Image: A transmission electron microgragh (TEM) of Deinococcus radiodurans (Photo courtesy of Dr. Michael Daly, Uniformed Services University of the Health Sciences).

Synthetic Antioxidant Peptide Protects Mice from Lethal Levels of Radiation

An antioxidant peptide compound that mimics those produced by the bacterium Deinococcus radiodurans was found to effectively protect cell cultures and mice exposed to lethal levels of gamma radiation. More...
18 Aug 2016
Image: Trypanosoma sp. parasites in blood smear from a patient with African trypanosomiasis (Photo courtesy of the CDC).

Experimental Drug May Be Universal Cure for Kinetoplastid-Based Diseases

An experimental drug that targets the kinetoplast proteasome found in several types of protozoan parasites shows potential for development into a universal treatment for these pathogenic microorganisms. More...
17 Aug 2016
Image: A photomicrograph (200X) showing McCoy cell monolayers with Chlamydia trachomatis inclusion bodies (Photo courtesy of the CDC).

Prototype Vaccine Protects Against Multiple Chlamydia Strains

A prototype vaccine to protect against Chlamydia trachomatis infection gave promising results when tested in vitro and in a mouse model system. More...
03 Aug 2016
Image: Multiple bacilli (rod-shaped bacteria, here shown as black and bean-shaped) shown between white blood cells in urinary microscopy. These changes are indicative of a urinary tract infection (Photo courtesy of Wikimedia Commons).

Bladder Cells Use Exocytosis to Fight Urinary Tract Infections

A team of molecular microbiologists has identified a method used by the cells lining the bladder to protect themselves against urinary tract pathogens by packaging bacteria into vesicles that are expelled from the cytoplasm. More...
02 Aug 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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