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Drug Discovery

Image: A novel HDL nanoparticle (red) loaded with a statin drug, specifically targets and locally treats inflammatory macrophage cells (green) hiding inside high-risk plaque within blood vessels (Photo courtesy of Mount Sinai Medical Center).

Nanoparticle Therapy Reduces Plaque Inflammation and Lowers Risk of Heart Attack or Stroke

Reconstituted HDL nanoparticles were used to transport inflammation-retarding statins to atherosclerotic plaques where the drug acted to reduce arterial blockage that could cause heart attack or stroke.  More...
06 Feb 2014

Natural Fruit, Vegetable Compound Blocks Alzheimer’s Disease in Mice

A compound that is found in fruits and vegetables, from strawberries to cucumbers, has been shown to halt memory loss that accompanies Alzheimer’s disease in mice.  More...
04 Feb 2014

Asparagine Metabolism Empowers Group A Streptococcus Infection

The bacteria that cause the frightening syndrome called "flesh-eating disease" have been found to be stimulated by the amino acid asparagine and inhibited by the chemotherapeutic enzyme asparaginase, which destroys asparagine.  More...
30 Jan 2014

Gold Nanoparticles Designed to Track Viruses

Finish scientists have developed a unique strategy for the study of Enterovirus structures and their biologic processes.   More...
30 Jan 2014
Image: Micrograph of KSHV-induced tumor showing abundant small branching blood vessels and spindle cells (Photo courtesy of Wikimedia Commons).

Experimental Drug Blocks Growth of Virus-Induced Cancer

An experimental drug that selectively targets the enzyme sphingosine kinase blocked the growth of primary effusion lymphoma, a deadly tumor linked to the Kaposi's sarcoma-associated herpesvirus that frequently occurs in those infected with HIV.   More...
29 Jan 2014
Image: According to a new study, the ability of Tianqi, a Chinese herbal medicine, to reduce the risk of developing diabetes, is similar to that of diabetes drugs, metformin and acarbose (Photo courtesy of the University of Chicago).

Traditional Chinese Herbs Found to Suppress Progression of Diabetes

Traditional Chinese herbal medicines have the potential for slowing the progression from prediabetes to a clinical diabetes diagnosis, according to new research.  More...
28 Jan 2014
Image: The structure of the nanoparticle (left) and how the nanoparticles home in on a tumor and shrink it (right) (Photo courtesy of North Carolina State University).

Nanoparticle Co-Delivery of a Membrane-Associated Protein and a Small-Molecule Anticancer Drug Enhanced Therapeutic Efficacy in a Mouse Model

Combining two anticancer drugs within a novel targeted nanoparticle overcomes their shortcomings and forms the basis for a new therapeutic agent with improved inhibition of tumor growth in a mouse xenograft- tumor model.   More...
23 Jan 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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