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Drug Discovery

Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome. More...
22 Jul 2014

Bacterial Populations Rapidly Evolve a Time-linked Tolerance to Antibiotics

A team of molecular microbiologists has found that some types of bacteria develop tolerance towards antibiotic treatment by "learning" how to time the length of exposure to the drug and evolving an extended period of dormancy that protects the organisms from the effects of the antibiotic.   More...
14 Jul 2014
SLAS - Society for Laboratory Automation and Screening
Image: A mouse mammary gland missing the tumor-suppressor p53 shows expression of ARF (green), now known for a backup role in protecting cells from becoming cancerous. If both p53 and ARF are mutated, the tumors that form are aggressive and may benefit from treatment with anti-inflammatory drugs called JAK inhibitors, currently prescribed for rheumatoid arthritis (Photo courtesy of Raleigh Kladney).

Anti-Inflammatory Drugs May Treat Some Aggressive Tumors

New research raises the possibility that some cancer patients with aggressive tumors may benefit from a class of anti-inflammatory drugs used to treat rheumatoid arthritis.  More...
10 Jul 2014

Polyphenol-Rich Cocoa Extracts Protect Against Alzheimer's Disease

A recent paper suggested that flavonol-rich cocoa extracts interfere with the processes that lead to the development of Alzheimer's disease.  More...
08 Jul 2014

Diabetes Linked to Faulty Mitochondria Disposal Pathway

A molecular pathway that regulates the disposal of defective mitochondria has been cited as a potential target for prevention and control of diabetes and certain other diseases.  More...
08 Jul 2014

Cholesterol Inhibitor Blocks Breast Cancer Growth in Mouse Model

A low molecular weight drug that inhibits cholesterol biosynthesis was found to block the growth of breast tumors by modifying the ratio of proliferative and antiproliferative estrogen receptors.   More...
02 Jul 2014

Nanoscale Velcro Proteins Discovered to Be Used for Molecule Transport

Scientists have discovered that proteins found within the nuclear pore function similar to a “Velcro” snap that can be used for controlled and selective transport of particles.   More...
01 Jul 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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