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Drug Discovery

Image: DNA polymerase forms a homodimeric ring (shown as blue cartoon and surface representation). Each polypeptide chain binds one molecule of griselimycin (red). The optimized compound cyclohexylgriselimycin contains an additional cyclohexane moiety (yellow, shown only for the ligand in the foreground) (Photo courtesy of the Helmholtz Centre for Infection Research).

New Version of Old Drug Shows Promise for Treating Drug-Resistant Tuberculosis

A team of molecular microbiologists has determined the mechanism by which theStreptomyces-derived antibiotic griselimycin blocks the growth of Mycobacterium tuberculosis, the bacterium responsible for causing more than eight million cases of tuberculosis annually on a worldwide basis.  More...
15 Jun 2015

Mouse Model Demonstrates Importance of Interleukin-6 to Spread of Prostate Cancer

Cancer researchers used a recently developed mouse model of metastatic prostate cancer to determine what factors are involved in the processes that trigger cell proliferation and drive progression of the disease.  More...
14 Jun 2015
Image: In rheumatoid arthritis, fibroblast-like synoviocytes—specialized cells that line the inside of joints—invade and destroy the affected joint\'s cartilage. Ezrin, which plays in important role in cell adhesion and migration, is shown in green, actin in red, and the cells\' nuclei in blue (Photo courtesy of Dr. Karen Doody and Dr. Bill Kiosses, La Jolla Institute of Allergy and Immunology).

Treating New Rheumatoid Arthritis Drug Target Would Not Increase Immune Suppression

Treatment directed at a newly identified drug target in rheumatoid arthritis would prevent damage to the joints while not increasing the immune suppression that is induced by the action of currently used therapies.  More...
03 Jun 2015
Image: Structure of the DDX3X protein (Photo courtesy of Wikimedia Commons).

Experimental Drug Blocks Critical Lung Cancer DNA Repair Enzyme

A low molecular weight drug—effective on its own and in combination with radiation therapy—has been developed that interferes specifically with the cell cycle of lung cancer cells.  More...
02 Jun 2015
Image: Micrograph shows marrow-infiltrating lymphocytes in cell culture (Photo courtesy of Dr. Kimberly Noonan, Johns Hopkins University).

Preliminary Clinical Trial Demonstrates Feasibility of Treating Multiple Myeloma with the Patient's Own Marrow-Infiltrating Lymphocytes

Results of a small clinical trial support the feasibility of using a multiple myeloma patient's marrow-infiltrating lymphocytes as the basis for adoptive T cell therapy.  More...
01 Jun 2015

Target Molecule for Treatment of Multiple Sclerosis Identified

A protein marker expressed by a subset of human lymphocytes, which is capable of crossing the blood brain barrier and causing inflammation and damage to the neural tissues of individuals with multiple sclerosis, has been singled out as a potential drug target for treatment of the disease.  More...
01 Jun 2015

Oxidized LDL Predicts Response to Interferon Treatment of Chronic Hepatitis C and May Be a Treatment Option

Oxidized low-density lipoprotein in the blood was shown to predict responsiveness to interferon treatment in patients with chronic Hepatitis C virus infection and to inhibit spread of the virus in vitro.  More...
27 May 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
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