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Drug Discovery

Rare Type of Soft-Tissue Cancer May Be Cured by Suppressing Tumor Growth Protein

A rare, lethal type of soft-tissue sarcoma may be entirely eradicated merely by suppressing a key protein involved in its growth.  More...
13 Jan 2014

Schizophrenia Linked to Defects in the Brain's Autophagy Pathway

A recent paper has linked schizophrenia to inhibition of the cellular degradative process autophagy in the hippocampus segment of the brain.  More...
09 Jan 2014
Image: Trypanosoma cruzi in blood smear from patient with trypanosomiasis (Photo courtesy of the CDC – [US] Centers for Disease Control and Prevention).

Cruzipain Inhibitors Show Potential for Treatment of Chagas Disease

A new generation of antiparasitic drugs based on inhibitors of the enzyme cruzipain has been shown to have potential for more effective treatment of the chronic form of Chagas disease.  More...
08 Jan 2014
Image: Blood smear from a P. falciparum culture. Several red blood cells show ring stages inside them, while close to the center there is a schizont and on the left a trophozoite (Photo courtesy of Wikimedia Commons).

New Generation of Malaria Drugs Block Myristoylation in the Parasite

Researchers have identified the enzyme N-myristoyltransferase as a target for a new generation of drugs to be used for the treatment of malaria.  More...
02 Jan 2014
Image: As proof of the power of their new screening strategy, researchers at The Scripps Research Institute used the method to identify a compound that shows promise for treating obesity-linked diabetes. This image shows a structure identified as a target for obesity-diabetes (human Ces3), superimposed on a field of human fat cells with their lipids stained with a fluorescent dye (Photo courtesy of the Scripps Research Institute).

Combination Drug Screening Strategy Identifies Obesity-Diabetes Treatment Target

A drug discovery strategy that combined phenotypic screening with a target-identification approach was used to identify a novel drug target that, when treated, relieved symptoms of metabolic disease in mouse models.  More...
02 Jan 2014
Image: Phase contrast showing location of whole cells (Photo courtesy of Prof. C.L. Jaffe, Hebrew University, and of PLOS One).

Unique Kinase Found Important for Parasite Survival and Virulence

A unique protein kinase secreted by the human parasite Leishmania was found to be important for the parasite's growth and virulence, making it a potential new chemotherapeutic target against leishmaniasis.  More...
01 Jan 2014

European Partners to Seek New Approaches for Dealing with Colorectal Cancer

A European research project is directed at finding new diagnostic and therapeutic tools to better find and treat patients with colorectal cancer.  More...
26 Dec 2013

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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