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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Drug Discovery

Image: Photomicrographs of fibroblasts from patients with Huntington\'s disease marked with fluorescence. Top row: the cells have accumulated mutant RNA. Bottom row: the cells no longer show blocked RNA accumulations (Photo courtesy of the Center for Genomic Regulation).

Blocking Mutant RNA Cures Huntington's Disease in Mouse Model

Researchers seeking ways to treat Huntington's disease have suggested going after the messenger RNA that mediates between the mutant gene that causes the disease and the toxic protein that causes the neurological damage that characterizes it. More...
23 Nov 2016
Image: A micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons).

Mitochondrial Protein Linked to Development of Prostate Cancer

Results obtained from experiments with genetically engineered mouse models revealed a direct link between the mitochondrial chaperone protein, TRAP1 (TNF receptor associated protein 1) and the development of prostate cancer. More...
23 Nov 2016
Image: A digitally colorized transmission electron micrograph (TEM) of Zika virus. Virus particles, here colored red, are 40 nanometers in diameter, with an outer envelope, and an inner dense core (Photo courtesy of the CDC).

DNA-based Zika Vaccine Demonstrates Potential in Animal Models

A DNA-based vaccine has shown promise in protecting animal models against infection and brain damage caused by the Zika virus. More...
22 Nov 2016
Image: The NS1 monobody binds to H-RAS or K-RAS protein and blocks RAS function by disrupting the protein\'s ability to form active molecular pairs (Photo courtesy of Dr. John P. O\'Bryan, University of Chicago).

Experimental Monobody Drug Inhibits Most Mutated RAS Oncogenes

A novel monobody drug candidate was found to effectively block the action of most of the RAS family of proto-oncogenes, which are mutated in nearly 90% of pancreatic cancers and are also highly prevalent in colon cancer, lung cancer, and melanoma. More...
17 Nov 2016
Image: Huntingtin aggregates (brown) are elevated in skin sections from HD model mice (left). Levels are reduced after treatment with P110 (right) (Photo courtesy of Disatnik).

Biomarkers Demonstrate Potential as Indicators of HD Progression

Several peripheral biomarkers have been identified that demonstrate the potential to serve as indicators to assess progression of Huntington’s disease. More...
17 Nov 2016
Image: A researcher holds a tray of Zika virus growing in animal cells. Researchers have identified a human antibody that prevents, in pregnant mice, the fetus from becoming infected and the placenta from being damaged (Photo courtesy of Huy Mach, Washington University School of Medicine).

Human Monoclonal Antibodies Prevent Congenital Transfer of Zika Virus in Mice

A class of human monoclonal antibodies specific for Zika virus was found to prevent transfer of the virus from pregnant mice to the fetus as well as protecting adult mice from infection. More...
16 Nov 2016
Image: When the mouse gene Rabep2 is deficient, the number and diameter of collateral blood vessels are reduced by 50-60%, and the amount of brain tissue that dies after stroke is more than doubled. The human version of Rabep2 is likely to have a comparable function (Image courtesy of the Faber Lab, University of North Carolina School of Medicine).

Vascular Development Gene Helps Protect Against Stroke Damage

Using CRISPR gene-editing technology and genetically engineered mice, scientists have discovered that a “collateral vessels” gene, Rabep2, protects against stroke damage. Variants of the human version of the gene may help explain why people differ so much in their ability to survive artery blockages. More...
15 Nov 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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