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Drug Discovery

Low-Calorie Cranberry Juice Shown to Lower Cardiovascular Disease Risk

Supplementing the diet with low-calorie cranberry juice reduces the chances of developing cardiovascular disease by lowering several risk factors including circulating triglycerides, C-reactive protein, glucose, and diastolic blood pressure.  More...
14 Jul 2015

Relieving Endoplasmic Reticulum Stress May Prevent Some Types of Chronic Disease

A team of cell biologists has identified an enzyme that protects cells against endoplasmic reticulum stress and prevents the apoptosis that characterizes such chronic diseases as Wolfram syndrome, diabetes, heart disease, and Parkinson's disease.  More...
08 Jul 2015
Image: Scanning electron microscope (SEM) image of a field of polypyrrole nanowires (Photo courtesy of Dr. Richard Borgens, Purdue University).

Novel Controlled-Release Drug Delivery System Heals Spinal Inflammation in Mouse Model

A novel drug delivery system that allows controllable release of an anti-inflammatory agent directly to the site of inflammation or injury was tested successfully in a mouse model.  More...
06 Jul 2015
Image: The buildup of fatty substances in blood vessels caused by atherosclerosis stiffens and narrows the blood vessels resulting in the death of heart muscle (Photo courtesy of [US] National Heart, Lung, and Blood Institute).

Nanoparticle Packaging Dramatically Increases Potency of Anti-Cardiovascular Disease Drug

The use of biodegradable polymer nanoparticles to encapsulate a promising drug for treating atherosclerosis increased its residence time in the body of a treated mouse from less than one hour to at least four hours.  More...
06 Jul 2015
Image: Neurons cultivated with the help of ordinary skin cells create a three-dimensional network on a chip (Photo courtesy of Dr. Edinson Lucumi Moreno, University of Luxembourg).

Bioreactor Culture of Dopamine-Producing Neurons May Lead to Personalized Treatment of Parkinson's Disease

By developing a procedure for transforming skin cells into functional dopamine-producing neurons, researchers have taken an important first step towards the development of personalized treatment of Parkinson's disease.  More...
05 Jul 2015

Phage Lytic Enzyme Specifically Attacks MRSA

A novel bacteriophagic protein has been designed to attack methicillin-resistant Staphylococcus aureus (MRSA) microbes and dissolve them.  More...
01 Jul 2015
Image: Histological section of two mouse melanomas: (a) untreated and (b) treated with sitagliptin, a specific DPP4 inhibitor (Photo courtesy of Institut Pasteur).

Diabetes Drug Shows Promise as an Anticancer Immunotherapeutic Agent

Treatment with the anti-diabetes drug sitagliptin of some types of cancer in a mouse model was found to increase the infiltration of T lymphocytes into tumors and, in combination with existing immunotherapies, eradicate the tumor.   More...
30 Jun 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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