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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Drug Discovery

Image: Tumor growth in the xenograft bladder cancer model was monitored using a bioluminescence imaging system. Forty-five days after inoculation, metastatic tumors were detected in the lungs, liver and bone (Photo courtesy of Scientific Reports).

Flufenamic Acid Slows Spread of Bladder Cancer in Mouse Model

The enzyme aldo-keto reductase 1C1, which could be suppressed by the anti-cold drug flufenamic acid, was found to be highly active in metastatic human bladder cancer and represents a potent molecular target for treating the disease. More...
26 Oct 2016
Image: A microscopic view of a typical neuroblastoma with rosette formation (Photo courtesy of Dr. Maria Tsokos, National Cancer Institute).

Neuropeptide May Serve as Biomarker for Neuroblastoma Patients

A study has found the common nerve protein Neuropeptide Y (NPY) to be elevated in the blood of those with an aggressive form of neuroblastoma, suggesting that NPY could serve as biomarker in a prognostic and/or treatment monitoring test, and as a new target for developing a more effective therapeutic drug for this early childhood cancer. More...
26 Oct 2016
Image: Neutralizing antibodies that bind to specific antigens on the flu virus may aid in the development of a universal influenza vaccine (Photo courtesy of Dr. Matthew Miller, McMaster University).

Mechanism Described for Cytotoxicity Regulation against Influenza A

A new discovery that revealed how neutralizing antibodies bind to specific antigens on the flu virus may aid in the development of a universal influenza vaccine. More...
20 Oct 2016
Image: Researchers have found that injecting nanoparticles into an injured joint can inhibit the inflammation that contributes to the cartilage damage seen in osteoarthritis. Shown in green is an inflammatory protein in cartilage cells. After nanoparticles are injected, the inflammation is greatly reduced (Photo courtesy of the Pham Laboratory, Washington University School of Medicine).

RNA-Based Therapy Reverses Cartilage Damage in Osteoarthritis

A novel treatment for osteoarthritis (OA) is based on a nanoparticle delivery system that transports a specific anti-inflammatory siRNA (short interfering RNA) to the chondrocytes in damaged cartilage. More...
19 Oct 2016
Image: A mouse model was used to show that microRNA miR-1298 specifically killed cancer cells with a common mutation in the KRAS gene (Photo courtesy of University of California, San Diego).

Proteins Identified Block Growth of KRAS-Mutant Cancers

A team of cancer researchers has defined a novel regulatory pathway in KRAS-driven cancers, which offers a potential therapeutic target for their eradication. More...
18 Oct 2016
Image: Alpha-synuclein aggregates in the brain cells of mice with (top) and without (bottom) the LAG3 protein (Photo courtesy of Dr. Xiaobo Mao, Johns Hopkins University).

Protein Found Blocks Transmission of Cytotoxic Fibrils in Parkinson's Disease Model

Neurodegenerative disease researchers have identified a protein that promotes the spread of toxic alpha-synuclein complexes in the brains of mice serving as a model system for human Parkinson's disease (PD). More...
12 Oct 2016
Image: A three-dimensional (3D) molecular space-filling model of resveratrol (Photo courtesy of Wikimedia Commons).

Mechanism Explains How Resveratrol Reduces Upper Respiratory Inflammation

The red wine component resveratrol reduces inflammation in the upper respiratory tract by enhancing the activity of the protein MyD88 short, a negative regulator of inflammatory signaling pathways. More...
12 Oct 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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