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10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016

Drug Discovery

Image: SCA10 – An experimental drug has been designed to correct cell defects in diseases such as spinocerebellar ataxia type 10 (Photo courtesy of DTR).

Experimental Drug Targets Diseases Caused by Toxic RNA Nucleotide Repeats

A small molecule drug designed to interact with defective RNA was shown to displace sequestered proteins and correct defects in cells derived from patients suffering from the incurable neuromuscular disorder spinocerebellar ataxia type 10 (SCA10). More...
15 Jun 2016

Role of Laminin Defined in Muscular Dystrophy-Related Stem Cell Differentiation

The structural protein laminin has been found to play a critical role in determining whether a class of stem cells linked to the development of muscular dystrophy (MD) matures into muscle – which could prevent development of MD – or into fat – which would contribute to the development of MD. More...
13 Jun 2016
Image: ProAgio (green) binding to integrin v3 (Photo courtesy of Georgia State University).

Experimental Drug Stops Cancer Growth by Activating Integrin-Based Apoptosis

An experimental drug blocks tumor growth by binding to a novel site on the surface receptor integrin alphavbeta3, which activates the apoptotic factor caspase 8 and leads to the death of the cancer cells. More...
13 Jun 2016

Drug Resistance in Cancer Cells Linked to Changes in MicroRNA Expression

Cancer researchers have linked development of resistance to chemotherapy in pancreatic cancer cells to the downregulation of a specific microRNA (miRNA). More...
09 Jun 2016

Lack of Gene that Protects Mice Promotes Anti-Viral Immunity in Humans

Researchers have resolved the question of why a gene that plays an important role in protecting mice from viral infection does not have a similar role in humans. More...
08 Jun 2016

Mouse Model Advances Drug Development for Treating Lymphoma and Melanoma

Cancer researchers have established a mouse model system to study the involvement of EZH2 histone methyltransferase (EZH2) mutations in the development of lymphoma and melanoma tumors. More...
02 Jun 2016

Non-Toxic Drug Combination Induces Stress that Kills Cancer Cells

Growth of several different types of cancers was blocked by combined treatment with the sugar 2-Deoxy-D-glucose (2-DG) and the cholesterol-lowering drug fenofibrate. More...
31 May 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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