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10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Drug Discovery

Photoactivated Nanoparticles Block Pancreatic Cancer Growth and Metastasis in Mouse Models

A nanoparticle delivery system was used for the safe transport a photodynamic therapy agent together with a highly toxic anti-cancer drug for the pinpoint treatment of pancreatic cancer.  More...
01 Feb 2016

Antibodies Isolated from Ebola Survivors Recognize Wide Range of Ebolavirus Species

A team of molecular virologists has isolated human monoclonal antibodies from Ebola survivors that were able to neutralize multiple species of the virus and protect guinea pigs from challenge with the live virus.  More...
01 Feb 2016
Image: The “cellXpress” automated imaging analysis software enables to efficiently and accurately detect cellular responses (reflected in green) to nephrotoxic compounds (Photo courtesy of Agency for Science, Technology and Research (Singapore)).

First High-Throughput Imaging Platform for Predicting Kidney Toxicity of Chemicals

Researchers have developed a high-throughput platform of automated cellular imaging that efficiently and accurately predicts renal toxicity of chemical compounds without animal testing, providing an improved approach to development of safer medicines and other chemical products.  More...
27 Jan 2016

Protein Identified That Boosts Brain Tumor Resistance to Chemotherapy

Cancer researchers have linked development of resistance to the anticancer drug temozolomide by glioblastoma multiforme brain cancer cells to the activity of the RhoG-specific guanine nucleotide exchange factor protein SGEF.  More...
26 Jan 2016

Exosome Delivery Dramatically Boosts Anticancer Drug Potency

The use of exosome nanoparticles to transport the anticancer drug paclitaxel was shown to dramatically reduce the amount of drug required to kill lung cancer cells in culture and in a mouse model.  More...
25 Jan 2016

Key Finding May Lead to Improved Treatment of Aggressive Brain Cancers

Researchers have shown an essential role for the cell microenvironment in the growth of glioblastoma brain cancer cells, a discovery that could lead to a breakthrough in fighting such deadly cancers.  More...
20 Jan 2016

Blocking ERK Signaling Inhibits Growth of Some Pancreatic Cancer Cell Lines

A recent paper discussed the potential of a drug that suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines by blocking the ERK component of the RAF-MEK-ERK molecular pathway.  More...
19 Jan 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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