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12 Nov 2016 - 16 Nov 2016
16 Nov 2016 - 19 Nov 2016

Drug Discovery

Novel Treatment Uses Bacteria Engineered to Delivery Pulses of Anti-Cancer Drugs

A novel method for treating liver tumors is based on genetically engineered bacteria that respond to population pressure by lysing and releasing pulses of anti-cancer drugs. More...
01 Aug 2016

Inhibitors of a Mutant Kinase May Be Potential Treatment for Parkinson's Disease

A potential therapeutic approach for treatment of Parkinson's disease is based on drugs that block the activity of a mutated version of the enzyme LRRK2 (Leucine-rich repeat kinase 2). More...
01 Aug 2016

Inhibiting Glutamine Metabolism Blocks Growth of Some Colorectal Tumors

Cancer researchers have found a way to block growth of colorectal tumors that express a mutation, which enables the cancer cells to use glutamine as their primary energy source. More...
01 Aug 2016

Newly Described Intellectual Disability Syndrome Caused by Damage to Single Gene

Scientists have discovered that the gene for transcription factor BCL11A is responsible for a previously unidentified intellectual disability and have identified a mechanism by which loss-of-function BCL11A mutations can lead to cognitive disability. The findings could lead to new targeted therapies and diagnostic tests for this disorder. More...
01 Aug 2016
Image: Fungi can be stimulated with distinct substances for production of antibiotic metabolic products (Photo courtesy of BiMM Research).

Fungi Exposed to Valproic Acid Produce Substances with Potential Antibiotic Properties

Drug developers have used valproic acid (VPA) to coax various types of fungi to produce "cryptic" bioactive molecules, some of which have potential as antibiotic agents. More...
27 Jul 2016
Image: A photomicrograph of Toxoplasma gondii tachyzoites, stained with Giemsa (Photo courtesy of the CDC).

New Model Boosts Development of Drugs to Treat Toxoplasmosis

A novel model system to facilitate development of drugs to treat toxoplasmosis and other parasitic infections is based on a strain of Toxoplasma gondii that produces cysts in vitro that mimic those found in living animals. More...
26 Jul 2016
Image: An artist’s concept of how a candidate drug fits precisely in BRD9\'s deep bromodomain binding pocket. In preclinical tests, the drug\'s binding prevented AML cells from proliferating (Photo courtesy of Vakoc Lab, Cold Spring Harbor Laboratory).

Success of Anti-Leukemia Compound Expected to Boost Drug Development Efforts

Cancer researchers have identified the active site of a protein required for growth and spread of the blood cancer acute myeloid leukemia (AML), and have designed a drug that blocks the site and suppresses the proliferation of mouse and human AML cell lines in vitro. More...
18 Jul 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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