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Drug Discovery

Image: Crystal structure of the immunoproteasome (Photo courtesy of the department of biochemistry, TUM).

Drug Development Advance for Treatment of Autoimmune Diseases, Chronic Inflammation Disorders

The immune system functions as the body’s protectors, defending it from intruders such as bacteria and viruses. However, to ascertain what is happening in the cell, the immune system requires information on the foreign invaders. This chore is taken on by protein complexes called immunoproteasomes. These are cylindrical complexes break down the protein structures of the intruders into fragments that can be used by the defense system.   More...
07 Oct 2014

MRI Technology Enables Noninvasive Monitoring of Emergent Cell Therapies

Cellular therapeutics, the application of using intact cells to treat and cure disease, is an important potential new therapeutic application, but it is hampered by the inability of clinicians and scientists to effectively monitor the destination, movements, and perseverance of these cells in patients without having to use invasive procedures, such as tissue sampling.   More...
07 Oct 2014

Protein Maps to Help Develop Powerful New Cancer Drugs

Chemical scientists have gained new insights into how a disease-causing enzyme makes changes to proteins and how to block it. The scientists hope their findings will help them to design drugs that could target the enzyme, known as N-myristoyltransferase, and potentially lead to new treatments for cancer and inflammatory conditions.   More...
06 Oct 2014

Blocking Binding of Bacteria to Fibrinogen Prevents Biofilm Formation and Catheter-Associated Bladder Infection in Mice

A team of molecular microbiologists has identified and targeted a critical step in biofilm formation and developed a vaccine that prevents catheter-associated urinary tract infections in mice.  More...
30 Sep 2014

MicroRNA Mimic Shown to Reverse Effects of Pulmonary Fibrosis

A potential new treatment that reverses the effects of pulmonary fibrosis, a respiratory disease in which scars develop in the lungs and greatly suppress breathing, is being assessed by scientists.  More...
29 Sep 2014
Image: S-649266 has more robust antibacterial activity than established antibiotics against multidrug-resistant bacteria (Photo courtesy of Shionogi).

Novel Antibiotic Shows Potential for Broad Range of Infections

The emergence of bacterial resistance to known antibacterial agents is becoming a major challenge in treating the infection caused by multi drug resistant bacteria.   More...
23 Sep 2014

Ibuprofen May Restore Immune Function in Older Individuals

New research suggests that macrophages from the lungs of old mice respond differently to infections than those of young mice, and ibuprofen given to the mice reversed these changes.  More...
17 Sep 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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