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Drug Discovery

Novel Class of Drug Delivery Liposomes Fail to Trigger an Adverse Immune Response

A novel class of liposomes prepared from the artificial phospholipid Pad-PC-Pad releases drugs at the site of arterial blockage, and has been shown to avoid activation of deleterious immune responses.  More...
22 Mar 2016
Image: Mode of action of the dual cyclin kinase inhibitor ON123300 (Photo courtesy of Onconova Therapeutics).

Dual Cyclin-Dependent Kinase Inhibitor Effective Against Multiple Myeloma in Preclinical Studies

Results obtained during preclinical studies support the continued development of a dual cyclin-dependent kinase inhibitor for the treatment of multiple myeloma.  More...
16 Mar 2016

Experimental Drug Blocks Leukemia Growth in Mouse Model System

An experimental drug that blocks the activity of a specific histone demethylase enzyme was found to cure the TAL-1 form of acute T-cell lymphoblastic leukemia in a mouse model system.  More...
14 Mar 2016

MicroRNA-Nanoparticle Complexes Prevent Growth of Osteosarcoma Cells

Cancer researchers developed a nanoparticle delivery system to transport dormancy-inducing microRNAs into osteosarcoma cells.  More...
08 Mar 2016

Potential Alzheimer's Disease Drug Selectively Blocks Endosomal Beta-Secretase Activity

Alzheimer's disease researchers have developed a drug that blocks the disease-related activity of the enzyme beta-secretase without affecting other interactions that are not related to AD.  More...
08 Mar 2016

Structural Analysis Reveals Potential Coronavirus Vaccine Targets

High-resolution analysis of the coronavirus spike glycoprotein has revealed common binding, fusion, and antigenic sites that may be exploited for the development of a broad spectrum vaccine against this family of viruses that includes the human pathogens SARS-CoV and MERS-CoV.  More...
06 Mar 2016

Synthetic Nucleic Acids Restore Normal Frataxin Levels in Patient-Derived Friedreich's Ataxia Cells

Neurological disease researchers have used synthetic nucleic acid polymers to block the defective FXN gene segment and restore normal levels of frataxin in cells derived from patients with Freidreich's ataxia.  More...
02 Mar 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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