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Drug Discovery

Antibodies against Complement Factor H Selectively Destroy Tumor Cells

Cancer researchers have identified and produced a monoclonal antibody that destroys tumor cells by blocking the activity of the protective protein complement factor H (CFH). More...
17 May 2016

Stem Cells Induced by Low Molecular Weight Compounds Transform into Working Heart and Brain Cells

A team of cell biologists has demonstrated the feasibility of using cocktails of low molecular weight compounds to induce skin cells to revert to a stem cell-like state that allowed them to be reprogrammed into cardiac or neural cells. More...
12 May 2016

Nanoparticle Treatment Prevents Herpes Infection in Mouse Model

A novel type of nanoparticle was shown to effectively prevent infection by herpes simplex virus-2 (HSV-2), the virus that causes chronic genital herpes. More...
10 May 2016

Adenoid Cystic Carcinoma Stem Cells Depend on NOTCH1 and SOX10 Signaling

Cancer researchers have isolated a stem cell population from the cells making up an adenoid cystic carcinoma (ACC) tumor and showed that the signaling factors NOTCH1 and SOX10 were essential for the cancer stem cells to proliferate and resist radiation treatment. More...
05 May 2016

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. More...
04 May 2016
Image: A confocal microscopy image of stem cells loaded with drug containing polymeric microparticles (Photo courtesy of Jeff Karp and Oren Levy, Brigham and Women\'s Hospital).

Cells Loaded with Prodrug-Containing Microparticles Selectively Destroy Prostate Cancer Tumors

A novel approach to treating metastatic prostate cancer with minimal adverse side effects is based on cellular transport of a harmless prodrug that is activated and becomes toxic only in the vicinity of the tumor microenvironment. More...
02 May 2016

X-ray Crystallography Study May Lead to New Drugs to Block Cancer Metastasis

Cancer researchers expect that the structure of the enzyme P-Rex1 (PIP3-dependent Rac exchanger 1), which was recently established by X-ray crystallography, will lead to development of a new generation of cancer chemotherapeutic agents to block the processes leading to metastasis. More...
28 Apr 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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