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Drug Discovery

Mini-Organism-on-a-Chip May Replace Test Animals in Drug Studies

A team of German biomedical researchers has developed a highly miniaturized micro-circulatory system for testing the response of various body organs to drugs or other chemicals.  More...
16 Feb 2015
Image: Space-filling molecular model of epigallocatechin gallate (EGCG)(Photo courtesy of Wikimedia Commons).

Alternative Cancer Treatments May Be Based on Green Tea Components

A recent paper suggested that the green tea component epigallocatechin-3-gallate could be developed into an alternative treatment for oral cancer that would not have the severe side effects of current chemotherapeutic agents.   More...
10 Feb 2015
Image: Micrograph showing a rat cell re-programmed to express HNF-6 (red) and insulin (green). The nucleus is stained blue (Photo courtesy of Cornell University).

Genetically Engineered Lactobacilli Cure Diabetes in Rat Model

A novel concept for treating diabetes was demonstrated by feeding diabetic rats a diet containing human lactobacilli that had been genetically engineered to secrete the protein glucagon-like peptide-1 GLP-1, which induced significant long-term increases in insulin levels.   More...
09 Feb 2015

Defective Cell Extrusion May Lead to Formation of Tumors in Pancreas, Lungs, or Colon

The disruption of normal S1P2 receptor activity in epithelial cells prevents the pro-apoptotic extrusion of cells from overcrowded tissue and leads to the formation of cancerous growths in the pancreas, lung, and colon.  More...
09 Feb 2015

Time-Release Microcapsules Deliver Anti-Inflammatory Hormone to Repair Cartilage Damaged by Osteoarthritis

Microcapsules loaded with C-type natriuretic peptide have been shown to reduce the type of inflammation characteristic of osteoarthritis in a model system based on the culture of animal cartilage tissue.   More...
03 Feb 2015
Image: A series of transmission electron microscopy (TEM) images shows the transition from cylindrical precursor nanoparticles to spherical nanoparticles (Photo courtesy of Dr. Andrew Dove, University of Warwick).

Self-Assembled Polymer Complexes Have Potential Drug Delivery Role

Drug developers have demonstrated the possibility of using mixtures of inert polymers with different configurations and tacticities that self-assemble without outside stimulus to construct active particles that have potential use for controlled release and delivery applications.  More...
28 Jan 2015
Image: The calcium influx into the liver carcinoma cell can be monitored following the exposure to citronellal (pictured in pseudo-colors) (Photo courtesy of Ruhr-University Bochum).

Citrus Scent Found to Suppress Liver Cancer

Essential oils exist in many plants, protecting them through their antibacterial, antiviral, and fungicidal properties. It has been recently discovered that terpenes, the oils’ chief components, can also suppress the growth of different cancer cells, including liver cancer. Their function had not previously been fully understood.   More...
28 Jan 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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