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Drug Discovery

Silicon Microparticles Boost Effectives of Potential Breast Cancer Vaccines

Microparticles constructed from porous silicon were found to increase the effectiveness of potential anti-breast-cancer vaccines by stimulating a type I interferon response even when not carrying any specific antigen.  More...
19 May 2015

DNA and Protein Composite Vaccine Produces Long Lasting Immunity Against Chagas Disease in Mice

A candidate vaccine for Chagas disease was found to induce long-lasting immunity against the Trypanosoma cruzi parasite in mice.  More...
17 May 2015

Blocking ITK Activity Slows Growth of Malignant Melanoma in Mouse Model

Development of malignant melanoma was found to depend to some extent on the activity of the enzyme produced by the gene interleukin-2 inducible T-cell kinase.  More...
13 May 2015

Crystallography Study Reveals Details of Angiotensin Receptor Structure

Researchers working with one of the world's most powerful free-electron X-ray lasers have established the crystal structure of the protein angiotensin II type 1 receptor, an important blood pressure regulator in the human body.  More...
11 May 2015

Honokiol Prevents Hypertrophy in Mice by Increasing Mitochondrial Sirt3 Activity

The ancient herbal therapy substance honokiol, which is derived from the bark, seed cones, and leaves of trees belonging to the genus Magnolia, has been found in a recent study to have chemical properties that enable it to protect the heart from hypertrophy.  More...
26 Apr 2015

Leaky Calcium Channels Promote Development of Diabetes

Chronic leakage from cellular calcium channels has been linked to a rare type of exercise-induced cardiac arrest and has been shown to cause glucose intolerance, suggesting that it might be involved in the development of type II diabetes.  More...
19 Apr 2015
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease in a mouse model.  More...
13 Apr 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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