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Drug Discovery

New ELISA Kit Measures Drug-Induced DNA Breaks

A gamma H2AX pharmacodynamic assay kit for the study of double strand DNA breaks through the detection of the phosphorylated histone, gamma-H2AX, is now available for drug developers as well as biotech and other life science researchers.  More...
07 Sep 2014

Naphthalene-Dipeptide Hydrogels Destroy Antibiotic-Resistant Bacterial Biofilms

Novel hydrogels derived from self-assembling dipeptides conjugated to naphthalene were shown to dissolve bacterial biofilms, which indicated considerable promise for use in constructing bacteria-resistant nanomaterial structures, biomaterials, and drug delivery devices.  More...
03 Sep 2014
Image: (Left) Neurons in brains from people with autism do not undergo normal pruning during childhood and adolescence. The images show representative neurons from unaffected brains (left) and brains from autistic patients (right); the spines on the neurons indicate the location of synapses (Photo courtesy of Guomei Tang, PhD and Mark S. Sonders, PhD, Columbia University Medical Center).

Autistic Youngsters Found to Have Too Many Brain Synapses

Autistic children and adolescents have been shown to have an excess of brain synapses, and this is due to a slowdown in the normal brain “trimming” process during development, according to new findings.   More...
02 Sep 2014
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions.  More...
26 Aug 2014

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice.  More...
25 Aug 2014

Novel Antibody Obliterates Plaque Psoriasis

New studies show that treatment of longstanding plaque psoriasis with secukinumab, a fully human anti-interleukin-17A monoclonal antibody, was associated with rapid and dramatic improvements.  More...
24 Aug 2014

Surface Protein Protects Brain Tumor Cells from Immune Attack

Malignant glioma brain tumor cells suppress the natural killer cell immune response by over expressing the surface protein galectin-1, and suppression of this protein renders the tumor cells susceptible to destruction by the immune system.   More...
19 Aug 2014


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 
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