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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Drug Discovery

Antibody-Zika Virus Interaction Visualized by Cryo-Electron Microscopy

An international team of molecular virologists used advanced cryo-electron microscopy (cryoEM) techniques to visualize how the potent anti-Zika virus antibody C10 acts to prevent the virus from infecting human cells. More...
07 Dec 2016

Blocking the Acsl14 Enzyme Prevents Ferroptosis-Linked Cell Death

Inhibiting the enzyme Acsl4 (acyl-CoA synthetase long-chain family member 4), which is involved in fatty acid metabolism, has been postulated to be a viable therapeutic approach to preventing ferroptosis-related diseases. More...
25 Nov 2016

DNA-barcode Labeled Nanoparticles Trace Drug Susceptibility

Novel DNA-barcoded nanoparticles loaded with anti-cancer drugs were used to screen for susceptibility at the cellular level as a first step in the development of personalized cancer therapy. More...
23 Nov 2016

Blocking Mutant RNA Cures Huntington's Disease in Mouse Model

Researchers seeking ways to treat Huntington's disease have suggested going after the messenger RNA that mediates between the mutant gene that causes the disease and the toxic protein that causes the neurological damage that characterizes it. More...
23 Nov 2016

Mitochondrial Protein Linked to Development of Prostate Cancer

Results obtained from experiments with genetically engineered mouse models revealed a direct link between the mitochondrial chaperone protein, TRAP1 (TNF receptor associated protein 1) and the development of prostate cancer. More...
23 Nov 2016

DNA-based Zika Vaccine Demonstrates Potential in Animal Models

A DNA-based vaccine has shown promise in protecting animal models against infection and brain damage caused by the Zika virus. More...
22 Nov 2016

Experimental Monobody Drug Inhibits Most Mutated RAS Oncogenes

A novel monobody drug candidate was found to effectively block the action of most of the RAS family of proto-oncogenes, which are mutated in nearly 90% of pancreatic cancers and are also highly prevalent in colon cancer, lung cancer, and melanoma. More...
17 Nov 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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