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Drug Discovery

Image: Micrograph of the Gram-positive bacillus C. sporogenes (Photo courtesy of the University of Pennsylvania).

Inactivated Bacteria and Excreted Factors for Colorectal Cancer Treatment

Inactivated Clostridium sporogenes bacteria and medium harvested after growth of the bacteria were found to be potent inhibitors of colorectal cancer cells growing on two- and three-dimensional culture platforms.  More...
22 Nov 2015
Image: Ring structure of the RAD52 protein (Photo courtesy of Wikimedia Commons).

Potential Drug Candidate Blocks Alternate DNA Repair Route in BRCA-Mutated Cancer Cells

Cancer researchers have identified a low molecular weight compound that inhibits the RAD52 DNA repair protein and kills cancer cells with a BRCA mutation by blocking the alternate DNA repair route.  More...
22 Nov 2015

Bacterial Curli Fibers Reverse Symptoms of Inflammatory Bowel Disease in Mouse Model

A novel treatment for inflammatory bowel disease based on oral administration of a single dose of purified curli fibers was successfully tested in a mouse model of acute colitis.  More...
11 Nov 2015

New Study Explains How Some Cancers Survive Histone Deacetylase Inhibitor Treatment

Cancer researchers believe that they now understand why some types of tumor cells are resistant to an important class of drugs known as histone deacetylase inhibitors.  More...
10 Nov 2015
Image: MRI renderings of mouse brain tumors. Tumors treated with SKOG102 (lower panels) shrank by about half compared to tumors treated with a control (upper panels) (Photo courtesy of the University of California, San Diego).

Transcription Factor Inhibitors Block Growth of Lethal Brain Tumor

A new approach for treating the deadly brain tumor glioblastoma multiforme is based on small molecule inhibitors of the major class of protein signaling molecules known as transcription factors, which are essential for tumor survival and growth.  More...
10 Nov 2015

Nanoparticle Targeting May Revolutionize Cardiac Photoablation Therapy

A light-based therapeutic approach to correct cardiac arrhythmia has been improved by the development of a nanotechnique that allows precise delivery of photosensitive molecules to malfunctioning cardiomyocytes while avoiding normal cells.   More...
09 Nov 2015
Image: Structure of the ferritin complex. The toxic anticancer drug daunorubicin was sequestered at the core of the molecule, protected by the protein coat (Photo courtesy of Wikimedia Commons).

Apoferritin-Based Nanocapsules Used to Transport Toxic Anticancer Drug

A toxic anticancer therapeutic agent was encapsulated in capsules derived from apoferritin, which sequestered the drug until its selective delivery to cancer cells.  More...
08 Nov 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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