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Drug Discovery

Image: Endoscopic image of a bowel section known as the sigmoid colon afflicted with ulcerative colitis. The internal surface of the colon is blotchy and broken in places (Photo courtesy of Wikimedia Commons).

Orally Delivered Curcumin-Loaded Microparticles Effectively Treat Mouse Model of Ulcerative Colitis

Microparticles loaded with the efficient anti-inflammatory agent curcumin were found to effectively treat a mouse model of ulcerative colitis.  More...
29 Sep 2015

Biopharmaceutical Partners Seek Alternatives to Glucocorticoid Steroid Drugs

Collaboration between American and Japanese biopharmaceutical companies is expected to lead to the development of a new class of small molecule drugs for treatment of hematological and inflammatory diseases.  More...
28 Sep 2015
Image: A small liquid plug in the bronchus was manipulated by air ventilation to deliver a drug into the most distant alveoli (Photo courtesy of Dr. Jinho Kim, Columbia University).

Mathematical Models Guide Microliter Doses of Drugs to Specific Pathological Sites in the Lungs

A recent paper described a novel technique for precise delivery of microliter quantities of drugs directly to selected pathological areas in the lungs.  More...
16 Sep 2015
Image: During the process of cell division, the mitochondria are damaged (yellow indicator) making the cells particularly dependent on glucose as a source of energy. Genetic material is shown in blue and mitochondria in red (Photo courtesy of the Spanish National Cancer Research Center).

Blocking Glycolysis Helps Antimitotic Chemotherapeutic Drugs to Work Better

Blocking the attempts of tumor cells to establish glycolysis as their primary means of generating energy was found to significantly augment the chemotherapeutic benefits of drugs that prevent the cells from dividing.  More...
15 Sep 2015

Toxic Peptide from Wasp Venom Targets Cancer Cell Membrane Phospholipids

A toxic peptide component of the venom produced by a South American wasp effectively destroys some types of cancer cells through interactions with groups of phospholipids that are distributed abnormally on their cell membranes.  More...
15 Sep 2015
Image: Cancerous melanoma cells, shown with their cell bodies (green) and nuclei (blue), are nestled in tiny hollow lumens within the polymeric cryogel (red) structure (Photo courtesy of the Wyss Institute at Harvard University).

Mouse Model Shows Potential of Personalized Cancer Treatment Based on Live Cell Vaccination

A novel personalized approach to cancer immunotherapy is based on sponge-like "cryogels" that are loaded with a sampling of the patient's tumor cells together with immune system-stimulating reagents and then injected under the skin.  More...
08 Sep 2015
Image: Molecular model of CD38 (Photo courtesy of Wikimedia Commons).

Clinical Trial Confirms Potential of Candidate Antimyeloma Drug

The candidate drug daratumumab, which is a monoclonal antibody that targets the cell surface molecule CD38, was shown to be a safe and effective treatment for multiple myeloma in a combined phase I/II clinical trial.  More...
08 Sep 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
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