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Drug Discovery

Gold Nanotubes Are Novel Agents for Cancer Diagnosis and Treatment

Cancer researchers have produced a highly defined class of gold nanotubes that are suitable for use in animals as in vivo imaging nanoprobes, photothermal conversion agents, and drug delivery vehicles.  More...
03 Mar 2015

Double Targeting Approach Increases Potential for Cancer Treatment with Oncolytic Viruses

Cancer researchers have used a double targeting approach to direct oncolytic viruses specifically to tumor cells where they reproduce until the cancer cells burst, releasing more viruses to infect and ultimately destroy the tumor.  More...
02 Mar 2015

Cell Biologists Find That Certain Mitochondrial Diseases Stem from Coenzyme Q10 Depletion

A team of German cell biologists has linked the development of certain mitochondrial-linked diseases to depletion of the organelles' pool of coenzyme Q10 brought about by mutation in the MFN2 gene, which encodes the fusion protein mitofusin 2.  More...
25 Feb 2015
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C and the phospholipid dioleoylphosphatidylserine were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.  More...
24 Feb 2015
Image: The micrograph shows a multilayered three-dimensional \"organotypic\" platform for quantitative high-throughput screening to identify new therapeutics for ovarian cancer. Fibroblasts are red. Mesothelial cells are blue. Ovarian cancer cells are green. The square image is the XY-planes (up-down, right-left). The images on the sides are Z-planes (depth) (Photo courtesy of Lengyel laboratory, University of Chicago).

Culture-Based High Throughput Screen Detects Potent Anti-Ovarian Cancer Drugs

Cancer researchers have developed a high throughput system for screening drugs against ovarian tumors that is based on inhibition of cancer cells growing in a three-dimensional culture system.  More...
23 Feb 2015
Image: Eve, the robot scientist (Photo courtesy of the University of Manchester.

Robot Screening System Streamlines Discovery of New Drug Compounds

British drug developers have automated the drug discovery process by using a "robot scientist" to screen thousands of potential candidate compounds.  More...
23 Feb 2015
Image: Nanoparticles in low and high resolution micrographs (Photo courtesy of Green Laboratory, Johns Hopkins University).

Nanoparticles Deliver Viral Gene That Activates Toxic Drug Inside Brain Cancer Cells

Cancer researchers have described a nanoparticle-based gene therapy system that inserted the gene for the enzyme herpes simplex virus type I thymidine kinase into brain tumor cells and rendered them highly sensitive to the chemotherapeutic agent ganciclovir.  More...
17 Feb 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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