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Drug Discovery

Image: A series of transmission electron microscopy (TEM) images shows the transition from cylindrical precursor nanoparticles to spherical nanoparticles (Photo courtesy of Dr. Andrew Dove, University of Warwick).

Self-Assembled Polymer Complexes Have Potential Drug Delivery Role

Drug developers have demonstrated the possibility of using mixtures of inert polymers with different configurations and tacticities that self-assemble without outside stimulus to construct active particles that have potential use for controlled release and delivery applications.  More...
28 Jan 2015
Image: The calcium influx into the liver carcinoma cell can be monitored following the exposure to citronellal (pictured in pseudo-colors) (Photo courtesy of Ruhr-University Bochum).

Citrus Scent Found to Suppress Liver Cancer

Essential oils exist in many plants, protecting them through their antibacterial, antiviral, and fungicidal properties. It has been recently discovered that terpenes, the oils’ chief components, can also suppress the growth of different cancer cells, including liver cancer. Their function had not previously been fully understood.   More...
28 Jan 2015

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.  More...
28 Jan 2015

Norovirus Interacts with Gut Bacteria to Establish a Persistent Infection That Can Be Blocked by Interferon Lambda

A team of molecular microbiologists and virologists has found that norovirus requires an intimate interaction with certain gut bacteria to establish a persistent infection, and that the infective process can be blocked by the immune factor interferon lambda.  More...
27 Jan 2015

Curcumin Used to Treat Alzheimer’s Disease

Curcumin, a natural substance found in the spice turmeric, has been used by many Asian cultures for centuries. Now, new research suggests that a close chemical analog of curcumin has properties that may make it useful as a treatment for Alzheimer’s disease.  More...
26 Jan 2015
Image: Researchers have attached two drugs—TRAIL and Dox—onto graphene strips. TRAIL is most effective when delivered to the external membrane of a cancer cell, while Dox is most effective when delivered to the nucleus, so the researchers designed the system to deliver the drugs sequentially, with each drug hitting a cancer cell where it will do the most damage (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Anticancer Drug Delivery System Utilizes Graphene Strip Transporters

The ongoing search by cancer researchers for targeted drug delivery systems has generated a novel approach that uses graphene strips to transport simultaneously the anticancer agents TRAIL and Dox.  More...
20 Jan 2015

Blueberries Shown to Pack Big Heart Health Benefits

Just one cup of blueberries per day could be the enough to reduce blood pressure and arterial stiffness, both of which are linked with cardiovascular disease.   More...
20 Jan 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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