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Drug Discovery

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems.  More...
16 Oct 2014
Image: Microscope images of the bacteria P. acnes left untreated (A, B) or incubated for 24-hours (C, D) with resveratrol. Images were taken at 10,000 x magnification (A, C) or 29,000 x magnification (B, D) (Photo courtesy of the University of California, Los Angeles).

Combined Resveratrol and Benzoyl Peroxide Treatment Effectively Kills Acne Bacteria

A combination of the common acne medication benzoyl peroxide and the anti-oxidant resveratrol was found to be more effective in eradicating the bacteria responsible for acne than was benzoyl peroxide alone.  More...
15 Oct 2014
Image: Crystal structure of the immunoproteasome (Photo courtesy of the department of biochemistry, TUM).

Drug Development Advance for Treatment of Autoimmune Diseases, Chronic Inflammation Disorders

The immune system functions as the body’s protectors, defending it from intruders such as bacteria and viruses. However, to ascertain what is happening in the cell, the immune system requires information on the foreign invaders. This chore is taken on by protein complexes called immunoproteasomes. These are cylindrical complexes break down the protein structures of the intruders into fragments that can be used by the defense system.   More...
07 Oct 2014

MRI Technology Enables Noninvasive Monitoring of Emergent Cell Therapies

Cellular therapeutics, the application of using intact cells to treat and cure disease, is an important potential new therapeutic application, but it is hampered by the inability of clinicians and scientists to effectively monitor the destination, movements, and perseverance of these cells in patients without having to use invasive procedures, such as tissue sampling.   More...
07 Oct 2014

Protein Maps to Help Develop Powerful New Cancer Drugs

Chemical scientists have gained new insights into how a disease-causing enzyme makes changes to proteins and how to block it. The scientists hope their findings will help them to design drugs that could target the enzyme, known as N-myristoyltransferase, and potentially lead to new treatments for cancer and inflammatory conditions.   More...
06 Oct 2014

Blocking Binding of Bacteria to Fibrinogen Prevents Biofilm Formation and Catheter-Associated Bladder Infection in Mice

A team of molecular microbiologists has identified and targeted a critical step in biofilm formation and developed a vaccine that prevents catheter-associated urinary tract infections in mice.  More...
30 Sep 2014

MicroRNA Mimic Shown to Reverse Effects of Pulmonary Fibrosis

A potential new treatment that reverses the effects of pulmonary fibrosis, a respiratory disease in which scars develop in the lungs and greatly suppress breathing, is being assessed by scientists.  More...
29 Sep 2014


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 
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