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Drug Discovery

NADPH Oxidase Inhibitor Treatment Protects Mice from Being Killed by Pneumonia

Influenza sufferers who develop methicillin-resistant Staphylococcus aureus (MRSA) pneumonia often die from damage caused to their lungs by reactive oxygen species released from necrotic inflammatory cells. More...
25 Aug 2016

Magnetically Guided Bacteria Transport Drug-Loaded Liposomes to Hypoxic Tumors

A novel transport system for toxic chemotherapeutic drugs is based on a species of bacteria that can be magnetically guided to a tumor where it releases drug-loaded liposomes into the tumor's hypoxic center. More...
24 Aug 2016
Image: A photomicrograph of bone marrow aspirate showing acute myeloid leukemia (AML) (Photo courtesy of Wikimedia Commons).

Phase II Trial Confirms Potential of Venetoclax for Acute Myeloid Leukemia

Results of a Phase II clinical trial indicated that the candidate drug venetoclax was effective for treating patients whose acute myeloid (myelogenous) leukemia (AML) had relapsed or was resistant to chemotherapy. More...
24 Aug 2016

Antibiotics-Induced Changes to Gut Bacteria Influence Expression of Drug Side Effects

Antibiotic treatment disrupts the normal bacterial population of the gut resulting in changes in how the body deals with the breakdown and transport of drugs and other metabolites, which may increase the impact of deleterious side effects. More...
23 Aug 2016
Image: A kidney stone (yellow) composed of calcium oxalate showing sharp edges (Photo courtesy of Wikimedia Commons).

Hydroxycitrate Potentially More Effective Than Citrate for Kidney Stones

The chemical hydroxycitrate (HCA) was shown in a recent study to be more effective for treating calcium oxalate kidney stones than the commonly used compound potassium citrate. More...
18 Aug 2016

High-Resolution Cryo-EM Images Increase Understanding of Anti-Ebola Drug

High-resolution cryo-electron microscopy images have revealed more precise information as to how the experimental drug ZMapp binds to the Ebola virus and provide insights into how the drug prevents growth of the pathogen. More...
18 Aug 2016
Image: A transmission electron microgragh (TEM) of Deinococcus radiodurans (Photo courtesy of Dr. Michael Daly, Uniformed Services University of the Health Sciences).

Synthetic Antioxidant Peptide Protects Mice from Lethal Levels of Radiation

An antioxidant peptide compound that mimics those produced by the bacterium Deinococcus radiodurans was found to effectively protect cell cultures and mice exposed to lethal levels of gamma radiation. More...
18 Aug 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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