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10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016

Drug Discovery

Protein Linked to Destruction of Mitochondria in Huntington's Disease

Researchers studying the molecular mechanisms involved in Huntington's disease (HD) have identified a protein that binds to mutant huntingtin protein in the mitochondria of neurons, which results in destruction of the mitochondria and death of the nerve cells. More...
28 Sep 2016

Reactivation of p53 Shrinks Tumors in Mouse Model

Blocking a protein that inhibits lysine acetylation reversed the inactivation of the p53 protein and resulted in shrinkage of tumors in a mouse xenograft model. More...
27 Sep 2016

Light-Activated Nanoparticles Kill Primary Tumors and Distant Metastases

A novel type of nanoparticle carries two anticancer drugs to attack colorectal cancer while simultaneously recruiting and activating T-cells to fight the tumors. More...
27 Sep 2016

Novel Class of Nanoparticle Drug Transporters Selectively Target Lung Cancer Cells

A novel class of nanoparticles is able to deliver siRNA-based drugs selectively to lung cancer cells without harming normal cells. More...
26 Sep 2016

Inhibiting Enzyme Activity Overcomes Cell Differentiation Blockade

Inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) was found to stimulate differentiation of acute myeloid leukemia (AML) cells, which reduced the cancer cell burden and promoted survival in human and mouse models. More...
26 Sep 2016

Snail Insulin Serves as Drug Development Model

A form of insulin isolated from a type of carnivorous marine snail lacks the segment of the B region that causes the protein to aggregate, which decreases the amount of time required by the hormone to influence glucose levels by a factor of three. More...
22 Sep 2016

Stabilizing Iron-Sulfur Transport Clusters Reduces Size and Aggressiveness of Tumors

An international team of cancer researchers has identified a protein that, when overexpressed, enabled breast tumors to better withstand oxidative stress thereby becoming much larger and more aggressive. More...
21 Sep 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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