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Drug Discovery

Image: A scanning electron microscope (SEM) image of methicillin-resistant Staphylococcus aureus bacteria (Photo courtesy of the CDC).

Drug Combination Cures MRSA Infection While Preventing Development of Resistance

Treatment with a combination comprising the well-known antibiotic cefdinir and the experimental drug TXA709 cured mice of drug-resistant staphylococcal infections while reducing the development of resistance. More...
23 Jun 2016

Tobacco Mosaic Virus Nanoparticle Delivery System Increases Potency of Experimental Anticancer Drug

A candidate anticancer drug was found to be considerably more potent than standard treatments and this potency was further increased in a mouse model when the drug was delivered by a tobacco mosaic virus (TMV)-based transport system. More...
20 Jun 2016

Custom Designed Peptides Transport Hydrophobic Drug Compounds

A bioengineering team has designed a novel class of drug-delivery peptides that coalesce into a hydrogel capable of transporting hydrophobic compounds within the hydrophobic cores of the peptide nanofibers. More...
20 Jun 2016

Aptamer Prevents Serpin Misfolding without Damaging Protease Inhibition

A team of Danish molecular biologists has developed an aptamer that blocks misfolding of mutant serpin protease inhibitors while maintaining the protein's inhibitory function. More...
20 Jun 2016
Image: The new active ingredient consists of DARPins (red and orange) that bend the HER2 receptors (blue) so no more growth signal is transmitted into the cell interior (below the cell membrane in yellow) (Photo courtesy of the University of Zurich).

Novel Class of Drugs Selectively Kills HER2-positive Breast Cancer Cells

A team of Swiss drug developers has designed a novel drug that cures breast cancer by completely blocking the activity of the surface receptor HER2 (human epidermal growth factor receptor 2). More...
16 Jun 2016
Image: SCA10 – An experimental drug has been designed to correct cell defects in diseases such as spinocerebellar ataxia type 10 (Photo courtesy of DTR).

Experimental Drug Targets Diseases Caused by Toxic RNA Nucleotide Repeats

A small molecule drug designed to interact with defective RNA was shown to displace sequestered proteins and correct defects in cells derived from patients suffering from the incurable neuromuscular disorder spinocerebellar ataxia type 10 (SCA10). More...
15 Jun 2016

Role of Laminin Defined in Muscular Dystrophy-Related Stem Cell Differentiation

The structural protein laminin has been found to play a critical role in determining whether a class of stem cells linked to the development of muscular dystrophy (MD) matures into muscle – which could prevent development of MD – or into fat – which would contribute to the development of MD. More...
13 Jun 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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