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Drug Discovery

Image: Fungi can be stimulated with distinct substances for production of antibiotic metabolic products (Photo courtesy of BiMM Research).

Fungi Exposed to Valproic Acid Produce Substances with Potential Antibiotic Properties

Drug developers have used valproic acid (VPA) to coax various types of fungi to produce "cryptic" bioactive molecules, some of which have potential as antibiotic agents. More...
27 Jul 2016
Image: A photomicrograph of Toxoplasma gondii tachyzoites, stained with Giemsa (Photo courtesy of the CDC).

New Model Boosts Development of Drugs to Treat Toxoplasmosis

A novel model system to facilitate development of drugs to treat toxoplasmosis and other parasitic infections is based on a strain of Toxoplasma gondii that produces cysts in vitro that mimic those found in living animals. More...
26 Jul 2016
Image: An artist’s concept of how a candidate drug fits precisely in BRD9\'s deep bromodomain binding pocket. In preclinical tests, the drug\'s binding prevented AML cells from proliferating (Photo courtesy of Vakoc Lab, Cold Spring Harbor Laboratory).

Success of Anti-Leukemia Compound Expected to Boost Drug Development Efforts

Cancer researchers have identified the active site of a protein required for growth and spread of the blood cancer acute myeloid leukemia (AML), and have designed a drug that blocks the site and suppresses the proliferation of mouse and human AML cell lines in vitro. More...
18 Jul 2016

Blocking Formation of Scar Tissue Increases Susceptibility of Pancreatic Cancer to Immunotherapy

Cancer researchers have shown that treatment with a focal adhesion kinase (FAK) inhibitor rendered pancreatic cancer tumors susceptible to immunotherapy in a mouse model of the disease. More...
13 Jul 2016
Image: Left and right: Various species of Triatomine bugs, which if infected can transmit T. cruzi. Center: T. cruzi trypomastigote in a thin blood smear stained with Giemsa (Photo courtesy of the CDC).

Oral Nanocapsule Treatment Cures Mice with Chronic Phase Chagas Disease

Oral treatment with nanocapsules containing the Brazilian plant extract lychnopholide was shown to eradicate Trypanosoma cruzi in both the acute and chronic phases of Chagas disease. More...
30 Jun 2016

Structure of Enzyme for Trehalose Synthesis May Promote Drug Development

A team of molecular microbiologists has established the molecular structure of an enzyme required for synthesis of trehalose, a sugar required by several different pathogenic fungi. More...
29 Jun 2016
Image: A scanning electron microscope (SEM) image of methicillin-resistant Staphylococcus aureus bacteria (Photo courtesy of the CDC).

Drug Combination Cures MRSA Infection While Preventing Development of Resistance

Treatment with a combination comprising the well-known antibiotic cefdinir and the experimental drug TXA709 cured mice of drug-resistant staphylococcal infections while reducing the development of resistance. More...
23 Jun 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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