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Drug Discovery

Honokiol Prevents Hypertrophy in Mice by Increasing Mitochondrial Sirt3 Activity

The ancient herbal therapy substance honokiol, which is derived from the bark, seed cones, and leaves of trees belonging to the genus Magnolia, has been found in a recent study to have chemical properties that enable it to protect the heart from hypertrophy.  More...
26 Apr 2015

Leaky Calcium Channels Promote Development of Diabetes

Chronic leakage from cellular calcium channels has been linked to a rare type of exercise-induced cardiac arrest and has been shown to cause glucose intolerance, suggesting that it might be involved in the development of type II diabetes.  More...
19 Apr 2015
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease in a mouse model.  More...
13 Apr 2015

Drug Development Acquisition Focuses on Treatment for Movement Disorders

The purchase of a biomedical company that develops drugs for treatment of hyperkinetic movement disorders by one of the world's largest producers of generic drugs is expected to strengthen the generics manufacturer's position in the market for central nervous system condition treatments.  More...
12 Apr 2015
Image: Imaging of burn wounds in mice by confocal microscopy indicates that those treated with FL2 siRNA nanoparticles (far right) experienced collagen deposition and hair follicle formation (Photo courtesy of the Albert Einstein College of Medicine).

Small Interfering RNA Nanoparticles Accelerate Wound Healing in Mouse Model

The time required for wound healing in a mouse model was significantly shortened by treatment with nanoparticles that had been loaded with small interfering RNA that blocked the synthesis of the enzyme fidgetin-like 2.  More...
07 Apr 2015
Image: TEM (transmission electron micrograph) of a mesoporous silica nanoparticle (Photo courtesy of Wikimedia Commons).

Nanoparticle Delivery of Drug Combination Blocks Pancreatic Cancer Growth in Mouse Model

Cancer researchers using two potent chemotherapeutic agents combined in one nanoparticle demonstrated significant improvement in the treatment of pancreatic tumors in a mouse model.  More...
06 Apr 2015
Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening.  More...
22 Mar 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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