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06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016


Image: Microglia (green) surround an amyloid plaque (blue) in the brain of an Alzheimer\'s disease mouse model. Endogenous mouse antibodies (red) associate with microglia in the brains of such mice and boost the microglia\'s ability to degrade plaques (Photo courtesy of Dr. Samuel Marsh, University of California, Irvine).

Neurological Disease Researchers Confirm Link Between Adaptive Immune System and Alzheimer's Disease

Using a novel immunodeficient mouse model that they had created, a team of neurological disease researchers demonstrated the link between the adaptive immune system and the development of Alzheimer's disease.  More...
06 Mar 2016
Image: Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer, which carries receptor-binding and membrane fusion functions (Photo courtesy of Veesler Laboratory, University of Washington).

Structural Analysis Reveals Potential Coronavirus Vaccine Targets

High-resolution analysis of the coronavirus spike glycoprotein has revealed common binding, fusion, and antigenic sites that may be exploited for the development of a broad spectrum vaccine against this family of viruses that includes the human pathogens SARS-CoV and MERS-CoV.  More...
06 Mar 2016
Image: Structure of normal frataxin (FXN) protein (Photo courtesy of Wikimedia Commons).

Synthetic Nucleic Acids Restore Normal Frataxin Levels in Patient-Derived Friedreich's Ataxia Cells

Neurological disease researchers have used synthetic nucleic acid polymers to block the defective FXN gene segment and restore normal levels of frataxin in cells derived from patients with Freidreich's ataxia.  More...
02 Mar 2016
Image: From left to right: Microscopic images comparing the hind leg muscles of normal mice, mice with spinal muscular atrophy, and mice with spinal muscular atrophy that have had the enzyme Jnk3 inhibited. Jnk3 deficiency appears to reduce muscle degeneration (muscle-wasting) and increase muscle growth in mice with the disease (Photo courtesy of the journal Human Molecular Genetics).

Search for Drugs to Treat Spinal Muscular Atrophy Pinpoints Likely Target Enzyme

Neurological disease researchers have identified a target for drugs to treat the hereditary childhood neurodegenerative disorder spinal muscular atrophy.  More...
02 Mar 2016
Image: Binding of a Nutlin to the enzyme mdm2 (shown in red) (Photo courtesy of the BioChemoInformatics Lab, Bologna, Italy).

Unraveling the Molecular Interactions That Enable Nutlin-Class Drugs to Kill Cancer Cells

Loss of the PUMA gene has been shown to protect tumor cells from being killed by the Nutlin class of experimental anticancer drugs.  More...
01 Mar 2016
Image: The photomicrograph shows bird macrophages infected with the fungal pathogen Cryptococcus neoformans (green) (Photo courtesy of the University of Sheffield).

New Insights into the Avian Immune System Explain the Transmission of a Deadly Fungal Infection

A team of British immunologists has discovered how birds, which spread the deadly fungus Cryptococcus neoformans, avoid being killed by the pathogen.  More...
01 Mar 2016
Image: Structure of the intasome protein complex that enables retroviruses to establish permanent infections in their hosts. The intasome hijacks host genomic material, DNA (white) and histones (beige), and irreversibly inserts viral DNA (blue) (Photo courtesy of the Salk Institute for Biological Studies).

Cryoelectron Microscopy Reveals the Ultrastructure of Retroviral Integrase-DNA Complexes

Advanced imaging technology has revealed the ultrastructure of the retrovirus intasome, the protein complex that controls the insertion of viral DNA into the host target cell.  More...
29 Feb 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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