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Bacterial Persistence to Antibiotic Treatment Mediated by HipA Toxin Inhibition of Glutamyl-tRNA-Synthetase Activity

A team of molecular microbiologists has identified the molecular pathway that induces some types of "persistent" bacteria to enter a static or dormant phase when faced with antibiotic treatment.   More...
06 Jan 2014
Image: Colonies of Escherichia coli growing in a laboratory culture (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Deadly Drug-Resistant Strain of Escherichia coli Emerged as a Single Genetic Clone

Molecular microbiologists working with advanced genomic research tools have shown that an extremely virulent and drug-resistant strain of Escherichia coli appeared about 10 years ago following mutations in two genes.  More...
02 Jan 2014
Image: Scanning electron micrograph (SEM) showing numerous clumps of methicillin-resistant Staphylococcus aureus (MRSA) magnified 4,780x (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Antitoxin Vaccine Protects Laboratory Animals Against Staphylococcus Infection

A vaccine comprising a cocktail of superantigens and cytolysins protected rabbits challenged with virulent strains of Staphylococcus aureus while vaccines based on bacterial surface antigens failed to protect the animals or actually increased the severity of the infection.  More...
31 Dec 2013

European Partners to Seek New Approaches for Dealing with Colorectal Cancer

A European research project is directed at finding new diagnostic and therapeutic tools to better find and treat patients with colorectal cancer.  More...
26 Dec 2013
Image: Interlocking DNA bricks create a three-dimensional molecular canvas. Each canvas is composed of many oligonucleotides, or DNA bricks, that have four consecutive eight nucleotide domains. The bricks assemble at right angles to other interlocking bricks, using standard A-T and G-C base pairing (Photo courtesy of Integrated DNA Technologies).

DNA Bricks Have Potential Applications in Several Nanotech and Biotech Fields

Researchers have been exploiting the unique physical properties of DNA in order to develop applications not related to its role in storing genetic information.  More...
25 Dec 2013
Image: A breast tumor (blue) uses leader cells (green) to invade muscle tissue (red) in a mouse (Photo courtesy of Dr. Kevin Cheung, Cell).

Breast Cancer Metastasis Depends on Expression of Leader Cell Protein

Cell biologists have identified a protein that they regard as a potential drug target in a unique class of breast cancer cells that lead the process of metastasis into surrounding tissues.   More...
24 Dec 2013

Pharmacoperone Treatment Restores Proper Function to Misfolded Proteins

A novel class of low molecular weight compounds has been identified that serves as a sort of scaffolding to restore the structure of misfolded proteins and allows the cell to return them to their site of normal activity.  More...
23 Dec 2013

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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