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Image: Micrograph of differentiated muscle fibers (green) with cell nuclei shown in blue (Photo courtesy of Dr. Olivier Pourquié, Harvard University Medical School).

Improved Stem Cell Technology Enables Mass Differentiation of Muscle Fiber Cells

Improvements in stem cell technology have enabled the in vitro differentiation and growth of large numbers of muscle fiber cells, including muscle fibers from a mouse model of Duchenne muscular dystrophy.  More...
16 Aug 2015
Image: The Connex Objet350 3-D printer represents the current state of the art in polymer rapid prototyping systems (Photo courtesy of Stratasys Ltd.).

Neuroscience Research to Benefit from 3-D Printing of Brain-Like Structures

Advanced three-dimensional printing techniques were used to generate a biological construct that incorporated neural cells and mimicked brain cell activities for use in applications ranging from cell behavior studies to improving understanding of brain injuries and neurodegenerative diseases.   More...
12 Aug 2015
Image: Artist\'s conception of an adeno-associated viral capsid in formation by ancestral sequence reconstruction (Photo courtesy of Dr. Eric Zinn, Harvard University Medical School).

Ancient Viruses Built from Computer Models May Improve Gene Therapy Delivery

An advanced computer modeling strategy was used to design ancient forms of adeno-associated viruses, which were then synthesized in the laboratory for use as potential delivery vectors for gene therapy.  More...
11 Aug 2015
Image: A representative image of islets from diabetic mice, which did not receive IL-35 (left) and received IL-35 (right). The brown color represents insulin producing beta cells. New research showed progress in the use of the anti-inflammatory cytokine for treatment of Type I diabetes (Photo courtesy of Dr. Kailash Singh, Uppsala University).

Insufficient Interleukin-35 Leads to Type I Diabetes in Mouse Models

Diabetes researchers have linked onset of the disease to abnormally low levels of the anti-inflammatory cytokine interleukin-35, which is produced by regulatory T cells to suppress autoimmune and inflammatory responses.  More...
10 Aug 2015
Image: Photomicrograph shows emergence of stem cell-derived hepatocytes (Photo courtesy of Dr. Yaakov Nahmias, Hebrew University of Jerusalem, Israel).

Ready Source of Functional Liver Cells Should Boost Drug Development Efforts

Liver function in newborns kicks in only after exposure to certain nutrient factors derived from gut bacteria, and this phenomenon has been used to differentiate pluripotent stem cells into fully functional liver cells.   More...
09 Aug 2015
Image: This is an example of the type of luminescence produced by chemical modification of luciferase. Key: -S, a tube without streptavidin; +S, with streptavidin (Photo courtesy of Dr. Kai Johnsson, Ecole Polytechnique Fédérale de Lausanne).

Multipurpose Biosensors Rely on Luciferase to Light up Target Molecules

A team of Swiss molecular biologists developed a luminescent marker system that sends out a light signal after binding to a specific target molecule.  More...
05 Aug 2015
Image: Mycobacterium tuberculosis (Mtb) uses environmental pH as a cue to adapt its physiology for survival in macrophages. The phoPR two-component regulatory system functions to sense environmental pH and promote Mtb pathogenesis (Photo courtesy of Michigan State University).

Modifying the Macrophage Microenvironment Reduces Tuberculosis Virulence

The virulence of the bacteria causing latent tuberculosis infections can be reduced by modifying the microenvironment inside the macrophages that host the pathogen.  More...
05 Aug 2015

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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