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12 Apr 2017 - 14 Apr 2017
22 Apr 2017 - 26 Apr 2017
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Image: A micrograph of a seminoma, a common germ cell tumor. Tumor cells show a fried egg-like appearance (Photo courtesy of Wikimedia Commons).

Chromosomal Amplifications and Deletions Characterize Germ Line Tumors

Cancer researchers have identified several distinct genomic features underlying the origin of germ cell tumors and that are associated with the chemosensitivity of this type of cancer, as well as changes that occur during the rare progression to chemoresistance. More...
14 Dec 2016
Image: The nCounter system offers a simple, cost-effective way to simultaneously profile hundreds of mRNAs, microRNAs, or DNA targets (Photo courtesy of NanoString).

MicroRNA Regulation Critical for Development of Pediatric Brain Tumors

Cancer researchers have uncovered the critical role played by microRNA regulation in the development of childhood brain tumors. More...
14 Dec 2016
Image: A photomicrograph of NETs following four hours of immunofluorescence staining (Photo courtesy of Madison Floyd, Rada Laboratory, University of Georgia).

Bacterial Motility Is Required to Trigger Neutrophil Immune Response

A team of molecular microbiologists has found that the flagellar motion, which propels Pseudomonas aeruginosa bacteria, was required to generate an immune response, especially the production of neutrophil extracellular traps (NETs). More...
13 Dec 2016
Image: A structural model of the protein encoded by the PTEN gene (Photo courtesy of Wikimedia Commons).

Anemia Proteins Function Cooperatively with PTEN Tumor Suppressor

A recently discovered link between the rare childhood genetic syndrome Fanconi anemia and the PTEN tumor suppressor gene could lead to the development of improved treatment options for cancer patients with certain types of PTEN mutations. More...
13 Dec 2016
Image: Photomicrographs of the engineered cells (nuclei in blue) with HIF-1 visualized (in red). In the left hand panel, cells are in hypoxia but no doxycycline is present, therefore HIF-1 remains active (red dots). In the right hand panel, the cells are grown in hypoxia and in the presence of doxycycline, therefore the cyclic peptide inhibitor is produced and HIF-1 is inhibited, as demonstrated by the absence of the red dots (Photo courtesy of the University of Southampton).

Gene Therapy Prevents Cancer Cells from Surviving in Hypoxic Environment

Gene therapy techniques were used to insert a peptide into cultures of human cancer cells that blocked their ability to use the enzyme Hypoxia-inducible factor-1, a heterodimeric transcription factor that enables cell survival under low oxygen conditions by altering the transcription of over 300 genes. More...
08 Dec 2016
Image: A neuron in culture was transduced with a virus that expresses a green fluorescent protein and an inhibitory RNA that causes loss of the DENND5A protein. The neurons where then stained with a marker of neuronal processes in red (Photo courtesy of Peter McPherson Laboratory, Montreal Neurological Institute, McGill University).

Loss of Neuronal Enzyme Underlies Rare Childhood Epileptic Encephalopathy

A recessive mutation causing loss of an enzyme required for neuronal development was shown to underlie a rare form of childhood epileptic encephalopathy. More...
08 Dec 2016
Image: Neutralizing antibodies bind to a structure known as the astrovirus capsid spike domain, which projects from the surface of astrovirus particles. By binding to the spike domain, the antibodies block the virus\'s ability to attach to and infect human cells (Photo courtesy of Walter Bogdanoff, University of California, Santa Cruz).

Crystal Structure Reveals How Neutralizing Antibody Blocks Astrovirus Infection

A team of molecular virologists used X-ray crystallography to establish how a neutralizing antibody bound to the surface of the gastroenteritis-causing astrovirus and blocked its entry into uninfected cells. More...
08 Dec 2016

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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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