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10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016


Biochemists Present First 3D Crystal Structure of a Nonribosomal Peptide Synthetase

A team of Canadian biochemists has presented a series of three-dimensional X-ray crystallography structures of the initiation module of the antibiotic-producing nonribosomal peptide synthetase megaenzyme, linear gramicidin synthetase.  More...
03 Feb 2016
Image: Diagram of a viral vectored vaccine built using the SpyCatcher/ Tag combination. SpyCatcher (dark blue) is fused to the virus-like particle (purple). SpyTag (light blue) is fused to antigens (yellow). When SpyTag forms an isopeptide bond with SpyCatcher (diagram right), the antigens are attached to the virus-like particle (Photo courtesy of the University of Oxford).

Tag Team Combination Simplifies Vaccine Development

Vaccine development is simplified when a highly immunogenic virus-like particle carrier is tagged with a genetically-encoded protein designed to spontaneously form a covalent bond to its antigen-labeled peptide-partner.  More...
03 Feb 2016
Image: Molecular model of coagulation Factor VII (Photo courtesy of Wikimedia Commons).

Potential of Gene Therapy for Treating Hemophilia Demonstrated in Dog Model

A gene therapy approach was shown to cure a form of hemophilia caused by deficiency of the Factor VII coagulation protein in a dog model system.  More...
02 Feb 2016
Image: Green fluorescent dyes shown in this micrograph mark the presence of the glucose transporter, GLUT1, on the surface of lymphoblastoid cells which go on to form the lymphomas caused by Epstein-Barr virus. GLUT1 appears here because these cells have been taken over by the virus, which increases demand for more glucose to continue its infectious path (Photo courtesy of Dr. Amy Hafez, Duke University).

Prolonged Cell Division Arrest Prevents Development of Cancers Caused by Epstein-Barr Virus

A mechanism has been identified that helps explain why despite most people having been infected with Epstein-Barr virus, very few develop the lymphomas and other cancers the virus can cause.  More...
02 Feb 2016
Image: Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules sequestered inside. Various targeting ligands may be attached to their exterior in order to allow their surface-attachment and accumulation in pathological areas (Photo courtesy of Wikimedia Commons).

Photoactivated Nanoparticles Block Pancreatic Cancer Growth and Metastasis in Mouse Models

A nanoparticle delivery system was used for the safe transport a photodynamic therapy agent together with a highly toxic anti-cancer drug for the pinpoint treatment of pancreatic cancer.  More...
01 Feb 2016
Image: Under very-high magnification, this digitally-colorized scanning electron micrograph (SEM) depicts a number of filamentous Ebolavirus particles (red) that had budded from the surface of a VERO cell (brown) of the African green monkey kidney epithelial cell line (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Antibodies Isolated from Ebola Survivors Recognize Wide Range of Ebolavirus Species

A team of molecular virologists has isolated human monoclonal antibodies from Ebola survivors that were able to neutralize multiple species of the virus and protect guinea pigs from challenge with the live virus.  More...
01 Feb 2016
Image: A view of the Cas9 protein (red and blue) bound to a double strand of DNA (purple and grey). After both strands are cut, one DNA strand (purple dots) is free and able to bind with a piece of DNA to be inserted at the break. This behavior can be utilized to significantly boost the efficiency of gene editing (Photo courtesy of Dr. Christopher Richardson, University of California, Berkeley).

Researchers Co-opt Slow DNA Release to Improve Accuracy of CRISPR/Cas9 Genome Editing

A careful study of the interaction of the Cas9 enzyme with target DNA has enabled genomics researchers to significantly improve the success rate of CRISPR-Cas9 gene editing.   More...
31 Jan 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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