Features Partner Sites Information LinkXpress
Sign In
Advertise with Us


05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017


Image: The XLRS is caused by mutations in the retinal protein retinoschisin. The protein plays a crucial role in the cellular organization of the retina, assembling itself to form paired octameric (consisting of eight retinoschisin) rings. The rings each resemble an eight-bladed propeller (Photo courtesy of the University of Manchester).

Report Describes Mechanism Underlying Genetic Eye Disease

The molecular mechanism responsible for the genetic eye disease X-linked Retinoschisis (XLRS), which leads to a type of macular degeneration in which the inner layers of the retina split causing severe loss of vision and gradual blindness, was described in a recent publication. More...
15 Nov 2016
Image: Schematic of a gateway in the nuclear membrane, known as the nuclear pore complex (NPC), and the proteins (shown as spheres) involved in transport and quality control of mRNAs (shown in red). A combination of a multitude of protein-protein interactions enables the cell to distinguish and keep aberrant mRNAs from exiting the nucleus (Photo courtesy of Mohammad Soheilypour, Berkeley National Laboratory).

Messenger RNA Quality Control Mechanism Explained

Genomics researchers have described a mechanism that explains how molecules of messenger RNA (mRNA) are checked for accuracy before being released from the nucleus into the cytoplasm. More...
15 Nov 2016
Image: The yeast model Saccharomyces cerevisiae was used to help researchers understand the role of genetic suppression in debilitating diseases (Photo courtesy of Getty Images).

Disease Genes Effect May Be Overcome by Other Gene Mutations

A first-of-its-kind study, performed in the model yeast Saccharomyces cerevisiae, shows how “bad genes aren’t always bad news” in that the disease-causing effects of mutations in certain genes can be overcome by suppression-mutations in certain other genes. The study opens a new way for better understanding how some people naturally stay healthy despite having disease-causing mutations, and potentially a new path to better diagnostics and therapies of genetic disorders. More...
15 Nov 2016
Image: When the mouse gene Rabep2 is deficient, the number and diameter of collateral blood vessels are reduced by 50-60%, and the amount of brain tissue that dies after stroke is more than doubled. The human version of Rabep2 is likely to have a comparable function (Image courtesy of the Faber Lab, University of North Carolina School of Medicine).

Vascular Development Gene Helps Protect Against Stroke Damage

Using CRISPR gene-editing technology and genetically engineered mice, scientists have discovered that a “collateral vessels” gene, Rabep2, protects against stroke damage. Variants of the human version of the gene may help explain why people differ so much in their ability to survive artery blockages. More...
15 Nov 2016
Image: The structural model of the SIRT2 protein (Photo courtesy of Wikimedia Commons).

Researchers Describe Aggressive Breast Cancer Molecular Mechanism

Cancer researchers have found that SIRT2, a member of the sirtuin family of enzymes, stabilizes Slug, a transcription factor that promotes the development, growth, and spread of basal-like breast cancer. More...
11 Nov 2016
Image: The RNA-protein complex Sm/RNP, which is released from dead cells, stimulates B-cells capable of producing anti-Sm/RNP antibody (anti-Sm/RNP B lymphocytes). The resulting anti-Sm/RNP antibody induces development of systemic lupus erythematosus (SLE) by forming immune complexes together with Sm/RNP (Photo courtesy of the Department of Immunology, Tokyo Medical and Dental University).

Protein Identified Prevents Systemic Lupus Erythematosus

A protein has been identified that functions to prevent the immune system from generating the autoimmune response responsible for lupus erythematosus, a disease associated with inflammation of various organs including kidney, brain, skin, heart, and lung. More...
11 Nov 2016
Image: Immunofluorescence staining for PARP9 (red) and PARP14 (green) with nuclei shown in blue (Photo courtesy of Dr. Masanori Aikawa, Brigham and Women\'s Hospital).

Two PARP Family Enzymes Cross-Regulate Macrophage Activation

Two of the PARP (poly(ADP-ribose) polymerase) family of enzymes have been identified as being key regulators of the type of macrophage activation that has been linked to development of atherosclerosis. More...
09 Nov 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
Copyright © 2000-2017 Globetech Media. All rights reserved.