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Genomics/Proteomics

Image: Micrograph showing amyloid-beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).

Cathepsin B Inhibitors Ease Alzheimer's Symptoms by Blocking Amyloid Plaque Formation

Neurobiologists studying the molecular processes underlying Alzheimer's disease have identified the mechanism that explains how inhibition of cathepsin B activity blocks formation of the toxic amyloid-beta peptides that characterize the disease.  More...
27 Mar 2014
Image: Schematic diagram of the Epstein-Barr virus (Photo courtesy of Wikimedia Commons).

Viral Oncogenes Short-Circuit Critical DNA Repair Mechanisms

A team of molecular biologists has used the oncogenic Epstein-Barr virus to determine how DNA repair mechanisms become compromised to allow cells with damaged genomes to divide and proliferate.  More...
27 Mar 2014
Image: LIMD2, a protein that can drive metastasis (Photo courtesy of the Wistar Institute).

Metastasis Drug Target Identified

Cancer researchers have identified a protein that is critically linked to processes leading to metastasis, the deadly spread of cancer away from the primary tumor.  More...
26 Mar 2014
Image: Insulin-expressing cells (red) arising within the intestinal crypts (green) of a mouse that received three beta-cell “reprogramming factors” (Photo courtesy of Dr. Ben Stanger, University of Pennsylvania).

Transformed Intestinal Cells Produce Insulin in Novel Diabetes Treatment

A population of intestinal cells was found to be capable of morphing into insulin-producing beta-cells, which may pave the way a novel treatment for diabetes.  More...
25 Mar 2014

ATP-Triggered Nanoparticles Effectively Kill Breast Cancer Cells in Mouse Model

A recent paper describes novel nanoparticles that transport toxic anticancer drugs specifically to tumor cells where they are engulfed and induced to release their cargo by the high intracellular concentration of adenosine-5'-triphosphate.  More...
25 Mar 2014

Six Months of British Cancer Research Organization’s Genetic Data Decoded in One Month by Smartphone Gamers

In just one month, “citizen scientists” have studied DNA data that would have taken a scientist six months to analyze by eye by playing a new smartphone game Play to Cure: Genes in Space.   More...
23 Mar 2014
Image: In the heart muscle cell above, the arrows show an early sign of replication (Photo courtesy of Johns Hopkins University).

Identification of Rare Mutation May Lead to Heart Repair Gene Therapy

Identification of the mutation responsible for an exceedingly rare type of heart defect in infants may pave the way for a gene therapy approach for regenerating adult heart tissue damaged by heart attack or disease. More...
17 Mar 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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