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Image: An artistic rendering of the Zika virus structure (Photo courtesy of Dr. Guntur Fibriansah, Duke-NUS Medical School).

High Resolution Structure of Zika virus Expected to Aid Vaccine Development

A team of molecular virologists used advanced cryo-electron microscopy techniques to establish a high-resolution structure for the Zika virus, a formerly neglected pathogen that has recently been associated with microcephaly in fetuses and with Guillian–Barré syndrome in adults. More...
04 May 2016

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. More...
04 May 2016

Cardiac Researchers Use Stem Cells to Generate Functional Heart Muscle

Stem cell researchers have developed a new technique to form micro-scale arrays of engineered heart muscle (EHM) from fewer than 10,000 starter cells without requirement for adherence features or extracellular matrix (ECM). More...
03 May 2016

Cells Loaded with Prodrug-Containing Microparticles Selectively Destroy Prostate Cancer Tumors

A novel approach to treating metastatic prostate cancer with minimal adverse side effects is based on cellular transport of a harmless prodrug that is activated and becomes toxic only in the vicinity of the tumor microenvironment. More...
02 May 2016
Image: A confocal microscopy image of human fibroblasts derived from embryonic stem cells. The nuclei appear in blue, while smaller and more numerous mitochondria appear in red (Photo courtesy of Dr. Shoukhrat Mitalipov, Oregon Health & Science University).

Stem Cells Derived from Older Individuals May Carry Unsafe Mitochondrial DNA Mutations

Induced pluripotent stem cells (iPSCs) derived from the skin fibroblasts of older individuals have a likelihood of harboring mitochondrial DNA mutations, which may render them unfit for clinical applications. More...
29 Apr 2016
Image: A cross-section of injured mouse muscle tissue, with healthy tissue in pink and scar tissue shown in purple. Both mice genetically lack T-cells; the mouse on the left was injected with T-cells that became type II helper T-cells and aided healing (Photo courtesy of Dr. Kenneth Estrellas, Johns Hopkins University).

Biomaterial Scaffolds Boost Interleukin Production to Promote Wound Healing

The improved wound healing promoted by use of "biomaterial" scaffolds was shown to be due to activation of the immune system's T helper II pathway with a subsequent increase in production of interleukins. More...
29 Apr 2016
Image: Drop-inoculation of Saccharomyces cerevisiae mutants on an agar plate. The assay compares the viability of different yeast mutants (Photo courtesy of Wikimedia Commons).

Defective Genome Instability Suppressing Genes May Cause Some Types of Cancer

Cancer researchers reported in a recent study that defects in the expression of genes that suppress gross chromosomal rearrangements (GCRs) were linked to more than 93% of the ovarian and 66% of the colorectal cancer cases they had examined. More...
28 Apr 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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