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11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017
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Genomics/Proteomics

Image: A molecular model of the UCHL3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3) enzyme, a critical regulator of double-strand DNA repair (Photo courtesy of Wikimedia Commons).

Enzyme Identified Promotes Cancer Development by Mishandling Repair of DNA Breaks

Cancer researchers have identified an enzyme linked to defective repair of damaged DNA, which is a mechanism that prevents cell death and mediates transformation into a cancerous state. More...
22 Dec 2016
Image: A micrograph showing invasive adenocarcinoma (the most common type of colorectal cancer). The cancerous cells are seen in the center and at the bottom right of the image (blue). Near normal colon-lining cells are seen at the top right of the image (Photo courtesy of Wikimedia Commons).

Mechanism Explains How Colon Cancer Suppressor Protein Works

The intracellular protein NLRC3 (NLR family CARD domain containing 3) blocks growth of colon cancer by suppressing activation of mTOR (Mechanistic target of rapamycin) signaling pathways. More...
22 Dec 2016
Image: A molecular model of the argininosuccinate synthetase 1 (ASS1) protein (Photo courtesy of Wikimedia Commons).

Novel Approach to Bladder Cancer Chemotherapy Based on Arginine Depletion

Studies conducted on arginine-dependent bladder cancer cell cultures and mouse xenografts revealed that this cancer is highly susceptible to treatment with a drug compound comprising the enzyme arginine deiminase (ADI) conjugated to polyethylene glycol (PEG). More...
21 Dec 2016
Image: A molecule model of a CRISPR (clustered regularly interspaced short palindromic repeats) and a DNA fragment from E. coli (Photo courtesy of Wikimedia Commons).

Anti-CRISPR Proteins Increase Safety and Accuracy of Gene Editing

A set of naturally occurring proteins has been identified that specifically inhibits the action of the CRISP/Cas9 molecular genome-editing complex and thereby greatly increases its accuracy as a tool for manipulating gene expression. More...
21 Dec 2016
Image: A structural model of Bfl-1 (light blue ribbon with yellow stick representing a sulfur atom) in complex with the inhibitor 130G4 (green ribbon with red, oxygen, and blue, nitrogen, sticks). The bond between the Bfl-1 sulfur atom (yellow) and 130G4 is highlighted by a magenta stick (Photo courtesy of Pellecchia laboratory, University of California, Riverside).

Development of Anti-Cancer Drugs May Overlook Compounds Useful for Humans

A large proportion of cancer research is done with mouse models; however a recent paper suggested that differences between the mouse and human genomes may lead to promising approaches to curing the disease in humans being overlooked. More...
21 Dec 2016
Image: Cells that express exon 6-truncated p53 protein exhibit structural features that reflect their reprogramming away from stability and toward proliferation and metastasis. This was apparent when comparing cells that do not express the truncated form of the protein (left column) with those that do (right column). The two images at the top are composites, with blue indicating DNA (i.e., cell nuclei); and green and red corresponding, respectively, with the proteins actin and e-cadherin. In the cells reprogrammed by truncated p53 proteins, actin fibers (middle image) show stress, while the signal from e-cadherin \"glue\" drops out altogether (bottom image). These cells are much more likely to break away from tissue and travel in the body (Photo courtesy of Sordella Laboratory, Cold Spring Harbor Laboratory).

Shortened p53 Protein Promotes Tumor Growth by Modulating Mitochondrial Function

A shortened version of the p53 protein - caused by a mutation in the TP53 tumor suppressor gene – has been found to promote rather than impede tumor growth. More...
20 Dec 2016
Image: A crystal structure of the PodA protein complex with three molecules of 1-hydroxyphenazine, the reaction product, bound in the active sites (Photo courtesy of Kyle Costa, California Institute of Technology).

Enzymatic Degradation of Pyocyanin Blocks Pseudomonas Biofilm Formation

An enzyme isolated from the soil bacterium Mycobacterium fortuitum was found to prevent biofilm formation by the aggressively pathogenic Gram-negative bacterium Pseudomonas aeruginosa. More...
20 Dec 2016

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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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