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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017


Image: Researchers have created a tissue-engineered model of the lung and trachea to help study disease processes (Photo courtesy of the Children’s Hospital Los Angeles).

Lung and Tracheal Tissue Expected to Aid Respiratory Disease Research

By modifying a technique for growing cultured intestinal tissue, researchers have developed a tissue-engineered model of the lung and trachea, which contains the diverse cell types present in the human respiratory tract. More...
25 Nov 2016
Image: The DNA barcode library (Photo courtesy of Shutterstock).

DNA-barcode Labeled Nanoparticles Trace Drug Susceptibility

Novel DNA-barcoded nanoparticles loaded with anti-cancer drugs were used to screen for susceptibility at the cellular level as a first step in the development of personalized cancer therapy. More...
23 Nov 2016
Image: Photomicrographs of fibroblasts from patients with Huntington\'s disease marked with fluorescence. Top row: the cells have accumulated mutant RNA. Bottom row: the cells no longer show blocked RNA accumulations (Photo courtesy of the Center for Genomic Regulation).

Blocking Mutant RNA Cures Huntington's Disease in Mouse Model

Researchers seeking ways to treat Huntington's disease have suggested going after the messenger RNA that mediates between the mutant gene that causes the disease and the toxic protein that causes the neurological damage that characterizes it. More...
23 Nov 2016
Image: A micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons).

Mitochondrial Protein Linked to Development of Prostate Cancer

Results obtained from experiments with genetically engineered mouse models revealed a direct link between the mitochondrial chaperone protein, TRAP1 (TNF receptor associated protein 1) and the development of prostate cancer. More...
23 Nov 2016
Image: Two adjacent sections of a mouse breast tumor. Tissue at left is stained so that normal blood vessels can be seen (black arrow). Extending from these vessels are blood filled channels (green arrows). On the right, the tissue is stained for a fluorescent protein expressed by the tumor cells. Here it is seen that blood-filled channels are actually formed by tumor cells in a process known as vascular mimicry (Photo courtesy of Cold Spring Harbor Laboratory).

Macrophages Form Vascular Mimicry Channels to Supply Growing Tumors

A potential new therapeutic approach to block cancer development is based on the finding that macrophages form primitive non-endothelial “vessels” or vascular mimicry channels that help supply growing tumors with oxygen and nutrients. More...
22 Nov 2016
Image: An artist\'s concept of a domain-swapped T-cell receptor (TCR) engaging a peptide presented by a tumor cell on a major histocompatibility complex (MHC) molecule. In TCR gene therapy, genes encoding a tumor-specific TCR are introduced to a patient\'s T-cells, retargeting them to attack cancer cells. Swapping the constant domains between the alpha and beta chains of the tumor-specific TCR prevents these chains from mispairing with the TCR chains resident to each T-cell, which can result in autoimmune disease (Photo courtesy of the California Institute of Technology).

Modified T-Cells Attack Tumors without Triggering Autoimmune Disease

A team of molecular immunologists has devised a method to direct T-cells to recognize and fight cancer cells without risk of the modified cells attacking normal tissues and thereby triggering autoimmune disease. More...
22 Nov 2016
Image: A digitally colorized transmission electron micrograph (TEM) of Zika virus. Virus particles, here colored red, are 40 nanometers in diameter, with an outer envelope, and an inner dense core (Photo courtesy of the CDC).

DNA-based Zika Vaccine Demonstrates Potential in Animal Models

A DNA-based vaccine has shown promise in protecting animal models against infection and brain damage caused by the Zika virus. More...
22 Nov 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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