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Monoclonal Antibody Blocks Development of Type I Diabetes in Mouse Model

Monoclonal antibody treatment prevented development of type I diabetes in a mouse model of the disease.   More...
17 Jun 2015
Image: In meso in situ serial crystallography (IMISX) equipment that was used to quickly and accurately provide detailed blueprints of protein structure (Photo courtesy of Dr. Martin Caffrey, Trinity College Dublin).

Structure of Integral Membrane Proteins Readily Solved Using an Alternative In Meso In Situ Serial Crystallography Technique

A recent paper discussed the benefits of using synthetic cyclic olefin copolymer plates to replace glass as the base for generation and growth of crystals of membrane and soluble proteins for high-resolution X-ray crystallographic structure determination.   More...
16 Jun 2015
Image: Electron micrograph of bacteriophages attached to a bacterial cell. Phages were used to deliver programmable DNA nuclease to reverse antibiotic resistance and eliminate the transfer of resistance between strains (Photo courtesy of Wikimedia Commons).

Novel Phage Treatment Restores Bacterial Sensitivity to Antibiotics

A novel phage-based genetic strategy has been developed that aims to sensitize bacteria to antibiotics while selectively killing antibiotic-resistant strains.   More...
15 Jun 2015

New Version of Old Drug Shows Promise for Treating Drug-Resistant Tuberculosis

A team of molecular microbiologists has determined the mechanism by which theStreptomyces-derived antibiotic griselimycin blocks the growth of Mycobacterium tuberculosis, the bacterium responsible for causing more than eight million cases of tuberculosis annually on a worldwide basis.  More...
15 Jun 2015
Image: Scanning electron micrograph (20,000x) of a strain of Staphylococcus aureus (Photo courtesy of the CDC - [US] Centers for Disease Control and Prevention).

Chronic Exposure to Bacterial Superantigens Induces Diabetes-Like Symptoms in Rabbit Model

Researchers working with a rabbit model have shown that chronic exposure to the toxin produced by the bacterium Staphylococcus aureus can induce metabolic changes similar to those seen in type II diabetes.  More...
14 Jun 2015
Image: Researchers using RApidCaP, a mouse model of human metastatic prostate cancer, have identified an immune system marker that may help to distinguish patients who will and will not respond to hormone therapy. That marker is IL-6, an immune system component whose presence is indicated in brown patches in the image at left, in a section of lung tissue (blue) colonized by prostate cancer cells. The middle image of the same section of lung tissue indicates activation of STAT3, a protein that is the downstream target of IL-6 signaling. The image at right of the same tissue section demonstrates the presence of PCNA in the invading prostate cells, a marker of metastasis (Photo courtesy of Trotman Laboratory, Cold Spring Harbor Laboratory).

Mouse Model Demonstrates Importance of Interleukin-6 to Spread of Prostate Cancer

Cancer researchers used a recently developed mouse model of metastatic prostate cancer to determine what factors are involved in the processes that trigger cell proliferation and drive progression of the disease.  More...
14 Jun 2015
Image: Coronary vasculature in zebrafish (Photo courtesy of Children\'s Hospital, Los Angeles).

Zebrafish Embryo Model Helps Explain How Coronary Blood Vessels Develop

Developmental biologists have used a zebrafish embryo model to study the factors that control the formation and maturation of coronary blood vessels.  More...
10 Jun 2015

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.


17 Oct 2015 - 21 Oct 2015
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