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06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016


Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible costimulator ICOS via the kinase TBK1 (TANK-binding kinase 1). More...
19 May 2016
Image: A photomicrograph showing multiple myeloma cells in the bone marrow (Photo courtesy of the University of Miami School of Medicine).

New Multiple Myeloma Mouse Model Should Advance Drug Development Efforts

A recently developed multiple myeloma mouse model is expected to aid in understanding the pathology of the disease and serve as a platform for preclinical testing of potential therapeutic agents. More...
18 May 2016
Image: Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis to other organs, pointing to a potential new treatment. Findings showed a higher number of metastatic lesions in organs of untreated and treated mice, shown at top and bottom, respectively (Photo courtesy of Dr. Junjie Li, Purdue University).

Inhibition of Cholesterol Esterification Suppresses Growth of Pancreatic Cancer Cells

A team of cancer researchers has suggested that controlling cholesterol metabolism within tumor cells represents a novel approach towards treating the disease. More...
18 May 2016
Image: A structural model of the cathepsin S (CTSS) protein (Photo courtesy of Wikimedia Commons).

Protein Imbalance Linked to Presence of Biomarker in Tears of Sjögren’s Syndrome Patients

Increased expression of cathepsin S (CTSS) activity has emerged as a unique biomarker in the tears of Sjögren’s syndrome (SS) patients. More...
17 May 2016
Image: Molecular structure of factor H bound to C3b. In order to avoid self-attack, regulatory proteins such as factor H bind with C3b, a central component of the enzyme C3 convertase, to help the immune system recognize the body’s own tissue and keep complement in check (Photo courtesy of the University of Pennsylvania School of Medicine).

Antibodies against Complement Factor H Selectively Destroy Tumor Cells

Cancer researchers have identified and produced a monoclonal antibody that destroys tumor cells by blocking the activity of the protective protein complement factor H (CFH). More...
17 May 2016
Image: After treatment with riluzole, the brains of old rats showed more of a transporter molecule that removes excess glutamate, (green fluorescence, right) as compared to untreated rats (left) (Photo courtesy of The Rockefeller University).

Glutamate Modulator Reverses Genetic Expressions of Aging and Alzheimer's Diease in Rodent Model

Neurological disease researchers have found that the glutamate modulator riluzole reversed gene expression profiles caused by age and Alzheimer’s disease (AD) in a rat AD model. More...
16 May 2016
Image: Aggregated SOD1 protein can be seen as green dots in the cell fluid of a motor neuron in the spinal cord of an ALS patient. The red area is the nerve cell nucleus (Photo courtesy of Peter Andersen, Umeå University).

Mutant Protein Aggregates Drive Progression of ALS in Mouse Model

Researchers working with a mouse model of amyotrophic lateral sclerosis (ALS) have demonstrated that aggregates of mutated superoxide dismutase 1 (SOD1) can propagate the disease by progressing through nerve cells along the animal's spinal cord. More...
16 May 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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