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Genomics/Proteomics

Image: A fluorescent microscope image of liver cells and the chemical structure of glutamine (Photo courtesy of Dr. Kristina Schoonjans, Ecole Polytechnique Fédérale de Lausanne).

Disrupting Glutamine Metabolism Slows Liver Cancer Growth

Cancer researchers used a line of genetically engineered mice to demonstrate the dependency of liver cancer cells on the amino acid glutamine as their primary energy source. More...
23 Jun 2016
Image: A micrograph showing immune cells (green) attacking tumor cells (red) (Photo courtesy of Dr. Michele De Palma, Ecole Polytechnique Fédérale de Lausanne).

Blocking MicroRNA Synthesis Reverses Behavior of Tumor-Associated Macrophages

Preventing synthesis of microRNAs in compromised tumor associated macrophages (TAMs) reprograms these cells from being tumor supporting to being tumor suppressing. More...
22 Jun 2016
Image: The molecular structure of a peptoid helix (Photo courtesy of The Peptoid Summit).

Peptoids that Mimic Antigen Shapes May Lead to a New Generation of Diagnostic Tests

A novel immunoassay for detection of HIV is based on anti-HIV antibodies that recognize specific three-dimensional shapes in a massive, randomly generated library of synthetic peptoid molecules. More...
22 Jun 2016
Image: Positive alpha-synuclein staining of a Lewy body from a patient who had Parkinson\'s disease (Photo courtesy of Wikimedia Commons).

Toxic Clumps of Alpha-Synuclein Disrupt Function in Parkinson's Disease Neurons

Neurodegenerative disease researchers have found that some symptoms of Parkinson's disease (PD) are caused by the deleterious effect of toxic clumps of alpha-synuclein on mitochondrial function. More...
21 Jun 2016
Image: Multipotent stem cells, responsible for the development of the prostate (Photo courtesy of Dr. C. Blanpain, Université libre de Bruxelles).

Pair of Enhanced Techniques Developed for Stem Cell Lineage Tracing

European cell biologists have developed a pair of methods for the precise assessment of the multipotent or unipotent fate of stem cells. More...
21 Jun 2016
Image: When packaged inside tobacco mosaic virus nanoparticles, phenanthriplatin is delivered to tumors, where it was shown to be more effective in vivo than an approved platin (Photo courtesy of Case Western Reserve University).

Tobacco Mosaic Virus Nanoparticle Delivery System Increases Potency of Experimental Anticancer Drug

A candidate anticancer drug was found to be considerably more potent than standard treatments and this potency was further increased in a mouse model when the drug was delivered by a tobacco mosaic virus (TMV)-based transport system. More...
20 Jun 2016
Image: Molecular model of a hydrogel consisting of custom peptide fibers with spaces - \"missing teeth\" - that can trap and deliver hydrophobic small-molecule drugs (Photo courtesy of I-Che Li, Rice University).

Custom Designed Peptides Transport Hydrophobic Drug Compounds

A bioengineering team has designed a novel class of drug-delivery peptides that coalesce into a hydrogel capable of transporting hydrophobic compounds within the hydrophobic cores of the peptide nanofibers. More...
20 Jun 2016


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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