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Image: The photomicrograph shows the head of a mouse embryo in which the pericytes are visible as blue dots along the blood vessel (Photo courtesy of the University of Gothenburg).

Genetically Engineered Mouse Model Reveals Key to Formation of the Blood-Brain Barrier

Use of a mouse model that had been genetically engineered to lack the gene that encodes the forkhead transcription factor Foxf2 has helped to explain how pericytes, cells that line the capillaries, form and maintain the blood-brain barrier.  More...
05 Jul 2015
Image: Cholesterol–shown here in hamster ovary cells—is a building block of steroid hormones that trigger puberty and support pregnancy (Photo courtesy of Dr. D. Ory, Washington University School of Medicine).

Cholesterol Trafficking in the Mouse Embryo Is Regulated by a snoRNA

Cellular cholesterol trafficking in mouse embryos was found to be regulated by U17 snoRNA.   More...
01 Jul 2015
Image: Cells stained orange to illuminate the endoplasmic reticulum and Golgi apparatus, the parts of the cell where the enzyme Fam20C might phosphorylate other proteins (Photo courtesy of University of California, San Diego).

Extracellular Protein Kinase Interacts with Broad Spectrum of Potential Substrates

A single enzyme, Fam20C, has been linked to the phosphorylation of more than 100 different proteins representing nearly 90% of all phosphorylated secreted proteins.  More...
01 Jul 2015
Image: A colorized scanning electron micrograph (SEM) of a T lymphocyte. Regulatory T-cells (Treg cells) are critically important for preventing the body’s immune response from going overboard and causing autoimmune disease (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Hypoxia Factors Contribute to Maintenance of Regulatory T-cell Function

A team of cell biologists has identified a molecular pathway that maintains the stability and function of regulatory T-cells, which are components of the immune system that suppress immune responses of other cells and act as an important “self-check” built into the immune system to prevent excessive reactions.  More...
29 Jun 2015
Image: Three-dimensional model of chromatin (Photo courtesy of Dr. Beat Fierze, Ecole Polytechnique Fédérale de Lausanne).

Real-Time Studies Show How an Effector Protein Regulates Cellular Gene Expression

A series of elegant single molecule experiments have revealed in real-time how the effector protein HP1alpha interacts with chromatin in its target histones to regulate gene expression.  More...
29 Jun 2015
Image: The stomach bacterium Helicobacter pylori changes the activity of genes in gastric cells (Photo courtesy of Max Planck Institute for Infection Biology).

Suppression of DNA Repair by H. pylori Paves the Way for Development of Gastric Cancer

A team of molecular microbiologists has established what they believe to be the definitive link between Helicobacter pylori infection and the development of gastric cancer.  More...
28 Jun 2015

New Microarray to Boost Developmental Delay Research

A new tool for studying the genetic causes of developmental delay was unveiled at a recent human genetics conference.  More...
23 Jun 2015

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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