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Dendrimer-Transported MicroRNA Shown Effective in Treating Mice with Late-Stage Liver Cancer

Cancer researchers have used nanocarriers called dendrimers to transport a specific tumor growth-inhibiting microRNA to the livers of mice with late-stage liver cancer.  More...
10 Feb 2016

Annatto Component Prevents UV Damage and Prevents Skin Cancer in Mouse Model

The apocarotenoid compound bixin is a widely consumed food additive that was shown in a recent paper to have potent antioxidant properties, which prevented the formation of cancer cells and skin damage from UV radiation in a mouse model.  More...
09 Feb 2016
Image: Copper, zinc superoxide dismutase (Cu Zn SOD) is essential to life, but when damaged can become toxic (Photo courtesy of Oregon State University).

Novel Copper Therapy Cures ALS Mouse Model

Selective delivery of copper to the central nervous system effectively treats the motor neuron disease amyotrophic lateral sclerosis in the most widely used mouse model of the disorder.   More...
09 Feb 2016
Image: Top: Overview of the structure of T-STAR STAR domain in complex with AUUAAA RNA. Bottom left: close up view of the specific recognition of the RNA. Bottom right: close up view of the KH dimerization interface (Photo courtesy of the University of Leicester).

Atomic Structures of Alternative Splicing Regulator Proteins May Lead to New Anticancer Drugs

A detailed structural analysis of two RNA-binding proteins that regulate alternate splicing of gene expression, which can lead to various types of cancer, is expected to aid in the development of drugs to suppress this activity.  More...
08 Feb 2016
Image: Biomedical engineering researchers have developed a technique for creating microscopic “depots” for trapping drugs inside cancer tumors. In an animal model, these drug depots were more effective at shrinking tumors than the use of the same drugs without the depots (Photo courtesy of Quanyin Hu, University of North Carolina).

Nanocarriers Deploy Enzymes for Targeted Delivery of Anticancer Drugs

A newly devised nanocarrier delivery system transports a combination of anticancer and anti-angiogenesis drugs to the site of a tumor where the acidic environment releases them to damage the cancer cells and deprive them of nutrients by blocking creation of new blood vessels.   More...
08 Feb 2016
Image: Skin cells from a patient with X-linked retinitis pigmentosa were transformed into induced pluripotent stem cells and the blindness-causing point mutation in the RPGR gene was corrected using CRISPR/Cas9 (Photo courtesy of Dr. Vinit Mahajan, University of Iowa).

Gene Editing Technique Corrects Patient-Derived Stem Cell Mutation

The relatively new CRISPR/Cas9 gene editing technique was used to correct a mutation in the genome of stem cells derived from skin cells taken from patients with the hereditary optical disorder retinitis pigmentosa.  More...
08 Feb 2016

First-Ever Gene Identified with Biological Origin of Schizophrenia

In a landmark study, researchers have identified mutants of the complement component 4 gene that are strongly associated with the risk of developing schizophrenia.   More...
07 Feb 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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