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Genomics/Proteomics

Image: The presence of p45 (green staining) and p75 (red staining) indicates that motor neurons increase both p45 and p75 expression after sciatic nerve injury in an animal (Photo courtesy of the Salk Institute for Biological Studies).

Blocking Nerve Growth Factor Receptor Enables Human Nervous System Regeneration

The mystery of why the human nervous system is unable to regenerate may have been at least partially solved with the identification of a protein called p75 that seems to block the repair of damaged nerve cells.   More...
20 Aug 2014
Image: In mice whose brain tumor cells (in green) could not make galectin-1, the body’s immune system was able to recognize and attack the cells, causing them to die. In this microscope image, the orange areas show where tumor cells had died in just the first three days after the tumor was implanted in the brain. Six days later, the tumor had been eradicated (Photo courtesy of the University of Michigan).

Surface Protein Protects Brain Tumor Cells from Immune Attack

Malignant glioma brain tumor cells suppress the natural killer cell immune response by over expressing the surface protein galectin-1, and suppression of this protein renders the tumor cells susceptible to destruction by the immune system.   More...
19 Aug 2014
Image: Extension of human axons into host adult rat white matter and gray matter three months after spinal cord injury and transplantation of human induced pluripotent stem cell-derived neurons. Green fluorescent protein identifies human graft-derived axons, myelin (red) indicates host rat spinal cord white matter and blue marks host rat gray matter (Photo courtesy of UCSD – University of California, San Diego School of Medicine).

Grafted Human Stem Cells Experience Drastic Growth in Spinal Cords of Rats

Scientists have reported that neurons derived from human induced pluripotent stem cells and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals’ central nervous system.  More...
18 Aug 2014
Image: Using CRISPR to silence the E6 gene in Human Papilloma Virus, researchers were able to restart the cervical carcinoma cell\'s natural self-destruct mechanisms, including the gene p53. Similar results were obtained against the HPV-E7 gene, turning on the carcinoma\'s Rb gene (Photo courtesy of Duke University).

Gene Therapy Reactivates Cell Death Pathways in Cervical Cancer Cells

A team of molecular virologists has presented evidence demonstrating the possibility of developing anticancer therapies based on viral vectors that transfect carcinoma cells with RNA-protein complexes capable of reactivating genes in the cancer cells that cause cell cycle arrest and eventual cell death.  More...
18 Aug 2014

Evolutionary Changes Reproduced in the Lab by Manipulating Embryonic Development of Mice

Researchers have been able experimentally to reproduce in mice morphologic alterations that have taken millions of years to occur.  More...
18 Aug 2014
Image: Molecular tags of DNA damage are highlighted in green in blood-forming stem cells (Photo courtesy of UCSF – University of California, San Francicsco).

DNA Replication Difficulty May Be Key to Immune System Aging

People over 60 are not donor candidates for bone marrow transplantation; the immune system ages and weakens with time, making the elderly predisposed to life-threatening infection and other disorders. US researchers have now have found a reason.  More...
13 Aug 2014

Imaging, Genetic Testing Reveal that Tyrolean Iceman had Genetic Predisposition for Atherosclerosis

Although prevalence and types of risk factors for atherosclerosis have varied over time from ancient times to modern society, genetic predisposition/risk for the disorder now appears to be very similar to that in ancient times, according to new imaging and genetic findings gleaned from a 300-year-old glacier mummy.  More...
13 Aug 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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