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Genomics/Proteomics

Image: The green-labeled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red (Photo courtesy of Adriana Sánchez-Danés, Université Libre de Bruxelles).

Stem Cells Not Progenitors Can Trigger Skin Cancer Growth

Cancer researchers have discovered that stem cells can initiate development of malignant skin tumors, while progenitor cells are limited to triggering only benign growths. More...
21 Jul 2016
Image: A normal muscle (left) is compared to a muscle lacking beta1-integrin (right) (Photo courtesy of Chen-Ming Fan, Michelle Rozo / Carnegie Institution for Science).

Age-Related Lack of Attachment Proteins Diminishes Regenerative Ability of Muscle Tissue

The cellular attachment proteins fibronectin and beta1-integrin have been linked to age-related changes that limit the ability of muscle tissue to regenerate and in the reduced maintenance of muscle stem cells. More...
20 Jul 2016
Image: A crystal structure model of the surface of the AAV-2 serotype of adeno-associated virus (Photo courtesy of Wikimedia Commons).

Alpha-1-Antitrypsin Gene Replacement Therapy Cures Emphysema in Mouse Model

A virus-like vector loaded with the gene for production of the enzyme alpha-1-antitrypsin (AAT) successfully established production of the protein in the lungs of mice serving as a model for human emphysema. More...
19 Jul 2016
Image: Three microfluidic devices filled with food color dyes. The device, about the size of a credit card, is designed for the 3D growth of breast, lung, and other types of cancer cells while being exposed to an electric field (Photo courtesy of the Massachusetts Institute of Technology).

Novel 3D Growth Chamber Designed for Investigating Effects of Electric Fields on Cancer

A team of bioengineers designed and manufactured a novel microfluidic device for use in studying the effects of an electric field on the growth and spread of cancer cells. More...
19 Jul 2016
Image: A photomicrograph of a human neuron in culture (Photo courtesy of Shelley Halpain, University of California, San Diego).

Exosome-Derived Biomarker Predicts Likelihood of Developing Alzheimer's Disease

Neurological disease researchers have developed a method for using a biomarker in the blood to predict the likelihood of mild cognitive impairment (MCI) progressing into full-blown Alzheimer's disease (AD). More...
18 Jul 2016
Image: A silver impregnation histopathologic photomicrograph of neurite plaques in the cerebral cortex of a person with Alzheimer\'s disease (Photo courtesy of Wikimedia Commons).

Alzheimer's Disease Mouse Model Links Beta-Amyloid Deposits to Tau Protein Hyperphosphorylation

Neurodegenerative disease researchers have created a genetically engineered mouse model of Alzheimer's disease that is expected to facilitate the study of the molecular mechanisms that underlie the disorder. More...
14 Jul 2016
Image: Pancreatic tumors are surrounded by a protective \"nest\" made of fibrotic scar tissue and the cells that manufacture it (red). A new study in mice demonstrates that disrupting this fibrous tissue makes immune therapy and chemotherapy more effective in attacking tumors of the pancreas (Photo courtesy of the DeNardo Laboratory, Washington University School of Medicine).

Blocking Formation of Scar Tissue Increases Susceptibility of Pancreatic Cancer to Immunotherapy

Cancer researchers have shown that treatment with a focal adhesion kinase (FAK) inhibitor rendered pancreatic cancer tumors susceptible to immunotherapy in a mouse model of the disease. More...
13 Jul 2016


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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