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Genomics/Proteomics

Image: An adult cardiomyocyte has re-entered the cell cycle after expression of miR302-367 (Photo courtesy of the laboratory of Dr. Edward Morrisey, University of Pennsylvania).

Certain MicroRNAs Stimulate Regeneration of Adult Heart Tissue

Cardiac disease researchers working with a mouse model have discovered that by inducing a subset of microRNAs that are active during development but silenced in the adult they could cause damaged adult heart tissue to regenerate.  More...
31 Mar 2015
Image: Many molecular biology studies begin with purified DNA and RNA extracted from complex environments such as the human gut (Photo courtesy of Los Alamos [US] National Laboratory).

New Metagenomics Analysis Tool Reduces False Discovery Rates

Genomic researchers recently described a novel new tool for analyzing the complex data generated during DNA screens of mixed populations of organisms such as the human gut microbiome.  More...
30 Mar 2015
Image: An Austrian Research Center of Industrial Biotechnology researcher is shown working with a laboratory scale continuous antibody purification reactor (Photo courtesy of the Austrian Research Center of Industrial Biotechnology).

Continuous Purification Technique Should Significantly Reduce Antibody Production Costs

An Austrian biotechnology firm has developed a method for the continuous purification of recombinant antibodies from cultures of clarified Chinese hamster ovary cells that promises to significantly reduce the production costs of these important therapeutic and research materials.  More...
29 Mar 2015
Image: The photo shows a mouse pancreatic islet as seen by light microscopy. Beta cells can be recognized by the green insulin staining. Glucagon is labeled in red and the nuclei in blue (Photo courtesy of Wikimedia Commons).

Regenerative Potential Is a Trait of Mature Tissues, Not an Innate Feature of Newly Born Cells

Diabetes researchers have found that the ability of insulin-producing beta cells to replicate and respond to elevated glucose concentrations is absent in very young animals and does not appear until after weaning.  More...
25 Mar 2015
Image: Comparing sections of cortex from a control mouse (left) to a mouse with a presenilin-1 mutation (right). The dashed line indicates the surface of the brain. Presenilin-1 mutations decrease gamma-secretase activity and cause features of neurodegeneration, including shrinkage of the cortex, as shown above (Photo courtesy of Dr. Raymond Kelleher and Dr. Jie Shen, Harvard Medical School).

Presenilin Gene Mutation Linked to Familial form of Alzheimer's Disease

Results obtained in studies using a genetically engineered mouse model of hereditary Alzheimer's disease pointed to the importance of reduced gamma-secretase activity caused by a mutation in the presenilin gene.  More...
24 Mar 2015

The Captureseq Technique Is More Accurate for Low Expressing Genes and Long Non-Coding RNAs

The powerful new CaptureSeq technique for gene analysis was shown to be superior for detecting and quantifying genes with low expression while showing little technical variation and accurately measured differential expression of long non-coding RNAs.  More...
24 Mar 2015
Image: The Mseek technique uses enzymes to purify mitochondrial DNA by deleting the nuclear DNA, leaving behind the pure mitochondrial DNA to be sequenced (Photo courtesy of the Middle East Molecular Biology Society).

New Tool Facilitates Study of Mitochondrial DNA Variation

A new tool has been developed that enables researchers to study mitochondrial heteroplasmy and which will aid them in achieving better understanding of its impact on health and disease.  More...
17 Mar 2015


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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