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12 Nov 2016 - 16 Nov 2016
16 Nov 2016 - 19 Nov 2016


Image: Molecular model of the enzyme encoded by the KAT2A gene (Photo courtesy of Wikimedia Commons).

CRISPR/Cas9 Identifies Potential Drug Target in Acute Myeloid Leukemia

The CRISPR/Cas9 genome editing technique was modified to identify genes critical for the survival and growth of acute myeloid leukemia (AML) cancer cells. More...
27 Oct 2016
Image: Photomicrographs show that placebo-treated cells (left) have far more lipid (red) production compared to ND-646 treated cells (right) (Photo courtesy of the Salk Institute).

Experimental Drug Shrinks Lung Tumors by Blocking Fatty Acid Synthesis

An experimental drug that blocks the activity of the enzyme that regulates de novo fatty acid synthesis caused a dramatic reduction in the size of tumors in animal models of non-small-cell lung cancer (NSCLC). More...
27 Oct 2016
Image: Tumor growth in the xenograft bladder cancer model was monitored using a bioluminescence imaging system. Forty-five days after inoculation, metastatic tumors were detected in the lungs, liver and bone (Photo courtesy of Scientific Reports).

Flufenamic Acid Slows Spread of Bladder Cancer in Mouse Model

The enzyme aldo-keto reductase 1C1, which could be suppressed by the anti-cold drug flufenamic acid, was found to be highly active in metastatic human bladder cancer and represents a potent molecular target for treating the disease. More...
26 Oct 2016
Image: Invasive adenocarcinoma (the most common type of colorectal cancer). The cancerous cells are seen in the center and at the bottom right of the image (blue). Near normal colon-lining cells are seen at the top right of the image (Photo courtesy of Wikimedia Commons).

Active SPARCL1 Slows Growth and Spread of Colorectal Cancer

Cancer researchers have found that the protein SPARCL1 (secreted protein acidic and rich in cysteine like-1) stabilizes mature blood vessels in healthy intestinal tissue, thus preventing the formation of new blood vessels and inhibiting the growth and spread of colorectal cancer. More...
26 Oct 2016
Image: Diagram shows how the neuropeptide Prokineticin-2 (PK2) is rapidly induced during early stages of neurotoxic stress and secreted into extracellular spaces. PK2 is thought to act as a protective mechanism that helps neurons cope with Parkinson’s disease (Photo courtesy of Dr. Anumantha Kanthasamy, Iowa State University).

Protein Helps Neurons Maintain Dopamine Production in Models of Parkinson's Disease

A team of neurodegenerative disease researchers has identified a protein that seems to help neurons in the brain maintain dopamine production. More...
20 Oct 2016
Image: Neutralizing antibodies that bind to specific antigens on the flu virus may aid in the development of a universal influenza vaccine (Photo courtesy of Dr. Matthew Miller, McMaster University).

Mechanism Described for Cytotoxicity Regulation against Influenza A

A new discovery that revealed how neutralizing antibodies bind to specific antigens on the flu virus may aid in the development of a universal influenza vaccine. More...
20 Oct 2016
Image: Digitally colorized transmission electron micrograph (TEM) of Zika virus. Virus particles, colored red, are 40 nanometers in diameter, with an outer envelope, and an inner dense core (Photo courtesy of the CDC).

Post-Infection Zika Virus Shed in Saliva and Semen

Results of a study of the mechanism of Zika virus infection in two primate models demonstrated that the virus spread rapidly into the nervous system of healthy animals and that shedding of the virus in saliva and semen underscored possible concern for additional neurological complications and non-mosquito-mediated transmission in humans. More...
19 Oct 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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