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Genomics/Proteomics

Image: Pluristem technicians produce PLacental eXpanded (PLX) cells in the company\'s state-of-the-art facility (Photo courtesy of Pluristem Therapeutics).

Placental Cells Secrete Factors That Protect Nerves from Ischemic Damage

Cells derived from placenta have been found to protect PC12 cells—rat-derived cells that behave similarly to and are used as stand-ins to study human nerve cells—in a culture-based ischemic stroke model.  More...
25 Jan 2015
Image: Researchers have developed a three-dimensional culture system to grow organoids from mouse and human pancreatic tissue. The technology promises to change the way pancreatic cancer research is done, offering a path to personalized treatment approaches (Photo courtesy of Cold Springs Harbor Laboratory).

Organoids Aid Discovery of New Approaches for Treating Pancreatic Cancer

Cancer researchers have established a method for culturing organoids from normal and cancerous mouse and human pancreatic tissues that is expected to boost development of personalized treatment approaches for this deadly disease.  More...
25 Jan 2015
Image: The bone marrow of mice with normal ether lipid production (top) contains more white blood cells than are found in the bone marrow of mice with ether lipid deficiency (bottom) (Photo courtesy of Washington University School of Medicine).

Inactivating Fatty Acid Synthase Reduces Inflammation by Interfering with Neutrophil Membrane Function

The enzyme fatty acid synthase was shown to regulate inflammation by sustaining neutrophil viability through modulation of membrane phospholipid composition.  More...
19 Jan 2015
Image: A new finding goes against dogma, showing for the first time that the building blocks of a protein, called amino acids, can be assembled by another protein, and without genetic instructions. The Rqc2 protein (yellow) binds tRNAs (dark blue, teal), which add amino acids (bright spot in middle) to a partially made protein (green). The complex binds the ribosome (white) (Photo courtesy of Janet Iwasa, PhD, University of Utah).

Challenging Classic Science Principles, New Research Finds New Role for Proteins

A new study revealed for the first time that the essential components of a protein, called amino acids, can be assembled without blueprints—DNA and an intermediate template called messenger RNA. Researchers have observed an instance in which another protein specifies which amino acids are added.   More...
14 Jan 2015
Image: Molecular structure of phosphatidylinositol (Photo courtesy of Wikimedia Commons).

Cancer Cells with p53 Mutations Have Phosphatidylinositol Signaling Molecules with Shortened Lipid Acyl Chains

A recent study showed that cancer cells with mutations in the p53 gene were distinguished by reduced-length fatty acid moieties in their cell membranes.  More...
13 Jan 2015

Enzyme Found to Trigger the Immune System, Providing Clues on Alzheimer’s-Related Protein

New findings with a specific enzyme could provide more clues on presenilin functions, in addition to providing a better determination into how the immune system is controlled.  More...
13 Jan 2015
Image: Micrograph showing human chromosomes (grey) capped by telomeres (white) (Photo courtesy of the US Department of Energy Human Genome Program).

Experimental Cancer Drug Disrupts Telomerase Function

Cancer researchers have published a detailed study of the potential chemotherapeutic drug 6-thio-2'-deoxyguanosine, a potent inhibitor of the enzyme telomerase.  More...
12 Jan 2015


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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