We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




MicroRNAs Are Regulators and Biomarkers of Bone Cancer Metastasis

By LabMedica International staff writers
Posted on 30 Oct 2013
Print article
Image: Researchers at Princeton University have found that microRNAs may serve as both therapeutic targets and predictors of metastasis. In this image, breast cancer cells (right) spread toward the hindlimb bone (left), using the host's own osteoclasts to continue their advance (Photo courtesy of Dr. Yibin Kang, Princeton University).
Image: Researchers at Princeton University have found that microRNAs may serve as both therapeutic targets and predictors of metastasis. In this image, breast cancer cells (right) spread toward the hindlimb bone (left), using the host's own osteoclasts to continue their advance (Photo courtesy of Dr. Yibin Kang, Princeton University).
Different groups of microRNAs (miRNAs) have been found to either inhibit or promote metastasis of cancer in the bone, which occurs in about 70% of patients with late-stage cancer.

Investigators at Princeton University (Princeton, NJ, USA) reported in the October 14, 2013, edition of the journal Cancer Cell that miR-141 and miR-219 inhibited metastasis by targeting osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibited osteoclast activity and reduced osteolytic bone metastasis.

In contrast, serum levels of sICAM1 (soluble intracellular adhesion molecule) and two osteoclast miRNAs, miR-16 and miR-378, which were elevated in osteoclast differentiation, correlated with increased bone metastasis in mouse models.

"The tumor uses the osteoclasts as forced labor," said senior author Dr. Yibin Kang, professor of molecular biology at Princeton University. "We ultimately hope to extend mice experimentation to clinical trials. In the end, we want to help the patients."

The authors suggested that the findings published in the Cancer Cell paper establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis.

Related Links:

Princeton University


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Xylazine Immunoassay Test
Xylazine ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The cobas Malaria test is the first FDA-approved molecular test to screen U.S. blood donors for malaria (Photo courtesy of Roche)

First FDA-Approved Molecular Test to Screen Blood Donors for Malaria Could Improve Patient Safety

Malaria, a serious illness that often leads to death, is spread by a specific mosquito species that infect humans with a parasite. Other transmission modes include blood transfusions, organ transplants,... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The medical office procedure detects the key biomarker in Parkinson’s and related neurodegenerative diseases (Photo courtesy of BIDMC)

Simple Skin Biopsy Test Detects Parkinson’s and Related Neurodegenerative Diseases

Parkinson's disease and a group of related neurodegenerative disorders known as synucleinopathies impact millions globally. These conditions, including Parkinson’s disease (PD), dementia with Lewy bodies... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.